ROLE OF RAGE AS AN AMPHOTERIN RECEPTOR: FROM DEVELOPMENT TO DISEASE

Henri Huttunen

ISBN 10: 3838323475 / ISBN 13: 9783838323473

Editore: Lap Lambert Acad. Publ., 2009

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64 pages. 8.70x5.94x0.31 inches. In Stock. Codice articolo __3838323475

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Titolo: ROLE OF RAGE AS AN AMPHOTERIN RECEPTOR: FROM...

Casa editrice: Lap Lambert Acad. Publ.

Data di pubblicazione: 2009

Legatura: Paperback

Condizione: Brand New

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Riassunto:

Cell migration plays a vital role in many physiological processes, such as embryonic development and immunological defense, but also in pathological processes, such as tumor cell invasion. Amphoterin, also known as High-Mobility Group-Box protein 1 (HMGB1), is highly expressed in immature and malignant cells. Although it lacks a classical secretion signal, amphoterin is released from cells to regulate neurite outgrowth, cell migration and differentiation. Many extracellular functions of amphoterin are mediated by one of its cell surface receptors Receptor for Advanced Glycation End products (RAGE), a multiligand receptor belonging to the immunoglobulin superfamily. This thesis concentrates on identifying molecular mechanisms through which RAGE mediates effects of extracellular amphoterin on cells. The results suggest that amphoterin and RAGE serve as a ligand-receptor pair having important roles in the regulation of neuronal process growth, survival and differentiation, and in the regulation of tumor cell invasiveness.

L'autore:

Henri Huttunen earned his Ph.D. in biochemistry from University of Helsinki. His research focuses in molecular mechanisms underlying the generation and loss of connectivity of neurons in the brain. He has studied molecules regulating cell migration in the developing brain and more recently mechanisms of neurodegeneration in Alzheimer's disease.