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Sensory Nerves

Domenico Spina

Editore: Springer-Verlag Gmbh Aug 2009, 2009
ISBN 10: 3540790896 / ISBN 13: 9783540790891
Nuovi / Buch / Quantità: 1
Da Rhein-Team Lörrach Ivano Narducci e.K. (Lörrach, Germania)
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Titolo: Sensory Nerves

Casa editrice: Springer-Verlag Gmbh Aug 2009

Data di pubblicazione: 2009

Legatura: Buch

Condizione libro: Neu

Descrizione:

Neuware - Theintentionofthisbookistoprovideacomprehensiveandcontemporaryreview ofthebiologyofsensorynerves. InkeepingwiththethemeoftheHandbookof Experimental Pharmacology series, emphasis will be placed on the actions of drugs,transmittersandautacoidsthatinitiateorinhibitsensorynerveactivation (through actionsonionchannelsandreceptorsattheirperipheralterminals)or modulate the release or actions of the transmitters released from the central terminalsofsensorynerves. Onthebasisofextensivesupportiveevidenceinthe literature, it is our view that many diseases are characterized by alterations in sensorynervefunction(e. g. pain,cardiovasculardiseaseandmigraine). Itisour beliefthatthisbookwillbeunique,asitwillcomprehensivelycovertheroleof sensory nerves across many therapeutic areas. To address directly one of the editorialboardqueries,thisisnotintendedtobeabookaboutthepharmacology ofpain. Thatsaid,tomostpharmacologists,painisthemostobviousindicationfor aroleorsensorynervesindisease. Webelievethatthelessonslearntfromthestudy ofneuropathicpainwillbeinvaluableforresearchersintheothertherapeuticareas covered inthisvolume. Sincemostinterest hasfocusedontheroleofsensory nervesinneuropathicpain,wehaveaddedanumberofchaptersdevotedtothis subject. Thebookisorganizedinthreeparts,coveringthetypesandrolesofsensory nervesinsomaticandvisceraldisorders(PartI),speci ctargetsonsensorynerves relevanttopainandvisceraldisorders(PartII)andadescriptionofcurrentand futuretherapeuticstrategiesfortargetingsensorynerves(PartIII). The rsttwochaptersinPartIaredevotedtodescribingtheclinicalfeaturesof neuropathicpainandvisceralpain. Ourintentionisfortheauthorstoprovidea clinicalviewpointonthefeaturesoftheseconditionsandtheadvantages/disadv- tagesofcurrenttreatmentmodalities. Thenext vechaptersinPartIfocusonthe roleofsensorynervesinotherpathologicalconditions. Severalcommonthemes willemergeinthispart,includingthemodeofsensorynerveactivationinvarious tissues and organs, the alterations in sensory nerve excitability associated with disease,andtheimportanceofin ammationandin ammatorymediatorsininiti- ingalteredsensorynervefunctionindisease. v vi Preface Whilstthe rstpartfocusesontheclinicaland/orsystemsphysiology,PartIIhas itsfocusatthecellandmolecularlevel. Thisparthighlightsthecurrentundersta- ingofproteins/ionchannels/mediatorsthathavecreatedthemostintenserecent interestintheareaofsensorynervebiology. Together,thesechapterswillgivethe reader important knowledge about how sensory nerve function can be altered pharmacologically. Thelastchapterinthispartdescribestheprocessesthatgive risetoalteredneuralre exesatthecentrallevel. Themechanismsdescribedin thesechaptersreinforcetheroleofproteins/mediatorshighlightedinthepreceding chapters. Theroleofthesecellular,molecularandphysiologicalprocessesinthe diseasesdiscussedinPart1areemphasized. TheaimofPartIIIistohighlightpotentialdrugtargetsthatmightaltersensory nervefunction. Mostoftheworkhasbeendevotedtothetreatmentofneuropathic painandsothispartheavilyemphasizesthissubject. However,aswillbeapparent fromPartI,manyofthesetargetscouldbeutilizedinothertherapeuticareasthat implicatesensorynervesintheirpathophysiologicalprocesses. Thefocusofthe chaptersisonopioidsandmodulatorsofionchannelsandthenthe nalchapteris devotedtofuturetreatmentstrategiesforneuropathicpain. Finally,wewouldliketothankallthecontributors,includingco-authors,who agreedtowritechaptersforthisbookandthepublishers,especiallySusanneDathe, fortheirpatienceandassistance. Baltimore B. J. Canning London D. Spina Contents PartI RoleofSensoryNervesinDisease NeuropathicPain:AClinicalPerspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 RalfBaron VisceralPain:TheNeurophysiologicalMechanism. . . . . . . . . . . . . . . . . . . . . . . . . . 31 JyotiN. Sengupta Migraine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75 SilviaBenemei,PaolaNicol. Codice inventario libreria 9783540790891

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Riassunto: The intention of this book is to provide a comprehensive and contemporary review of the biology of sensory nerves. In keeping with the theme of the Handbook series, an emphasis will be placed on the actions of drugs, transmitters and autacoids that initiate or inhibit sensory nerve activation (through actions on ion channels and receptors at their peripheral terminals) or modulate the release or actions of the transmitters released from the central terminals of sensory nerves. Based on extensive supportive evidence in the literature, it is our view that many diseases are characterised by alterations in sensory nerve function (eg pain, cardiovascular disease, and migraine). It is our belief that this book will be unique, as it will comprehensively cover the role of sensory nerves across many therapeutic areas.

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Libreria: Rhein-Team Lörrach Ivano Narducci e.K.
Indirizzo: Lörrach, Germania

Libreria AbeBooks dal: 11 gennaio 2012
Valutazione libreria: 5 stelle

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