Stem Cells and Cancer

Sadhan Majumder

ISBN 10: 0387896104 / ISBN 13: 9780387896106

Editore: Springer New York, Springer US Jun 2009, 2009

Riguardo questo articolo

Neuware -Cancer is a primary cause of human mortality worldwide. Despite decades of basic and clinical research, the outcome for most cancer patients is still dismal. Some stumbling blocks to developing effective therapy include the heterogeneity of cancer tissues, the lack of knowledge about the critical molecular mechanisms in cancer tissues (which are typically aberrant compared with mechanisms in normal tissue), and the lack of good mechanism-based therapeutic approaches. The recent findings that most cancers contain a small fraction of self-renewing, differentiation-blocked stem cell-like cells (cancer stem cells) and that it is these cells¿and not the major bulk of the tissue¿that are the root cause for cancer initiation and metastasis have also highlighted the need to change our approach to cancer therapy.The objectives of this book, therefore, would be to impart up-to-date information about the role of stem cells in the development of normal and cancerous tissue, the mechanisms that differentiate normal from cancerous functions, and the use of these findings in developing mechanism-based therapies.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 312 pp. Englisch.

Codice articolo 9780387896106

Dati bibliografici

• Titolo: Stem Cells and Cancer
• Editore: Springer New York, Springer US Jun 2009
• Data di pubblicazione: 2009
• Lingua: Inglese
• ISBN 10: 0387896104
• ISBN 13: 9780387896106
• Rilegatura: Buch
• Condizione: Neu
• Dimensioni: 241 L x 160 A x 24 P (millimetri) 241 millimetri di larghezza per 160 millimetri di altezza per 24 millimetri di profondità
• Peso: 692 grammi

Descrizione articolo

Riassunto

Cancer is a primary cause of human mortality worldwide. Despite decades of basic and clinical research, the outcome for most cancer patients is still dismal. Some stumbling blocks to developing effective therapy include the heterogeneity of cancer tissues, the lack of knowledge about the critical molecular mechanisms in cancer tissues (which are typically aberrant compared with mechanisms in normal tissue), and the lack of good mechanism-based therapeutic approaches. The recent findings that most cancers contain a small fraction of self-renewing, differentiation-blocked stem cell-like cells (cancer stem cells) and that it is these cells―and not the major bulk of the tissue―that are the root cause for cancer initiation and metastasis have also highlighted the need to change our approach to cancer therapy.

The objectives of this book, therefore, would be to impart up-to-date information about the role of stem cells in the development of normal and cancerous tissue, the mechanisms that differentiate normal from cancerous functions, and the use of these findings in developing mechanism-based therapies.

Dalla quarta di copertina

Cancer is a major cause of human morbidity and mortality worldwide. Despite decades of basic and clinical research, the outcome for many cancer patients is still dismal. Although the existence of "stem-like" cells in cancer was hypothesized more than 150 years ago, recent discoveries have the potential to revolutionize cancer therapy. In particular, we now know that many cancers contain a fraction of self-renewing, drug- and radiation-resistant cells (cancer stem cells or cancer-initiating cells) and it is these cells―and not the major bulk of the tissue―that are the root cause for cancer initiation, relapse and metastasis. In a single volume, Stem Cells and Cancer offers up-to-date information about the role of stem cells in the development of normal and cancerous tissue, the mechanisms that differentiate normal from cancerous functions, and the use of these findings in developing mechanism-based therapies across all major types of cancer. It provides timely, cutting-edge information about cancer stem cells from the perspectives of both the basic and clinical sciences.