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9780123868824: Handbook of Pharmacogenomics and Stratified Medicine
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Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by  pharmacogenomics and stratified medicine details.

Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development.



  • Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise
  • Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics,  pharmacokinetics and pharmacodynamics
  • Covers newer technologies– next generation sequencing, proteomics, metabolomics
  • Provides information on animal models, lymphoblastoid cell lines, stem cells
  • Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues
  • Includes chapters on the global implications of pharmacogenomics

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Recensione:

"...a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time." --Anticancer Research, January 2015

"This is an extremely useful resource for clinicians, scientists, or any individuals interested in an excellent review of the rapidly advancing field of pharmacogenomics and its increasing relevance for clinical practice. - Rating: 5 Stars" --Doody's.com, Oct 2014

L'autore:
Dr. Sandosh Padmanabhan is a Professor and Physician at the Institute of Cardiovascular and Medical Sciences, University of Glasgow. Dr. Padmanabhan completed his MBBS and MD at JIPMER, Pondicherry, India and was awarded the Gold Medal for MD General Medicine in 1995. His PhD thesis (1999-2003) on G-protein signaling in hypertension was awarded the Bellahouston Medal by the University of Glasgow in 2004, and he received the Austin Doyle Award from the International Society of Hypertension in 2004. Dr. Padmanabhan’s pharmacogenetic genome-wide linkage study led to a BHF Intermediate Fellowship (2006-2009), and he also led a genome wide association analysis of hypertension between 2008 and 2010, resulting in the discovery of a new gene and pathway for hypertension. Dr. Padmanabhan was a visiting fellow to the Broad Institute of Harvard and MIT (2010-2012). Currently, he is a Fellow of the Royal College of Physicians, the British Hypertension Society, and the American Heart Association. His active research areas span the genetics of cardiovascular traits, pharmacogenomics and stratified medicine, and hypertension epidemiology.

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  • EditoreAcademic Pr
  • Data di pubblicazione2014
  • ISBN 10 0123868823
  • ISBN 13 9780123868824
  • RilegaturaCopertina rigida
  • Numero edizione1
  • Numero di pagine1093
  • RedattorePadmanabhan Sandosh

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9780128100523: Handbook of Pharmacogenomics and Stratified Medicine

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ISBN 10:  ISBN 13:  9780128100523
Casa editrice: Academic Press, 2017
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Sandosh Padmanabhan
ISBN 10: 0123868823 ISBN 13: 9780123868824
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Descrizione libro Hardcover. Condizione: New. Codice articolo 6666-ELS-9780123868824

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Editore: Lala Maurizio (2014)
ISBN 10: 0123868823 ISBN 13: 9780123868824
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Descrizione libro Condizione: new. Questo è un articolo print on demand. Codice articolo 8c4eb05456fd8d6a4935a7c8618cb42e

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Padmanabhan, Sandosh (Editor)
Editore: Academic Pr (2014)
ISBN 10: 0123868823 ISBN 13: 9780123868824
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Revaluation Books
(Exeter, Regno Unito)
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Descrizione libro Hardcover. Condizione: Brand New. 1st edition. 1093 pages. 10.75x8.50x2.25 inches. In Stock. Codice articolo __0123868823

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