Mechanisms of Drug Resistance in Epilepsy: Lessons from Oncology - Rilegato

Novartis Foundation

Rilegato

ISBN 10: 047084146X ISBN 13: 9780470841464

Casa editrice: John Wiley & Sons Inc, 2002

Riassunto

The object of this book is to gather together workers in the fields of epilepsy, those concerned with the basic science of resistance and the blood-brain barrier, and those with clinical experience of drug resistance in cancer, with a view to stimulating further work on drug resistance in epilepsy. Whilst resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken, with some success, resistance in epilepsy has only just begun to be addressed.

Su questo libro

L'autore:

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Dalla quarta di copertina:

Drug resistance in epilepsy is an important clinical problem. About 20% of patients diagnosed as having epilepsy fail to respond to prescribed antiepileptic drugs and continue to have seizures. But despite the size of the problem, remarkably little attention has been paid to the biological basis of refractory epilepsy. Recent work has shown that brain tissue from some patients with epilepsy shows increased expression of a protein that mediates drug resistance in cancer, P glycoprotein. But while resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken with some success, resistance in epilepsy has only just begun to be addressed. This novel book brings together, for the first time, epilepsy researchers and oncologists, with a view to stimulating further work on drug resistance in epilepsy. Successfully bridging the two fields, the stimulating discussions contained in this book should be of great interest to those working on cancer resistance and refractory epilepsy alike.

Su questa edizione

• Editore: John Wiley & Sons Inc
• Data di pubblicazione: 2002
• ISBN 10: 047084146X
• ISBN 13: 9780470841464
• Rilegatura: Copertina rigida
• Numero di pagine: 254