Chemistry and Biology of Synthetic Retinoids - Rilegato

Dawson, Marcia I.; Okamura, William H.

Rilegato

ISBN 10: 0849347971 ISBN 13: 9780849347979

Casa editrice: CRC Press, 1990

Riassunto

The purpose of this book is to present an overview of advances in both retinal and retinoic acid synthetic chemistry and biology. Chapters are written by research workers who are active in these fields. Emphasis is placed on structure-activity relationships. It includes topics of cell differentiation, maintenance of cell morphology, and vision. This reference contains a special section on assays which were developed to measure retinoid activity. This book is ideal for those interested in the fields of photobiology, organic chemistry, biological chemistry, and nutrition.

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Contenuti:

The Bioorganic Chemistry of Vision (Robert R. Rando). The Molecular Basis of the Visual Cycle (C.D.B. Bridges). The Binding Site of Opsin Based on Analog Studies with Isomeric, Fluorinated, Alkylated, and Other Modified Retinals (Robert S.H. Liu and Alfred E. Asato.). Synthesis and Application of Retinoids and Related Compounds to Vision Research and Cancer Studies (Mayayoshi Ito). Molecular Mechanism for the Function of Bacteriorhodopsin and Visual Pigments: Studies with Model Compounds and Artificial Pigments (Mordechai Sheves and Michael Ottolenghi). Analog Pigments of Rhodopsin and Bacteriorhodopsin; Retinal-Binding Site and Role of the Chromophore in the Functionality of the Pigments (Rosalie K. Crouch). Visual Pigment and Bacteriorhodopsin Analogs (Valeria Balogh-Nair and Koji Nakanishi). Acetylenic Intermediates in Retinoid Synthesis (Henning Hopfand Norbert Krause). Synthesis and Studies of 12-s-cis Conformationally Locked Retinoids (Angel R. de Lera; Roshantha A.S. Chandraratna; and William H. Okamura.). Is Retinoic Acid a Physiologically Significant Promoter of Differentiation? (Joseph L. Napoli). Inhibition of Melanoma Growth by Retinoids: Structure-Activity Relationships (Reuben Lotan and Dafna Lotan). Structure-Activity Relationships of a New Series of Synthetic Retinoids (Retinobenzoic Acids) (Koichi Shudo and Hiroyuki Kagechika). Regulation of Squamous Differentiation in Tracheobronchial Epithelial Cells by Synthetic Retinoids (Anton M. Jetten). Structure-Biological Activity Relationships of New Synthetic Retinoids on Epithelial Differentiation of Cultured Hamster Trachea (Leonard J. Schiff; William H. Okamura; Marcia I. Dawson; and Peter D. Hobbs). Cellular Retinoic Acid-Binding Protein and the Action of Retinoic Acid (Brahma P. Sani). The Inhibitory Effects of Retinoids on the Induction of Ornithine Decarboxylase and the Promotion of Tumors in Mouse Epidermis (Marcia I. Dawson; Wan-Ru Chao; Peter D. Hobbs; and Thierry Delair). Role of Retinoids in Prevention of Cutaneous Cancer (Helen L. Gensler and Frank L. Meyskens, Jr.). Epidermal Responses to Retinoids In Vivo (Michael J. Connor). Retinoid Inhibition of Experimental Carcinogenesis (Richard C. Moon and Rajendra G. Mehta.). Retinoids as Potential Antirheumatic Agents (John W. Coffey; Christa Fiedler-Nagy; Stephen M. Weisman; Thasis G. Woodworth; and Ann F. Welton). Molecular Correlates in Retinoid Pharmacology and Toxicology (Calvin C. Willhite). Carcinogenesis Inhibitory Properties of Retinoids: A QSAR-MTD Analysis (I. Niculescu-Duvaz; Z. Simon; and N. Voiculetz). c. 560 pp., 7x10, 1989, ISBN-0-8493-4797-1.

Features:

Su questa edizione

• Editore: CRC Press
• Data di pubblicazione: 1990
• ISBN 10: 0849347971
• ISBN 13: 9780849347979
• Rilegatura: Copertina rigida
• Numero edizione: 1
• Numero di pagine: 632