Quantum Tunnelling in Enzyme-Catalysed Reactions: Volume 17 - Rilegato

Rilegato

ISBN 10: 0854041222 ISBN 13: 9780854041220

Casa editrice: Royal Society of Chemistry, 2009

Riassunto

In recent years, there has been an explosion in knowledge and research associated with the field of enzyme catalysis and H-tunneling. Rich in its breath and depth, this introduction to modern theories and methods of study is suitable for experienced researchers those new to the subject. Edited by two leading experts, and bringing together the foremost practitioners in the field, this up-to-date account of a rapidly developing field sits at the interface between biology, chemistry and physics. It covers computational, kinetic and structural analysis of tunnelling and the synergy in combining these methods (with a major focus on H-tunneling reactions in enzyme systems). The book starts with a brief overview of proton and electron transfer history by Nobel Laureate, Rudolph A. Marcus. The reader is then guided through chapters covering almost every aspect of reactions in enzyme catalysis ranging from descriptions of the relevant quantum theory and quantum/classical theoretical methodology to the description of experimental results. The theoretical interpretation of these large systems includes both quantum mechanical and statistical mechanical computations, as well as simple more approximate models. Most of the chapters focus on enzymatic catalysis of hydride, proton and H" transfer, an example of the latter being proton coupled electron transfer. There is also a chapter on electron transfer in proteins. This is timely since the theoretical framework developed fifty years ago for treating electron transfers has now been adapted to H-transfers and electron transfers in proteins. Accessible in style, this book is suitable for a wide audience but will be particularly useful to advanced level undergraduates, postgraduates and early postdoctoral workers.

Su questo libro

Recensione:

Quantum tunnelling in enzyme-catalysed reactions

Rudolf Allemann and Nigel Scrutton (Eds.)
RSC Publishing, Cambridge, UK, 2009, 385pp, (HB) ISBN 9780854041220

This book gives an up-to-date account of the field of enzyme catalysis and hydrogen-tunnelling. It covers computational, kinetic and structural analysis of hydrogen transfer and the synergy in combining these methods. The book describes new theoretical frameworks for H-tunnelling reactions and indicates how experimental and computational studies have provided evidence to support these new models for biological catalysis. The book is an excellent primer for those new to the field of biological catalysis of hydrogen-transfer. Early chapters introduce basic concepts and models, which underpin more detailed discussion of theory and experimental approaches, with reference to key case studies.

L'autore:

Nigel S. Scrutton graduated from King's College University of London before obtaining PhD and ScD degrees at the University of Cambridge. He is currently BBSRC Professorial Fellow and Professor of Enzymology at the University of Manchester. He has a longstanding interest in structural and mechanistic enzymology and has made a number of major contributions to the field of H-tunneling in biological systems. He has also been involved in interdisciplinary research programmes addressing the mechanisms of electron and hydrogen transfer in biology. Rudolf K. Allemann obtained a Dipl. Chem from the ETH in Zurich. He then studied for a PhD at Harvard University and the ETH-Zurich where he obtained Dr. sc. Nat. in 1988. He is currently a Research Professor and head of Chemical Biology at Cardiff University. His research interests focus on the physical and chemical basis of enzyme catalysis and structural and synthetic biology. He has also been involved in the de novo design of peptides that catalyze reactions with enzyme-like characteristics. Recently, he has pioneered the development of biophotonic nanoswitches for the control of protein-DNA and protein-protein interactions.

Su questa edizione

• Editore: Royal Society of Chemistry
• Data di pubblicazione: 2009
• ISBN 10: 0854041222
• ISBN 13: 9780854041220
• Rilegatura: Copertina rigida
• Numero di pagine: 385
• Redattore: Allemann Rudolf K., Scrutton Nigel S.