Over the last decade, scientific and engineering interests have been shifting from conventional ion mobility spectrometry (IMS) to field asymmetric waveform ion mobility spectrometry (FAIMS). Differential Ion Mobility Spectrometry: Nonlinear Ion Transport and Fundamentals of FAIMS explores this new analytical technology that separates and characterizes ions by the difference between their mobility in gases at high and low electric fields. It also covers the novel topics of higher-order differential IMS and IMS with alignment of dipole direction.
The book relates the fundamentals of FAIMS and other nonlinear IMS methods to the physics of gas-phase ion transport. It begins with the basics of ion diffusion and mobility in gases, covering the main attributes of conventional IMS that are relevant to all IMS approaches. Building on this foundation, the author reviews diverse high-field transport phenomena that underlie differential IMS. He discusses the conceptual implementation and first-principles optimization of FAIMS as a filtering technique, emphasizing the dependence of FAIMS performance metrics on instrumental parameters and properties of ion species. He also explores ion reactions in FAIMS caused by field heating and the effects of inhomogeneous electric field in curved FAIMS gaps.
Written by an accomplished scientist in the field, this state-of-the-art book supplies the foundation to understand the new technology of nonlinear IMS methods.
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This book is a compendium of achievements in differential ion mobility spectrometry with special respect to nonlinear ion transport.
―Jörg Ingo Baumbach in International Journal for Ion Mobility Spectrometry
... a very well written book ... filled a void in my library ....
―Randy W. Purves, National Research Council of Canada, in Journal of The American Society for Mass Spectrometry, 2010
... this is a very well written book, and the author’s interest
and enthusiasm in the technique comes across in his work. The book has filled a void in my library as a valued reference for FAIMS. I would recommend this book to those currently working with FAIMS technology
and especially to researchers with plans to advance further the technology. I look forward to the release of the second volume.
―Randy W. Purves, Plant Biotechnology Institute, National Research Council of Canada, in the Journal of the American Society for Mass Spectrometry
... an excellent reference on the topics of both linear and nonlinear modes of ion mobility measurements ... The writing style is very personal: you can almost hear the author speak to you as you read the text. ... At the end of the book, you will feel that the story of nonlinear ion mobility measurements is just unfolding and it should have many interesting new applications and discoveries.
―Peter de Boves Harrington, Ohio University, in Journal of the American Chemical Society, 2010, 132
Separation and Characterization of Molecules and Ions Using Gas-Phase Transport
Physical Foundation and Definitions
Characterization of Molecules by Diffusion Measurements
IMS: Ion Dynamics in IMS and Consequent General Features
Relating IMS Data to Molecular Structure
Fundamentals of High-Field Ion Mobility and Diffusion
General Aspects of High-Field Ion Mobility: Standard and Nonstandard Effects
Standard High-Field Effect
Clustering of Gas Molecules on Ions and Standard High-Field Effect
Non-Blanc Phenomena in High-Field Ion Transport
Vibrationally Inelastic Collisions
Rotational Inelasticity and Collisional Alignment of Ions
Dipole Alignment of Ions
Unstable High-Field Mobility of Runaway Ions
Summary and Significance for Differential IMS
Conceptual Implementation of Differential IMS and Separation Properties of FAIMS
Strategy for Optimum Differential Ion Mobility Separations
Limitations on the Differential IMS Paradigm That Shape FAIMS Approach
Trends of FAIMS Separation Parameters
Separations in Heteromolecular Media
Ion Transformations inside FAIMS and Effect on Separation Performance
Separation Performance of FAIMS and Its Control via Instrumental Parameters
Approaches to Simulation of FAIMS Operation
Separation Properties in Homogeneous Electric Field
Ion Focusing in Inhomogeneous Fields and Consequences for FAIMS Performance
Beyond FAIMS: New Concepts in Nonlinear Ion Mobility Spectrometry
Ion Guidance and Trapping at Atmospheric Pressure
Higher-Order Differential (HOD) IMS Methods
Ion Mobility Spectrometry with Alignment of Dipole Direction (IMS-ADD)
Index
References appear at the end of each chapter.
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Spese di spedizione:
EUR 17,48
Da: Regno Unito a: U.S.A.
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