Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.
1 Long known, long ignored – a brief history of cytomegalovirus research
1.1 Beginnings: 1881–1914
1.2 Between the wars: 1914–1930
1.3 From 1930 to 1960
1.4 From 1960 to the present
References
2 Virus-host interaction for defence and transmission
2.1 The virus
2.2 The host
2.2.1 Cell types involved in replication and distribution
2.2.2 The immune system – strengths and weakness
2.2.3 The placenta – a barrier?
2.2.4 Cytomegalovirus – placenta – fetus: a slippery slope between defence and transmission
References
3 Epidemiology – the influence of socioeconomic differences
3.1 Infant mortality as a social mirror
3.2 One effect – many causes
3.2.1 Maternal aetiology
3.2.2 Foetal aetiology
3.2.3 Placental aetiology
3.3 Epidemiology of congenital CMV infection
3.3.1 Congenital CMV and virus strains
References
4 Prospects and obstacles of diagnosis
4.1 Screening for congenital CMV infection
4.1.1 Screening of the mother
4.1.2 Screening of the newborn
4.2 Diagnosis of congenital CMV infection
4.2.1 Prenatal diagnosis
4.2.2 Neonatal diagnosis
References
5 Clinical outcome: acute symptoms and sleeping hazards
Thorsten W. Orlikowsky
5.1 Relevance of connatal CMV infection for the paediatrician and neonatologist
5.2 The tip of the iceberg
5.3 Lucky chance by neonatal immune response
5.4 Features of symptomatic CMV infection
5.5 Timing of infection
5.6 Symptoms of the central nervous system in detail
5.6.1 Microcephaly5.6.2 Ocular defects
5.6.3 Hearing loss
5.6.4 Mental and psychomotor retardation
5.6.5 Seizures
5.7 Unspecific symptoms in detail
5.7.1 Temperature instability
5.7.2 Perfusion and rash
5.7.3 Lung
5.7.4 Liver
5.7.5 Jaundice
5.7.6 Spleen
5.7.7 Platelet system
5.7.8 Anaemia
5.7.9 Gastrointestinal tract
5.8 Asymptomatic infection
5.9 Differential diagnosis
References
6 Prevention and therapy – more than trial and error
6.1 Antivirals
6.1.1 Treatment of pregnant women
6.1.2 Treatment of neonates
6.2 Passive immunisation
6.3 Active immunisation (vaccination)
References
7 How to save money: congenital CMV infection and the economy
Evelyn Walter, Christine Brennig, Vera Schollbauer
7.1 Introduction
7.2 Methodology
7.2.1 Incidence-based approach
7.2.2 Cost calculation
7.2.3 Cost of sequelae
7.3 Cost of illness in Germany
7.3.1 Total societal costs
7.3.2 Sensitivity analysis
7.3.3 Impact through prevention
7.4 Discussion
References
Index
List of contributors
Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.
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Da: Germania a: U.S.A.
Descrizione libro 15 ills., XI, 149 p. Hardcover. Versand aus Deutschland / We dispatch from Germany via Air Mail. Einband bestoßen, daher Mängelexemplar gestempelt, sonst sehr guter Zustand. Imperfect copy due to slightly bumped cover, apart from this in very good condition. Stamped. Stamped. Gestempelt "Mängelexemplar"/ stamped "imperfect copy". Bestoßen. Sprache: Englisch. Codice articolo 2992IB