springer berlin heidelberg mai 2014 (291 risultati)

Taschenbuch. Condizione: Neu. Neuware -Why do things go wrong Why, despite all the planning and care in the world, do things go from bad to worse This book argues that it is because we are like the ants. Just as ants create an anthill without being aware of it, unintended side effects of human activity create all manner of social trends and crises. The book traces the way these trends emerge and the role they play in some of the major issues of our time. One of the greatest challenges today is the complexity of our social and economic systems. Every action has side effects that people often ignore or fail to see. The book examines the ways in which limitations in our thinking and behaviour lead to unintended side effects. It looks at the role played by complex networks of interactions. Finally, it looks at the way side effects of new technologies, especially computers and communication, have created an Information Revolution, the full repercussions of which are yet to be seen. In our race to create new technologies and sustain indefinite economic growth, we are at best dimly aware of the ways in which we are transforming society and threatening our environment.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 284 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book constitutes the thoroughly refereed and revised selected papers from the 9th International Workshop on Agents and Data Mining Interaction, ADMI 2013, held in Saint Paul, MN, USA in May 2013. The 10 papers presented in this volume were carefully selected for inclusion in the book and are organized in topical sections named agent mining and data mining.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 148 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -The research domains of information retrieval and databases have traditionally adopted different approaches to information management. However, in recent years, there has been an increasing cross-fertilization among the two fields and now many research challenges are transversal to them. With this in mind, a winter school was organized in Bressanone, Italy, in February 2013, within the context of the EU-funded research project PROMISE (Participative Research Laboratory for Multimedia and Multilingual Information Systems Evaluation). PROMISE aimed at advancing the experimental evaluation of complex multimedia and multilingual information systems in order to support individuals, commercial entities and communities, who design, develop, employ and improve such complex systems. The overall goal of PROMISE was to deliver a unified environment collecting data, knowledge, tools and methodologies and to help the user community involved in experimental evaluation. This book constitutes the outcome of the PROMISE Winter School 2013 and contains 9 invited lectures from the research domains of information retrieval and databases plus short papers of the best student poster awards. A large variety of topics are covered, including databases, information retrieval, experimental evaluation, metrics and statistics, semantic search, keyword search in databases, semi-structured search, evaluation both in information retrieval and databases, crowdsourcing and social media.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 248 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book constitutes the refereed conference proceedings of the 13th International Symposium, W2GIS 2014, held in Seoul, South Korea, in May 2014. The 12 revised full papers presented were carefully selected from numerous submissions. The program covers a wide range of topics including Communication and Parallel Processing for Geospatial Data, Geo-Social Net, Crowdsourcing, and Trajectory, Geo-Sensor Network, Applications of W2GIS, Indoor GIS.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 208 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Edited in collaboration with FoLLI, the Association of Logic, Language and Information, this book constitutes the refereed proceedings of the 8th International Conference on Logical Aspects of Computational Linguistics (LACL 2014) held in Toulouse, France, in June 2014. On the broadly syntactic side, there are papers on the logical and computational foundations of context free grammars, pregroup grammars, on the Lambek calculus and on formalizations of aspects of minimalism. There is also a paper on Abstract Categorical Grammar, as well as papers on issues at the syntax/semantics interface. On the semantic side, the volume's papers address monotonicity reasoning and the semantics of adverbs in type theory, proof theoretical semantics and predicate and argument invariance.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 208 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book examines the delimited maritime boundaries of Indonesia with its neighbours. It features carefully drawn maps based on the geographical coordinates of the defined maritime boundaries; the reproduction of a complete set of the primary documents with direct relation to the boundaries; and a comprehensive narrative on the geography and the historical development of the archipelagic State. Indonesia has an immense maritime domain that encompasses much of the sea between Australia and the Asian mainland. In addition, Indonesia is itself made up largely of water: in excess of 17,000 islands, Indonesiäs archipelagic and territorial waters together form about three-fifths of the country¿s sovereign territory. This book offers readers clear, accessible information on the maritime boundaries of the world¿s largest archipelagic state.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 284 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book constitutes the proceedings of the 33rd Annual International Conference on the Theory and Applications of Cryptographic Techniques, EUROCRYPT 2014, held in Copenhagen, Denmark, in May 2014. The 38 full papers included in this volume were carefully reviewed and selected from 197 submissions. They deal with public key cryptanalysis, identity-based encryption, key derivation and quantum computing, secret-key analysis and implementations, obfuscation and multi linear maps, authenticated encryption, symmetric encryption, multi-party encryption, side-channel attacks, signatures and public-key encryption, functional encryption, foundations and multi-party computation.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 728 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book contains selected contributions from some of the most renowned researchers in the field of small-scale robotics, based in large part on invited presentations from the workshop ¿The Different Sizes of Small-Scale Robotics: from Nano-, to Millimeter-Sized Robotic Systems and Applications,¿ which was held in conjunction with the conjunction with the International Conference on Robotics and Automation (ICRA 2013), in May 2013 in Karlsruhe, Germany. With many potential applications in areas such as medicine, manufacturing or search and rescue, small-scale robotics represent a new emerging frontier in robotics research. The aim of this book is to provide an insight to ongoing research and future directions in this novel, continuously evolving field, which lies at the intersection of engineering, computer science, material science and biology.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 112 pp. Englisch.

Buch. Condizione: Neu. Neuware -The main goal of this book is to help organizations improve their effort estimates and effort estimation processes by providing a step-by-step methodology that takes them through the creation and validation of models that are based on their own knowledge and experience. Such models, once validated, can then be used to obtain predictions, carry out risk analyses, enhance their estimation processes for new projects and generally advance them as learning organizations.Emilia Mendes presents the Expert-Based Knowledge Engineering of Bayesian Networks (EKEBNs) methodology, which she has used and adapted during the course of several industry collaborations with different companies world-wide over more than 6 years. The book itself consists of two major parts: first, the methodology¿s foundations in knowledge management, effort estimation (with special emphasis on the intricacies of software and Web development) and Bayesian networks are detailed; then six industry case studies are presented which illustrate the practical use of EKEBNs. Domain experts from each company participated in the elicitation of the bespoke models for effort estimation and all models were built employing the widely-used Netica ¿ tool. This part is rounded off with a chapter summarizing the experiences with the methodology and the derived models.Practitioners working on software project management, software process qualityor effort estimation and risk analysis in general will find a thorough introduction into an industry-proven methodology as well as numerous experiences, tips and possible pitfalls invaluable for their daily work.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 224 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This two-volume-set (LNCS 8384 and 8385) constitutes the refereed proceedings of the 10th International Conference of Parallel Processing and Applied Mathematics, PPAM 2013, held in Warsaw, Poland, in September 2013. The 143 revised full papers presented in both volumes were carefully reviewed and selected from numerous submissions. The papers cover important fields of parallel/distributed/cloud computing and applied mathematics, such as numerical algorithms and parallel scientific computing; parallel non-numerical algorithms; tools and environments for parallel/distributed/cloud computing; applications of parallel computing; applied mathematics, evolutionary computing and metaheuristics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 840 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book constitutes the thoroughly refereed proceedings of the 4th International Conference on Abstract State Machines, B, TLA, VDM and Z, which took place in Toulouse, France, in June 2014. The 13 full papers presented together with 3 invited talks and 19 short papers were carefully reviewed and selected from 81 submissions. The ABZ conference series is dedicated to the cross-fertilization of six related state-based and machine-based formal methods: Abstract State Machines (ASM), Alloy, B, TLA, VDM and Z. They share a common conceptual foundation and are widely used in both academia and industry for the design and analysis of hardware and software systems. The main goal of this conference series is to contribute to the integration of these formal methods, clarifying their commonalities and differences to better understand how to combine different approaches for accomplishing the various tasks in modeling, experimental validation and mathematical verification of reliable high-quality hardware/software systems.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 352 pp. Englisch.

Buch. Condizione: Neu. Neuware -One of the most significant challenges in the development of embedded and cyber-physical systems is the gap between the disciplines of software and control engineering. In a marketplace, where rapid innovation is essential, engineers from both disciplines need to be able to explore system designs collaboratively, allocating responsibilities to software and physical elements, and analyzing trade-offs between them.To this end, this book presents a framework that allows the very different kinds of design models ¿ discrete-event (DE) models of software and continuous time (CT) models of the physical environment ¿ to be analyzed and simulated jointly, based on common scenarios. The individual chapters provide introductions to both sides of this co-simulation technology, and give a step-by-step guide to the methodology for designing and analyzing co-models. They are grouped into three parts: Part I introduces the technical basis for collaborative modeling and simulation with the Crescendo technology. Part II continues with different methodological guidelines for creating co-models and analyzing them in different ways using case studies. Part III then delves into more advanced topics and looks into the potential future of this technology in the area of cyber-physical systems. Finally various appendices provide summaries of the VDM and 20-sim technologies, a number of valuable design patterns applicable for co-models, and an acronym list along with indices and references to other literature. By combining descriptions of the underlying theory with records of real engineers¿ experience in using the framework on a series of case studies the book appeals to scientists and practitioners alike. It is complemented by tools, examples, videos, and other material on crescendotool.org.Scientists/researchers and graduate students working in embedded and cyber-physical systems will learn the semantic foundations for collaborative modeling and simulation,as well as the current capabilities and limitations of methods and tools in this field. Practitioners will be able to develop an appreciation of the capabilities of the co-modeling techniques, to assess the benefits of more collaborative approaches to modeling and simulation, and will benefit from the included guidelines and modeling patterns.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 408 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This volume constitutes the refereed post-workshop proceedings of two IFIP WG 13.7 workshops on Human-Computer Interaction and Visualization: the 7th HCIV Workshop on Non-formal Modelling for Interaction Design, held at the 29th European Conference on Cognitive Ergonomics, ECCE 2011, in Rostock, Germany, in August 2011 and the 8th HCIV Workshop on HCI and Visualization, held at the 13th IFIP TC 13 Conference on Human-Computer Interaction, INTERACT 2011, in Lisbon, Portugal, in September 2011. The 15 revised papers presented were carefully reviewed and selected for inclusion in this volume. They cover a wide range of topics in the fields of non-formal modeling, visualization and HCI and provide visions from researchers working at or across the borders between these domains that may help develop a holistic cross-discipline.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 240 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book constitutes the revised selected papers of the workshops of the 10th and 11th International Conference of Web-based Learning, ICWL 2011, held in Hong Kong, in December 2011 and ICWL 2012, held in Sinaia, Romania, in September 2012.This volume comprises papers from one symposium that took place both in 2011 and 2012 and four workshops (two from 2011 and two from 2012):1. The 1st and 2nd International Symposium on Knowledge Management and E-Learning (KMEL2011 / 2012);2. The 1st International Workshop on Enhancing Learning with Social (ELSM 2011);3. The 4th International Workshop on Social and Personal Computing for Web-Supported Learning (SPeL 2011);4. International Workshop on Learning within and from Smart Cities (SciLearn 2012);5. International Workshop on Creative Collaboration through Supportive Technologies in Education (CCSTED 2012).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 388 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book constitutes the proceedings of the 34th IFIP WG 6.1 International Conference on Formal Techniques for Distributed Objects, Components and Systems, FORTE 2014, held in Berlin, Germany, in June 2014, as part of the 9th International Federated Conference on Distributed Computing Techniques, DisCoTec 2014. The 18 revised full papers presented were carefully reviewed and selected from 50 submissions. The papers present a wide range of topics on specification languages and type systems, monitoring and testing, security analysis and bisimulation, abstraction and reduction.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 316 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This two-volume-set (LNCS 8384 and 8385) constitutes the refereed proceedings of the 10th International Conference of Parallel Processing and Applied Mathematics, PPAM 2013, held in Warsaw, Poland, in September 2013. The 143 revised full papers presented in both volumes were carefully reviewed and selected from numerous submissions. The papers cover important fields of parallel/distributed/cloud computing and applied mathematics, such as numerical algorithms and parallel scientific computing; parallel non-numerical algorithms; tools and environments for parallel/distributed/cloud computing; applications of parallel computing; applied mathematics, evolutionary computing and metaheuristics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 804 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book constitutes the refereed proceedings of the 7th International Conference on Quantum Interaction, QI 2013, held in Leicester, UK, in July 2013. The 31 papers presented in this book were carefully selected from numerous submissions. The papers cover various topics on quantum interaction and revolve around four themes: information processing/retrieval/semantic representation and logic; cognition and decision making; finance/economics and social structures and biological systems.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 364 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Compared to other main groups of procurement, capital equipment features numerous characteristics that significantly impact the purchasing process. The process of purchasing capital equipment therefore requires specific attention and above all a systematic approach. To overcome these challenges, a holistic process model and specific tools and methods for capital equipment purchasing are presented.The following topics regarding capital equipment purchasing are presented:¿ Compliance management¿ Savings measurement¿ Life cycle costs and total cost of ownership¿ Determining the optimum useful life and replacement time¿ Real options approach for the evaluation of investment alternatives¿ Performance contractingReaders are provided with a comprehensive and structured process model for capital equipment purchasing. The comprehensive set of methods including various instruments and methods presented in this book support the establishment of a professional capital equipment purchasing process.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 136 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Economies around the globe have evolved into being largely service-oriented economies. Consumers no longer just want a printer or a car, they rather ask for a printing service or a mobility service. In addition, service-oriented organizations increasingly exploit new devices, technologies and infrastructures. Agility is the ability to deal with such changing requirements and environments. Agile ways of working embrace change as a positive force and harness it to the organization's competitive advantage.The approach described in this book focuses on the notion of a service as a piece of functionality that offers value to its customers. Instead of solely looking at agility in the context of system or software development, agility is approached in a broader context. The authors illustrate three kinds of agility that can be found in an agile enterprise: business, process and system agility. These three types of agility reinforce each other and establish the foundation for the agile enterprise. Architecture, patterns, models, and all of the best practices in system development contribute to agile service development and building agile applications.This book addresses two audiences. On the one hand, it aims at agile and architecture practitioners who are looking for more agile ways of working in designing and building business services or who are interested in extending and improving their agile methods by using models and model-based architectures. On the other hand, it addresses students of (enterprise) architecture and software development or service science courses, both in computer science and in business administration.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 224 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Ability to learn from errors is an essential aspect of the quest to improve treatment quality and patient safety. This book consists of 33 cases in anesthesiology thatis based on real life situations and illuminate avoidable complications and mishaps. The cases are presented in a novel manner in that they are embedded within narratives. The reader comes to each case ¿cold¿, without any clue as to the content, and each case comprises a narrative and a factual component that are interwoven. The narrative parts provide the reader with information and tips regarding the clinical problems and tasks that the protagonist must face and try to solve. The idea is to engage the reader emotionally while reading and to entertain him or her while learning. All cases conclude with short debriefing sections which include possible strategies to prevent similar errors or mishaps.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 392 pp. Englisch.

Buch. Condizione: Neu. Neuware -A great nation has a great dream; a great country has a great dream. Chinäs dream is to build a society of common prosperity and a world in which all people live together in peace and harmony.This book provides predictions up to 2030 regarding the future major developments and trends of both China and the world in general from a historical and worldwide perspective. This book spells out the dreams of all mankind in the pursuit of common prosperity. It also offers Chinäs vision and perspective to the world, as well as Chinese scholars¿ perspective on and worldwide vision for the future.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 160 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book approaches macroprudential oversight from the viewpoint of three tasks. The focus concerns a tight integration of means for risk communication into analytical tools for risk identification and risk assessment. Generally, this book explores approaches for representing complex data concerning financial entities on low-dimensional displays. Data and dimension reduction methods, and their combinations, hold promise for representing multivariate data structures in easily understandable formats. Accordingly, this book creates a Self-Organizing Financial Stability Map (SOFSM), and lays out a general framework for mapping the state of financial stability. Beyond external risk communication, the aim of the visual means is to support disciplined and structured judgmental analysis based upon policymakers' experience and domain intelligence.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book provides a comprehensive review of the Measures for Administration of Takeover of Chinese Listed Companies (the Chinese takeover law), with emphasis on the differences between the Chinese takeover law and takeover legislation in the UK, the US and Hong Kong. The Chinese M&A market has been booming at an unprecedented rate in recent years; not only domestic investors, but also foreign funds and multinational companies are actively participating on the market. For both market participants and researchers, it is crucial to understand the emerging and transitional aspects of the Chinese economy and its M&A market, and the impacts of those aspects on relevant laws. While there are ongoing academic discussions on the convergence between the Chinese takeover law and its counterparts in the UK, Hong Kong and the US, this book offers a comprehensive discussion of the divergence and focuses on key differences in the transplanted Chinese takeover law.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 208 pp. Englisch.

Buch. Condizione: Neu. Neuware -Emerging to the forefront of sustainable production and consumption are a promising and rapidly evolving concept known as Voluntary Standard Systems (VSS). They encompass the three pillars of sustainability ¿ social, environmental and economic aspects and consequently they can be considered as a tool, which makes sustainable development visible. Currently, they are becoming a significant element in international trade and in the promotion of sustainable development strategies, especially in the context of globalised markets and supply chains.This volume provides a comprehensive overview of the current VSS concepts: from their nature and functioning, to the future outlook for their development. It places VSS in the broader context of global development issues and challenges, including development policy and international sustainability commitments, progress towards achieving ¿green economy¿ and meeting climate protection targets. The volume contains also a representative selection of case studies which demonstrate their wide range of application in different sectors of the economy.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 476 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -The study of power is the nucleus of political science and international relations. As a shift of power from traditional industrial countries to emerging powers has been perceived since the turn of the century, this book aims to present innovative theoretical and empirical approaches that can increase our understanding of this transition. Scholars from the fields of international relations, international political economy, economics and security studies not only explore current theoretical debates on ¿power¿ and ¿power shifts¿ among entities, but also provide fresh insights into relevant aspects of international power in the 21st century. With a particular focus on aspects of international security, trade and production, new methods of identifying power and its sources are presented, and their potential implications and challenges are discussed.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 340 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -As the sluggish external market demand and excess domestic investment in past years have caused excess production capacity, resulting in both industrial growth rate and GDP growth rate falling to lowest point for the last three years in China. Where would Chinäs economy go Chinäs Macroeconomic Outlook, September 2013 provides some insights into the details of the economic development in China, and also includes series of simulations of the impact of decreasing government revenue on the economic performance. The research suggests that China should cut its government revenue share in GDP to promote its structural adjustment.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 72 pp. Englisch.

Buch. Condizione: Neu. Neuware -This publication provides an unparalleled comparative analysis of two 'hot topics' in the field of antitrust and unfair competition laws with regard to a number of key countries.The first part of the book examines whether small and middle-sized businesses could or should be subject to specific competition rules. These businesses account for 99% of the enterprises in Europe and the United States, making this a particularly important topic. The papers consider both the public and private enforcement rules across a range of jurisdictions and a detailed international report, prepared by Michele Carpagnano, identifies general trends and highlights differences and the most interesting features of national regulations.The second part of the book gathers contributions from various jurisdictions on the unfair competition question of whether a company could or should be protected against the use of their trademark, distinctive signs and other components of their image and identity on the part of non-competing companies. The papers focus on the fundamental issue of the competitive relationship as a condition of protection under unfair competition acts and the connection to intellectual property protection. The comprehensive and insightful international report, prepared by Martine Karsenty-Ricard, brings together these reflections by comparing various national positions.The book also includes the resolutions passed by the General Assembly of the LIDC following a debate on each of these topics, which include proposed solutions and recommendations. The International League of Competition Law (LIDC) is a long-standing international association that focuses on the interface between competition law and intellectual property law, including unfair competition issues.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 480 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book introduces two of the most exciting heat pumping technologies, the coabsorbent and the thermal recovery (mechanical vapor) compression, characterized by a high potential in primary energy savings and environmental protection. New cycles with potential applications of nontruncated, truncated, hybrid truncated, and multi-effect coabsorbent types are introduced in this work.Thermal-to-work recovery compression (TWRC) is the first of two particular methods explored here, including how superheat is converted into work, which diminishes the compressor work input. In the second method, thermal-to-thermal recovery compression (TTRC), the superheat is converted into useful cooling and/or heating, and added to the cycle output effect via the coabsorbent technology. These and other methods of discharge gas superheat recovery are analyzed for single-, two-, three-, and multi-stage compression cooling and heating, ammonia and ammonia-water cycles, and the effectiveness results are given.The author presents absorption-related topics, including the divided-device method for mass and heat transfer analysis, and truncation as a unique method for a better source-task match. Along with advanced gax recovery, the first and second principles of COP and exergy calculation, the ideal point approaching (i.p.a.) effect and the two-point theory of mass and heat transfer, the book also addresses the new wording of the Laplace equation, the Marangoni effect true explanation, and the new mass and heat exchangers based on this effect.The work goes on to explore coabsorbent separate and combined cooling, heating, and power (CHP) production and advanced water-lithium bromide cycle air-conditioning, as well as analyzing high-efficiency ammonia-water heat-driven heating and industrial low-temperature cooling, in detail.Readers will learn how coabsorbent technology is based on classic absorption, but is more general. It is capable of offeringeffective solutions for all cooling and heating applications (industry, agriculture, district, household, etc.), provided that two supplying heat-sink sources with temperatures outdistanced by a minimum of 12-15ºC are available.This book has clear and concise presentation and illustrates the theory and applications with diagrams, tables, and flowcharts.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 540 pp. Englisch.

Buch. Condizione: Neu. Neuware -This contributed volume presents computational models of diabetes that quantify the dynamic interrelationships among key physiological variables implicated in the underlying physiology under a variety of metabolic and behavioral conditions. These variables comprise for example blood glucose concentration and various hormones such as insulin, glucagon, epinephrine, norepinephrine as well as cortisol. The presented models provide a powerful diagnostic tool but may also enable treatment via long-term glucose regulation in diabetics through closed-look model-reference control using frequent insulin infusions, which are administered by implanted programmable micro-pumps. This research volume aims at presenting state-of-the-art research on this subject and demonstrating the potential applications of modeling to the diagnosis and treatment of diabetes. The target audience primarily comprises research and experts in the field but the book may also be beneficial for graduate students.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 248 pp. Englisch.

Buch. Condizione: Neu. Neuware -Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 436 pp. Englisch.