springer netherlands jun 2016 (30 risultati)

Buch. Condizione: Neu. Neuware -This book provides a comprehensive overview of contemporary issues in complementary metal-oxide semiconductor (CMOS) device design, describing how to overcome process-induced random variations such as line-edge-roughness, random-dopant-fluctuation, and work-function variation, and the applications of novel CMOS devices to cache memory (or Static Random Access Memory, SRAM). The author places emphasis on the physical understanding of process-induced random variation as well as the introduction of novel CMOS device structures and their application to SRAM.The book outlines the technical predicament facing state-of-the-art CMOS technology development, due to the effect of ever-increasing process-induced random/intrinsic variation in transistor performance at the sub-30-nm technology nodes. Therefore, the physical understanding of process-induced random/intrinsic variations and the technical solutions to address these issues plays a key role in new CMOS technology development.This book aims to provide the reader with a deep understanding of the major random variation sources, and the characterization of each random variation source. Furthermore, the book presents various CMOS device designs to surmount the random variation in future CMOS technology, emphasizing the applications to SRAM.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 148 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book approaches the concept of adjustment to aging and endeavors to build reader understanding of this construct through a critical review and discussion. Once the reader understands the origins and nature of adjustment to aging, a second innovation encompasses the development of a proposed empirical model of adjustment to aging and the analysis of its components and correlates. Measures to assess adjustment to aging, policies, programs and interventions comprising adjustment to aging and its components and correlates will also be addressed. Another innovation includes the multidimensional experience of adjustment to aging from the cultural perspective. Lastly, it addresses areas of future development related to this construct.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 284 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book provides a comprehensive introduction to a recently-developed approach to the growth mechanism of thin films and nanostructures via chemical vapour deposition (CVD). Starting from the underlying principles of the low pressure synthesis of diamond films, it is shown that diamond growth occurs not by individual atoms but by charged nanoparticles. This newly-discovered growth mechanism turns out to be general to many CVD and some physical vapor deposition (PVD) processes. This non-classical crystallization is a new paradigm of crystal growth, with active research taking place on growth in solution, especially in biomineralization processes.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 344 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume opens up new perspectives on the physics of the Earth¿s interior and planetary bodies for graduate students and researchers working in the fields of geophysics, planetary sciences and geodesy. It looks at our planet in an integrated fashion, linking the physics of its interior to geophysical and geodetic techniques that record, over a broad spectrum of spatial wavelengths and time scales, the ongoing modifications in the shape and gravity field of the planet. Basic issues related to the rheological properties of the Earth and to its slow deformation are considered, in both mathematical and physical terms, within the framework of an analytical relaxation theory. Fundamentals of this theory are developed in the first two Chapters. Chapters 3-9 deal with a wide range of applications, ranging from changes in the Earth¿s rotation to post-seismic deformation and from sea-level variations induced by post-glacial rebound to tidal deformation of icy moons of the Solar System. This Second Edition improves substantially our formalism implementing compressibility in viscoelastic relaxation. Chapter 5 now contains new developments in the physics of the gravitational effects of large earthquakes at subduction zones, made possible by new gravity data from space missions. The new Chapter 9 of this Second Edition on deformation and stresses of icy moons enlarges the applications of the book to Planetology, dealing with the additional complications in the theory of viscoelastic relaxation introduced by the shallow low-viscosity zones and inviscid water layers of the moons of Jupiter and Saturn.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 376 pp. Englisch.

Buch. Condizione: Neu. Neuware -The objective of this volume is to showcase the contemporary state of research on recognizing and evaluating the performance of stone age weapons from a variety of viewpoints, including investigating their cognitive and evolutionary significance.New archaeological finds and experimental studies have helped to bring this subject back to the forefront of human origins research. In the last few years, investigations have expanded beyond examining the tools themselves to include studies of damage caused by projectile weapons on animal and hominin bones and skeletal asymmetries in ancient hominin populations. Only recently has there been a growing interest in controlled and replicative experiments. Through this book readers will be updated in the state of knowledge through a multidisciplinary scientific reconstruction of prehistoric weapon use and its implications.Contributions from expert authors are organized into three themed parts: recognizing weapon use (experimental and archaeological studies of impact traces), performance of weapon systems (factors influencing penetration depth etc.), and behavioral and evolutionary ramifications (cognitive and ecological effects of using different weapons).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 324 pp. Englisch.

Buch. Condizione: Neu. Neuware -The research and its outcomes presented in this book treat applications of NDT techniques to on-site measurements. These on-site measurementshave been marginally successful aseach technique requires a particular analysis. In this regard, visualization and imaging of results are in great demand for practitioners and engineers for inspection. This volume, in which on-site measurements of concrete and masonry structures by NDT techniques are comprehensively summarized, focuses on the visualization procedure of the results measured. The bookwill therefore be of great value to the field.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 192 pp. Englisch.

Buch. Condizione: Neu. Neuware -This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines.A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that ¿a picture tells more than thousand words¿.The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 228 pp. Englisch.

Buch. Condizione: Neu. Neuware -Marine environmental history analyses the changing relationships between human societies and marine natural resources over time. This is the first book which deals in a systematic way with the theoretical backgrounds of this discipline. Major theories and methods are introduced by leading scholars of the field. The book seeks to encapsulate some of the major novelties of this fascinating new discipline and its contribution to the management, conservation and restoration of marine and coastal ecosystems as well as the cultural heritages of coastal communities in different parts of the world.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 224 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book presents recent advances in understanding the physiological and molecular mechanisms of different abiotic stresses such as high or low temperature, salinity, drought, flooding, soil acidity, heavy metals, light stress and ozone stress, and discusses the multifaceted role of phytohormones in stress adaptation and the underlying mechanisms. Aimed at students and researchers in the field of plant science, it offers a comprehensive overview of the versatile roles and interactions of different phytohormones in response to a specific stress factor and examines the possible physiological and molecular mechanisms that have been the subject of recent research.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 288 pp. Englisch.

Buch. Condizione: Neu. Neuware -The title ¿Phosphorus in Agriculture: 100 % Zerö is synonymous for make-or-break. And it stands up to the promise. This book sends an important message as it delivers background information, intrinsic hypotheses, validation approaches and legal frameworks, all for balanced phosphorus fertilization in agriculture. This implies firstly that the phosphorus requirement of crop is fully satisfied by applying exclusively fertilizers which contain the nutrient in completely available form. Secondly, environmental demands through eutrophication and hazardous contaminants must not be compromised. The book identifies equally knowledge gaps and deficits in the transformation and implementation of research into practice. Bottom line is that research delivers the tools for a sustainable phosphorus management while legal frameworks are insufficient.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 368 pp. Englisch.

Buch. Condizione: Neu. Neuware -Thisbook provides readers an extensive overview of recent progress in basicand clinical research on cancer immunotherapy. Thanks to rapid advances inmolecular biology and immunology, it has become increasingly evident thatcancer growth is influenced by host immune responses. With the success of anumber of clinical trials, immunotherapy has become a promising treatmentmodality of cancer. This book covers five major topics, including monoclonalantibodies, biological response modifiers, cancer vaccines, adoptive cellulartherapy and oncolytic viruses. It also examines the combination of differentimmune strategies as well as the combination of immunotherapy with othertreatments to increase anti-tumor effects. Throughthecomprehensive discussion of the topic, the book sheds valuable new light on thetreatment of tumors.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book walks the reader through the next step in the evolution of NAND flash memory technology, namely the development of 3D flash memories, in which multiple layers of memory cells are grown within the same piece of silicon. It describes their working principles, device architectures, fabrication techniques and practical implementations, and highlights why 3D flash is a brand new technology.After reviewing market trends for both NAND and solid state drives (SSDs), the book digs into the details of the flash memory cell itself, covering both floating gate and emerging charge trap technologies. There is a plethora of different materials and vertical integration schemes out there. New memory cells, new materials, new architectures (3D Stacked, BiCS and P-BiCS, 3D FG, 3D VG, 3D advanced architectures); basically, each NAND manufacturer has its own solution. Chapter 3 to chapter 7 offer a broad overview of how 3D can materialize. The 3D wave is impacting emerging memories as well and chapter 8 covers 3D RRAM (resistive RAM) crosspoint arrays. Visualizing 3D structures can be a challenge for the human brain: this is way all these chapters contain a lot of bird¿s-eye views and cross sections along the 3 axes.The second part of the book is devoted to other important aspects, such as advanced packaging technology (i.e. TSV in chapter 9) and error correction codes, which have been leveraged to improve flash reliability for decades. Chapter 10 describes the evolution from legacy BCH to the most recent LDPC codes, while chapter 11 deals with some of the most recent advancements in the ECC field. Last but not least, chapter 12 looks at 3D flash memories from a system perspective.Is 14nm the last step for planar cells Can 100 layers be integrated within the same piece of silicon Is 4 bit/cell possible with 3D Will 3D be reliable enough for enterprise and datacenter applications These are some of the questions that this book helps answering by providing insights into 3D flash memory design, process technology and applications.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 404 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book explores the concept of 'occupation' in disability well beyond traditional clinical formulations of disability: it considers disability not in terms of pathology or impairment, but as a range of unique social identities and experiences that are shaped by visible or invisible diagnoses/impairments, socio-cultural perceptions and environmental barriers and offers innovative ideas on how to apply theoretical training to real world contexts. Inspired by disability justice and ¿Disability Occupy Wall Street / Decolonize Disability¿ movements in the US and related movements abroad, this book builds on politically engaged critical approaches to disability that intersect occupational therapy, disability studies and anthropology. 'Occupying Disability' will provide a discursive space where the concepts of disability, culture and occupation meet critical theory, activism and the creative arts. The concept of ¿occupation¿ is intentionally a moving target in this book. Some chapters discuss occupying spaces as a form of protest or alternatively, protesting against territorial occupations. Others present occupations as framed or problematized within the fields of occupational therapy and occupational science and anthropology as engagement in meaningful activities. The contributing authors come from a variety of professional, academic and activist backgrounds to include perspectives from theory, practice and experiences of disability. Emergent themes include: all the permutations of the concept of 'occupy,' disability justice/decolonization, marginalization and minoritization, technology, struggle, creativity and change. This book will engage clinicians, social scientists, activists and artists in dialogues about disability as a theoretical construct and lived experience.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 408 pp. Englisch.

Buch. Condizione: Neu. Neuware -An Introduction that describes the origin of cytochrome notation also connects to the history of the field, focusing on research in England in the pre-World War II era. The start of the modern era of studies on structure-function of cytochromes and energy-transducing membrane proteins was marked by the 1988 Nobel Prize in Chemistry, given to J. Deisenhofer, H. Michel, and R. Huber for determination of the crystal structure of the bacterial photosynthetic reaction center. An ab initio logic of presentation in the book discusses the evolution of cytochromes and hemes, followed by theoretical perspectives on electron transfer in proteins and specifically in cytochromes. There is an extensive description of the molecular structures of cytochromes and cytochrome complexes from eukaryotic and prokaryotic sources, bacterial, plant and animal. The presentation of atomic structure information has a major role in these discussions, and makes an important contribution to the broad field of membrane protein structure-function.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 788 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book approaches the concept of adjustment to aging and endeavors to build reader understanding of this construct through a critical review and discussion. Once the reader understands the origins and nature of adjustment to aging, a second innovation encompasses the development of a proposed empirical model of adjustment to aging and the analysis of its components and correlates. Measures to assess adjustment to aging, policies, programs and interventions comprising adjustment to aging and its components and correlates will also be addressed. Another innovation includes the multidimensional experience of adjustment to aging from the cultural perspective. Lastly, it addresses areas of future development related to this construct.Future policies and interventions in older populations need to integrate and debate the role of adjustment to aging, and ultimately consider a variety of different strategies, each with a different set of costs and benefits. Health and social professionals will be at the vanguard of policy making and community and institutional interventions. Hence, resources and tools to adequately prepare these individuals for the future years will be vital. It is the author's hope that this resource can be valuable for professionals and students working within the field of aging, as they develop research and intervention policies encompassing adjustment to aging in the coming years. 284 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides a comprehensive overview of contemporary issues in complementary metal-oxide semiconductor (CMOS) device design, describing how to overcome process-induced random variations such as line-edge-roughness, random-dopant-fluctuation, and work-function variation, and the applications of novel CMOS devices to cache memory (or Static Random Access Memory, SRAM). The author places emphasis on the physical understanding of process-induced random variation as well as the introduction of novel CMOS device structures and their application to SRAM. The book outlines the technical predicament facing state-of-the-art CMOS technology development, due to the effect of ever-increasing process-induced random/intrinsic variation in transistor performance at the sub-30-nm technology nodes. Therefore, the physical understanding of process-induced random/intrinsic variations and the technical solutions to address these issues plays a key role in new CMOS technology development. This book aims to provide the reader with a deep understanding of the major random variation sources, and the characterization of each random variation source. Furthermore, the book presents various CMOS device designs to surmount the random variation in future CMOS technology, emphasizing the applications to SRAM. 148 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This work considers the potential of photographs for orienting in a critical direction the scope, questions and interests of the disciplinary conventions of the field of educational inquiry. Visual objects may help illuminate broader socio-historical events and logics that are deeply entwined with education yet remain marginal to or 'outside' of what constitutes its domain of study. In this work photographic images are treated as resources for re-visioning the founding disciplinary objects of educational studies by reorienting its proper objects of study, traditional archives, persistent categories, frames of reference, and accepted portals of research and inquiry. A theoretic framing shapes the question taken up in this work, 'How might an engagement with photo-archives open new horizons in the study of education from a postfoundationalist, multi-theoretic and cross-disciplinary perspective ' The author constructs a rather unconventional vantage point to explore this question that opens on to the discursive spaces of three photographs made of three women in the years 1897, 1949, and 1966. The photographs are analysed from three theoretic approaches. First, it is indicated how each photographic image not only marks a relationship to the past, the present, and the future but to the rules and conventions of photographic practices. These particular images give an account of what both persists and exceeds the photographic image, and permit to rewrite the bodies and lives pictured. Second, the subject matter of each photographic image while singular and local bears witness to the complex network of racial, patriarchal and colonial logics and their profound imbrication with a 'technically mediated inscription.' For all their singularity the photographs cannot but evoke their relation to the deeply historical character of photography. Finally, the photographs make possible an account of broader occurrences, subterranean histories, contexts, and differently situatedexperiences that illuminate, much like the principle of montage, a sequence of overlapping events crosscutting with one another consequently throwing open the possibility of responding to and transforming the histories and archives we are given.This book 'Pedagogies of the Image' is a winner of the 2017 American Educational Studies Association Critics' Choice Award 116 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This work considers the potential of photographs for orienting in a critical direction the scope, questions and interests of the disciplinary conventions of the field of educational inquiry. Visual objects may help illuminate broader socio-historical events and logics that are deeply entwined with education yet remain marginal to or ¿outside¿ of what constitutes its domain of study. In this work photographic images are treated as resources for re-visioning the founding disciplinary objects of educational studies by reorienting its proper objects of study, traditional archives, persistent categories, frames of reference, and accepted portals of research and inquiry. A theoretic framing shapes the question taken up in this work, 'How might an engagement with photo-archives open new horizons in the study of education from a postfoundationalist, multi-theoretic and cross-disciplinary perspective ' The author constructs a rather unconventional vantage point to explore this question that opens on to the discursive spaces of three photographs made of three women in the years 1897, 1949, and 1966. The photographs are analysed from three theoretic approaches. First, it is indicated how each photographic image not only marks a relationship to the past, the present, and the future but to the rules and conventions of photographic practices. These particular images give an account of what both persists and exceeds the photographic image, and permit to rewrite the bodies and lives pictured. Second, the subject matter of each photographic image while singular and local bears witness to the complex network of racial, patriarchal and colonial logics and their profound imbrication with a 'technically mediated inscription.' For all their singularity the photographs cannot but evoke their relation to the deeply historical character of photography. Finally, the photographs make possible an account of broader occurrences, subterranean histories, contexts, and differently situatedexperiences that illuminate, much like the principle of montage, a sequence of overlapping events crosscutting with one another consequently throwing open the possibility of responding to and transforming the histories and archives we are given.This book 'Pedagogies of the Image' is a winner of the2017 American Educational Studies Association Critics' Choice AwardSpringer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 116 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides a comprehensive introduction to a recently-developed approach to the growth mechanism of thin films and nanostructures via chemical vapour deposition (CVD). Starting from the underlying principles of the low pressure synthesis of diamond films, it is shown that diamond growth occurs not by individual atoms but by charged nanoparticles. This newly-discovered growth mechanism turns out to be general to many CVD and some physical vapor deposition (PVD) processes. This non-classical crystallization is a new paradigm of crystal growth, with active research taking place on growth in solution, especially in biomineralization processes.Established understanding of the growth of thin films and nanostructures is based around processes involving individual atoms or molecules. According to the author's research over the last two decades, however, the generation of charged gas phase nuclei is shown to be the rule rather than the exception in the CVD process, and charged gas phase nuclei are actively involved in the growth of films or nanostructures. This new understanding is called the theory of charged nanoparticles (TCN). This book describes how the non-classical crystallization mechanism can be applied to the growth of thin films and nanostructures in gas phase synthesis. Based on the author's graduate lecture course, the book is aimed at senior undergraduate and graduate students and researchers in the field of thin film and nanostructure growth or crystal growth. It is hoped that a new understanding of the growth processes of thin films and nanostructures will reduce trial-and-error in research and in industrial fabrication processes. 344 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The research and its outcomes presented in this book treat applications of NDT techniques to on-site measurements. These on-site measurements have been marginally successful as each technique requires a particular analysis. In this regard, visualization and imaging of results are in great demand for practitioners and engineers for inspection. This volume, in which on-site measurements of concrete and masonry structures by NDT techniques are comprehensively summarized, focuses on the visualization procedure of the results measured. The book will therefore be of great value to the field. 192 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume opens up new perspectives on the physics of the Earth's interior and planetary bodies for graduate students and researchers working in the fields of geophysics, planetary sciences and geodesy. It looks at our planet in an integrated fashion, linking the physics of its interior to geophysical and geodetic techniques that record, over a broad spectrum of spatial wavelengths and time scales, the ongoing modifications in the shape and gravity field of the planet. Basic issues related to the rheological properties of the Earth and to its slow deformation are considered, in both mathematical and physical terms, within the framework of an analytical relaxation theory. Fundamentals of this theory are developed in the first two Chapters. Chapters 3-9 deal with a wide range of applications, ranging from changes in the Earth's rotation to post-seismic deformation and from sea-level variations induced by post-glacial rebound to tidal deformation of icy moons of the Solar System. This Second Edition improves substantially our formalism implementing compressibility in viscoelastic relaxation. Chapter 5 now contains new developments in the physics of the gravitational effects of large earthquakes at subduction zones, made possible by new gravity data from space missions. The new Chapter 9 of this Second Edition on deformation and stresses of icy moons enlarges the applications of the book to Planetology, dealing with the additional complications in the theory of viscoelastic relaxation introduced by the shallow low-viscosity zones and inviscid water layers of the moons of Jupiter and Saturn. 376 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The objective of this volume is to showcase the contemporary state of research on recognizing and evaluating the performance of stone age weapons from a variety of viewpoints, including investigating their cognitive and evolutionary significance.New archaeological finds and experimental studieshave helped to bring this subject back to the forefront of human origins research. In the last few years, investigations have expanded beyondexamining the tools themselves to include studies of damage caused by projectile weapons on animal and hominin bones and skeletal asymmetries in ancient hominin populations. Only recently has there been a growing interest in controlled and replicative experiments. Through this book readers will beupdated in the state of knowledge through a multidisciplinary scientific reconstruction of prehistoric weapon use and its implications.Contributions from expert authors are organized into three themed parts: recognizing weapon use (experimental and archaeological studies of impact traces), performance of weapon systems (factors influencing penetration depth etc.), and behavioral and evolutionary ramifications (cognitive and ecological effects of using different weapons). 324 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This textbook aims to describethe fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines.A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that 'a picture tells more than thousand words'. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook,Mechanisms of Gene Regulationwill be a useful reference for individuals working in biomedical laboratories. 228 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Marine environmental history analyses the changing relationships between human societies and marine natural resources over time. This is the first book which deals in a systematic way with the theoretical backgrounds of this discipline. Major theories and methods are introduced by leading scholars of the field. The book seeks to encapsulate some of the major novelties of this fascinating new discipline and its contribution to the management, conservation and restoration of marine and coastal ecosystems as well as the cultural heritages of coastal communities in different parts of the world. 224 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware - This book presents recent advances in understanding the physiological and molecular mechanisms of different abiotic stresses such as high or low temperature, salinity, drought, flooding, soil acidity, heavy metals, light stress and ozone stress, and discusses the multifaceted role of phytohormones in stress adaptation and the underlying mechanisms. Aimed at students and researchers in the field of plant science, it offers a comprehensive overview of the versatile roles and interactions of different phytohormones in response to a specific stress factor and examines the possible physiological and molecular mechanisms that have been the subject of recent research. 288 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The title 'Phosphorus in Agriculture: 100 % Zero' is synonymous for make-or-break. And it stands up to the promise. This book sends an important message as it delivers background information, intrinsic hypotheses, validation approaches and legal frameworks, all for balanced phosphorus fertilization in agriculture. This implies firstly that the phosphorus requirement of crop is fully satisfied by applying exclusively fertilizers which contain the nutrient in completely available form. Secondly, environmental demands through eutrophication and hazardous contaminants must not be compromised. The book identifies equally knowledge gaps and deficits in the transformation and implementation of research into practice. Bottom line is that research delivers the tools for a sustainable phosphorus management while legal frameworks are insufficient. 368 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thisbook provides readers an extensive overview ofrecent progress in basicand clinical research on cancer immunotherapy. Thanks to rapid advances inmolecular biology and immunology, it has become increasingly evident thatcancer growth is influenced by host immune responses. With the success of anumber of clinical trials, immunotherapy has become a promising treatmentmodality of cancer. This book covers five major topics, including monoclonalantibodies, biological response modifiers, cancer vaccines, adoptive cellulartherapy and oncolytic viruses. It also examines the combination of differentimmune strategies as well asthe combination of immunotherapy with othertreatments to increase anti-tumor effects. Throughthecomprehensive discussion of the topic, the book sheds valuable new light on thetreatment of tumors. 296 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book explores the concept of 'occupation' in disability well beyond traditional clinical formulations of disability: it considers disability not in terms of pathology or impairment, but as a range of unique social identities and experiences that are shaped by visible or invisible diagnoses/impairments, socio-cultural perceptions and environmental barriers and offers innovative ideas on how to apply theoretical training to real world contexts. Inspired by disability justice and 'Disability Occupy Wall Street / Decolonize Disability' movements in the US and related movements abroad, this book builds on politically engaged critical approaches to disability that intersect occupational therapy, disability studies and anthropology. 'Occupying Disability' will provide a discursive space where the concepts of disability, culture and occupation meet critical theory, activism and the creative arts. The concept of 'occupation' is intentionally a moving target in this book. Some chapters discuss occupying spaces as a form of protest or alternatively, protesting against territorial occupations. Others present occupations as framed or problematized within the fields of occupational therapy and occupational science and anthropology as engagement in meaningful activities. The contributing authors come from a variety of professional, academic and activist backgrounds to include perspectives from theory, practice and experiences of disability. Emergent themes include: all the permutations of the concept of 'occupy,' disability justice/decolonization, marginalization and minoritization, technology, struggle, creativity and change. This book will engage clinicians, social scientists, activists and artists in dialogues about disability as a theoretical construct and lived experience. 408 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book walks the reader through the next step in the evolution of NAND flash memory technology, namely the development of 3D flash memories, in which multiple layers of memory cells are grown within the same piece of silicon. It describes their working principles, device architectures, fabrication techniques and practical implementations, and highlights why 3D flash is a brand new technology.After reviewing market trends for both NAND and solid state drives (SSDs), the book digs into the details of the flash memory cell itself, covering both floating gate and emerging charge trap technologies. There is a plethora of different materials and vertical integration schemes out there. New memory cells, new materials, new architectures (3D Stacked, BiCS and P-BiCS, 3D FG, 3D VG, 3D advanced architectures); basically, each NAND manufacturer has its own solution. Chapter 3 to chapter 7 offer a broad overview of how 3D can materialize. The 3D wave is impacting emerging memories as well and chapter 8 covers 3D RRAM (resistive RAM) crosspoint arrays. Visualizing 3D structures can be a challenge for the human brain: this is way all these chapters contain a lot of bird's-eye views and cross sections along the 3 axes.The second part of the book is devoted to other important aspects, such as advanced packaging technology (i.e. TSV in chapter 9) and error correction codes, which have been leveraged to improve flash reliability for decades. Chapter 10 describes the evolution from legacy BCH to the most recent LDPC codes, while chapter 11 deals with some of the most recent advancements in the ECC field. Last but not least, chapter 12 looks at 3D flash memories from a system perspective. Is 14nm the last step for planar cells Can 100 layers be integrated within the same piece of silicon Is 4 bit/cell possible with 3D Will 3D be reliable enough for enterprise and datacenter applications These are some of the questions that this book helps answering by providing insights into 3D flash memory design, process technology and applications. 404 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -An Introduction that describes the origin of cytochrome notation also connects to the history of the field, focusing on research in England in the pre-World War II era. The start of the modern era of studies on structure-function of cytochromes and energy-transducing membrane proteins was marked by the 1988 Nobel Prize in Chemistry, given to J. Deisenhofer, H. Michel, and R. Huber for determination of the crystal structure of the bacterial photosynthetic reaction center. An ab initio logic of presentation in the book discusses the evolution of cytochromes and hemes, followed by theoretical perspectives on electron transfer in proteins and specifically in cytochromes. There is an extensive description of the molecular structures of cytochromes and cytochrome complexes from eukaryotic and prokaryotic sources, bacterial, plant and animal. The presentation of atomic structure information has a major role in these discussions, and makes an important contribution to the broad field of membrane protein structure-function. 788 pp. Englisch.