springer new york feb 2015 (111 risultati)

Taschenbuch. Condizione: Neu. Neuware -For over three decades, this best-selling classic has been used by thousands of students in the United States and abroad as a must-have textbook for a transitional course from calculus to analysis. It has proven to be very useful for mathematics majors who have no previous experience with rigorous proofs. Its friendly style unlocks the mystery of writing proofs, while carefully examining the theoretical basis for calculus. Proofs are given in full, and the large number of well-chosen examples and exercises range from routine to challenging.The second edition preserves the book¿s clear and concise style, illuminating discussions, and simple, well-motivated proofs. New topics include material on the irrationality of pi, the Baire category theorem, Newton's method and the secant method, and continuous nowhere-differentiable functions.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 424 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume is the most up-to-date text available on diffuse malignant mesothelioma and includes all the newest imaging modalities, immunohistochemical features, and ever-expanding information on the molecular characteristics of the cancer. In-depth chapters contain fully referenced text as well as detailed tables and images. While the primary audiences for this book are pathologists and pathology residents, the broad examination of diffuse malignant mesothelioma, including its epidemiology, makes this book valuable to radiologists, surgeons, oncologists, and other clinical physicians and their residents as well.Written by experts in the field, Diffuse Malignant Mesothelioma is a concise yet comprehensive resource for clinicians involved in the management of one of the most widely recognized and feared cancers in the world.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 156 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -In creating interpretive strategies for maritime sites, archaeologists and resource managers often are required to think creatively to overcome challenges and problems. These issues include interpreting sites in inaccessible locations and extremely deep water, enabling and controlling access to fragile sites and restricted areas, monitoring visitor behavior, making information interesting to a wide audience, and creating opportunities for public engagement, among other concerns. Meeting Challenges presents cutting-edge interpretation and public education strategies for maritime resources, both on land and underwater, with emphasis on solving the unique problems often associated with presenting these fragile, limited-access sites as heritage attractions and on developing effective visitation and civic engagement opportunities. The examples presented ideally can serve as models for resource managers, archaeologists engaged in interpretation, and site administrators. This volume brings together a diverse group of heritage professionals to discuss issues they¿ve encountered and to present ideas and case studies for adapting, improvising, and overcoming them.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 228 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book provides a theoretical background of branching processes and discusses their biological applications. Branching processes are a well-developed and powerful set of tools in the field of applied probability. The range of applications considered includes molecular biology, cellular biology, human evolution and medicine. The branching processes discussed include Galton-Watson, Markov, Bellman-Harris, Multitype, and General Processes. As an aid to understanding specific examples, two introductory chapters, and two glossaries are included that provide background material in mathematics and in biology. The book will be of interest to scientists who work in quantitative modeling of biological systems, particularly probabilists, mathematical biologists, biostatisticians, cell biologists, molecular biologists, and bioinformaticians. The authors are a mathematician and cell biologist who have collaborated for more than a decade in the field of branching processes in biology for this new edition.This second expanded edition adds new material published during the last decade, with nearly 200 new references. More material has been added on infinitely-dimensional multitype processes, including the infinitely-dimensional linear-fractional case. Hypergeometric function treatment of the special case of the Griffiths-Pakes infinite allele branching process has also been added. There are additional applications of recent molecular processes and connections with systems biology are explored, and a new chapter on genealogies of branching processes and their applications.Reviews of First Edition:'This is a significant book on applications of branching processes in biology, and it is highly recommended for those readers who are interested in the application and development of stochastic models, particularly those with interests in cellular and molecular biology.' (Siam Review, Vol. 45 (2), 2003)¿This book will be very interesting and usefulfor mathematicians, statisticians and biologists as well, and especially for researchers developing mathematical methods in biology, medicine and other natural sciences.¿ (Short Book Reviews of the ISI, Vol. 23 (2), 2003)Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 300 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Statistical Methods for Dynamic Treatment Regimes shares state of the art of statistical methods developed to address questions of estimation and inference for dynamic treatment regimes, a branch of personalized medicine. This volume demonstrates these methods with their conceptual underpinnings and illustration through analysis of real and simulated data. These methods are immediately applicable to the practice of personalized medicine, which is a medical paradigm that emphasizes the systematic use of individual patient information to optimize patient health care. This is the first single source to provide an overview of methodology and results gathered from journals, proceedings, and technical reports with the goal of orienting researchers to the field. The first chapter establishes context for the statistical reader in the landscape of personalized medicine. Readers need only have familiarity with elementary calculus, linear algebra, and basic large-sample theory to use this text. Throughout the text, authors direct readers to available code or packages in different statistical languages to facilitate implementation. In cases where code does not already exist, the authors provide analytic approaches in sufficient detail that any researcher with knowledge of statistical programming could implement the methods from scratch. This will be an important volume for a wide range of researchers, including statisticians, epidemiologists, medical researchers, and machine learning researchers interested in medical applications. Advanced graduate students in statistics and biostatistics will also find material in Statistical Methods for Dynamic Treatment Regimes to be a critical part of their studies.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 220 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book was written to provide resource materials for teachers to use in their introductory or intermediate statistics class. The chapter content is ordered along the lines of many popular statistics books so it should be easy to supplement the content and exercises with class lecture materials.The book contains R script programs to demonstrate important topics and concepts covered in a statistics course, including probability, random sampling, population distribution types, role of the Central Limit Theorem, creation of sampling distributions for statistics, and more. The chapters contain T/F quizzes to test basic knowledge of the topics covered. In addition, the book chapters contain numerous exercises with answers or solutions to the exercises provided. The chapter exercises reinforce an understanding of the statistical concepts presented in the chapters. An instructor can select any of the supplemental materials to enhance lectures and/or provide additional coverage of concepts and topics in their statistics book.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 308 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book is designed as an introductory course in Tropical Meteorology for the graduate or advanced level undergraduate student. The material within can be covered in a one-semester course program. The text starts from the global scale-view of the Tropics, addressing the zonally symmetric and asymmetric features of the tropical circulation. It then goes on to progressively smaller spatial and time scales ¿ from the El Niño Southern Oscillation and the Asian Monsoon, down to tropical waves, hurricanes, sea breezes, and tropical squall lines. The emphasis in most chapters is on the observational aspects of the phenomenon in question, the theories regarding its nature and maintenance, and the approaches to its numerical modeling. The concept of scale interactions is also presented as a way of gaining insight into the generation and redistribution of energy for the maintenance of oscillations of a variety of spatial and temporal scales.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 440 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -¿¿New data have come to light through the Solution Focused Brief Therapy Association Archive (hereafter, the Archive). This information is drawn from manuscripts and video featuring one of the SF founders, Insoo Kim Berg, MSW. Archive video examples of Ms. Berg conductingsupervision, therapy teams, and case consultation as well as unpublishedmanuscripts written by her provide unique opportunities to illustrate specific assumptions and techniques rarely seen before.The documents outline Ms. Berg¿s philosophy, assumptions, and techniquesto conduct supervision, and the videos offer in vivo examples of her supervision and team/case consultation style. Together, the Archive materials offer a rich resource for a book that both informs and illustrates SFS¿.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 376 pp. Englisch.

Buch. Condizione: Neu. Neuware -In this volume expert researchers in the field detail the operations of microchip capillary electrophoresis. Chapters focus on small molecule, biomolecule applications, various detection modes, and sample preparation approaches are described. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Microchip Capillary Electrophoresis Protocol aids scientists in continuing to study microchip capillary electrophoresis.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 212 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This thesis represents the first wide-field photometric and spectroscopic survey of star clusters in the nearby late-spiral galaxy M33. This system is the nearest example of a dwarf spiral galaxy, which may have a unique role in the process of galaxy formation and evolution. The cold dark matter paradigm of galaxy formation envisions large spiral galaxies, such as the Milky Way, being formed from the merger and accretion of many smaller dwarf galaxies. The role that dwarf spiral galaxies play in this process is largely unclear. One of the goals of this thesis is to use the star cluster population of M33 to study its formation and evolution from its early stages to the present. The thesis presents a new comprehensive catalog of M33 star clusters, which includes magnitudes, colors, structural parameters, and several preliminary velocity measurements. Based on an analysis of these data, the thesis concludes that, among other things, the evolution of M33 has likely been influenced by its nearby massive neighbor M31.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 148 pp. Englisch.

Buch. Condizione: Neu. Neuware -This second editionexplores membrane trafficking research that has been at the frontier of cell and molecular biology. In the past 20 years, this field has witnessed a remarkable convergence and synergism from information gained using genetic approaches in yeast cells, and biochemical and molecular approaches in mammalian cells. This volume contains updated chapters and the inclusion of a large number of new chapters, and is divided into three parts. Part I includes biochemical and molecular genetics approaches and methods used in analysing membrane traffic, in both yeast and mammalian cell models. Part II focuses on imaging and microscopy approaches and techniques, while Part III highlights the Omics-type approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and resourceful, Membrane Trafficking, Second Edition, is a valuable resource for both experienced researchers, graduate students, and junior scientists in the field of membrane trafficking.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 476 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume reviews the evolution of information regarding the epidemiology of DCIS and its modes of detection, as well as treatment options as a function of both clinical trial data and ongoing investigational therapeutic prospects. Several of the challenging and clinically-relevant scenarios of DCIS that appear in daily practice is discussed, including the difficulties of distinguishing ¿true¿ DCIS from borderline patterns of other breast diseases and the therapeutic implications of differentiating these various diagnoses. Particular attention is paid to pathologic evaluation of DCIS, including histologic patterns and the importance of margin evaluation/margin control. The text also explores the data regarding DCIS in medical research in hereditary susceptibility for breast cancer and race/ethnicity-associated disparities in breast cancer.Written by experts in the field, Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer is a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in breast cancer.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 184 pp. Englisch.

Buch. Condizione: Neu. Neuware -This comprehensive treatise on cutting edge tools and research provides a fascinating insight into the rapidly evolving field of diagnostic and therapeutic endoscopy. Accomplished international researchers and clinicians discuss the latest endoscopic advances in diverse areas including obesity and associated metabolic syndromes, management of peripancreatic fluid collections, endoluminal suturing techniques, fistula closure, management of Barrett¿s epithelium, cholangioscopy, chromoendoscopy, high resolution manometry and endoscopic ultrasonography.Gastrointestinal Endoscopy: New Technologies and Changing Paradigms is a valuable resource on the evolving role of endoscopic management of gastrointestinal diseases and is a tremendous resource for gastroenterologists, endoscopists, GI surgeons, and medical residents.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 232 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book provides a state-of-the-art review of the role of radiation therapy in various pelvic malignancies as well as the consequences of the radiation in the pelvic tissues. With sections covering the role of radiation therapy in the various pelvic malignancies, the pathophysiology of radiation related injury and the risk factors that increase the possibility of such an injury, and the latest in medical, endoscopic and surgical therapies for these radiation related complications the text offers a concise yet comprehensive overview of radiation therapy in the human pelvis, its role and the adverse effects on the pelvic organs. Written by experts in the field with readers in mind, Radiation Therapy for Pelvic Malignancy and its Consequences is the first of its kind standalone reference on the subject. Radiation Therapy for Pelvic Malignancy and its Consequences is of great value to urologists, medical radiation and gynecological oncologists, and gastroenterologists.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 244 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume is designed to be a resource of proven techniques and approaches for probing the activities of bacterial, eukaryotic, and archaeal RNA polymerases. This book features a collection of in vitro and in vivo technologies that will permit researchers to purify and probe the position and stability of RNA polymerase complexes at different points of the transcription cycle, analyze the various translocations and intermolecular movements associated with catalysis, define recruitment strategies, probe the roles of transcription factors in each stage of the cycle, highlight conserved and disparate fidelity mechanisms, analyze the resultant transcripts, and study coordination of the nascent mRNA synthesis by the RNA polymerase and mRNA translation by the ribosome. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubles troubleshooting and avoiding known pitfalls.Practical and timely, Bacterial Transcriptional Controls: Methods and Protocols highlights the breadth and depth of techniques that are likely to continue shaping the transcription community in the future.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 356 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume explores the technological improvements in protein engineering, expression, purification, and crystallization of several rhodopsin photoactive intermediates, thus increasing our understanding of rhodopsin activation. The first chapters of the book focus on methods developed to study fundamentals of rhodopsin structure and function, starting with improved purification protocols of native and mutated rhodopsin, followed by methods used for rhodopsin reconstitution into lipid bilayers stabilizing rhodopsin function properties, and finally describing recently developed methods to study structural dynamics of rhodopsin activation and its mechanistic properties. Subsequently, chapters underline various techniques that have been developed to visualize the rhodopsin dimer and to study its functional significance. The next few chapters highlight cutting-edge imaging techniques of photoreceptors, rhodopsin trafficking, and its diffusion within signaling membranes. Finally the book concludes with recent developments that could be potentially beneficial in patient treatments, and treatment strategies for retinal degenerative diseases. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.Timely and practical, Rhodopsin: Methods and Protocols reaches out to researchers and health practitioners, and provides timely protocol useful for studying structural and functional properties of rhodopsin.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 428 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book describes model-based development of adaptive embedded systems, which enable improved functionality using the same resources. The techniques presented facilitate design from a higher level of abstraction, focusing on the problem domain rather than on the solution domain, thereby increasing development efficiency. Models are used to capture system specifications and to implement (manually or automatically) system functionality. The authors demonstrate the real impact of adaptivity on engineering of embedded systems by providing several industrial examples of the models used in the development of adaptive embedded systems.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 320 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume presents a collection of protocols for immunocytochemical analysis of neurons and neural networks. Chapters focus on immunocytochemical localization at light and electronic levels, biochemical characterization, and functional analysis in vivo or ex vivo by novel types of microscopy, as well as protocols for development and production of genetic probes. Written for the popular Neuromethodsseries, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Essential and authoritative, Immunocytochemistry and Related Techniques is intended for a large audience of scientists, including histologists, biochemists, cellular and molecular biologists, electrophysiologists that are currently active in the field or are willing to enter the exciting area of neuroscience research.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 488 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume collects a series of protocols describing the kinds of infrastructures, training, and standard operating procedures currently available to actualize the potential of stem cells for regenerative therapies. Stem Cells and Good Manufacturing Practices: Methods, Protocols, and Regulations pulls together key GMP techniques from laboratories around the world. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Inclusive and authoritative, Stem Cells and Good Manufacturing Practices: Methods, Protocols, and Regulations will be an invaluable resource to both basic and clinical practitioners in stem cell biology.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 232 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume on metabonomics provides detailed information on the procedures involved in nuclear magnetic resonance (NMR) spectroscopy, gas chromatography-mass spectrometry (GS-MS), liquid chromatography-mass spectrometry (LC-MS), and capillary electrophoresis-mass spectrometry (CE-MS). Chapters focus on technologies and chemometrics, generation of metabonomics data, extraction of meaningful information from data, drug development, toxicology, diagnostics, and describing metabonomics as an essential part of systems biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 272 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume covers the techniques necessary for a successful fragment-based drug design project, beginning from defining the problem in terms of preparing the protein model, identifying potential binding sites, and the consideration of various candidate fragments for simulation. The second part discusses the technical aspects that various methods have used to simulate fragment binding to a target protein by using Monte Carlo, molecular dynamics, and docking algorithms. After simulations, fragments are assembled into molecules using a variety of approaches, which are explored next. A discussion of design strategies and consideration of drug-like properties is included as part of the design process at this stage. Finally, several examples of successful fragment-based drug design projects are presented. Written for the Methods in Molecular Biology series, this work contains the kind of detailed description and implementation advice to encourage success in the lab.Practical and cutting-edge, Fragment-Based Methodsin Drug Discovery takes into account the great accomplishments in the field to provide an ideal guide for researchers continuing to investigate this exciting area of pharmacological study.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 240 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -This book develops voltage-to-frequency converter (VFC) solutions integrated in standard CMOS technology to be used as a part of a microcontroller-based, multisensor interface in the environment of portable applications, particularly within a WSN node. Coverage includes the total design flow of monolithic VFCs, according to the target application, as well as the analysis, design and implementation of the main VFC blocks, revealing the main challenges and solutions encountered during the design of such high performance cells. Four complete VFCs, each temperature compensated, are fully designed and evaluated: a programmable VFC that includes an offset frequency and a sleep/mode enable terminal; a low power rail-to-rail VFC; and two rail-to-rail differential VFCs.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 160 pp. Englisch.

Buch. Condizione: Neu. Neuware -This book provides a comprehensive overview of key technologies being used to address challenges raised by continued device scaling and the extending gap between memory and central processing unit performance. Authors discuss in detail what are known commonly as ¿More than Moore¿ (MtM), technologies, which add value to devices by incorporating functionalities that do not necessarily scale according to ¿Moore's Law¿. Coverage focuses on three key technologies needed for efficient power management and cost per performance: novel memories, 3D integration and photonic on-chip interconnect.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 228 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -The current medical literature contains ample text addressing the topics of trauma and critical care. However, there are few texts existing that specifically address the common surgical problems encountered by practicing acute care surgeons. Common Problems in Acute Care Surgery provides a comprehensive, evidence-based review of the most common clinical problems encountered by acute care surgeons. Focusing on the clinical care of the patient, this volume explores the general principles of acute care surgery and the specific disease states that are commonly encountered by acute care surgeons. The work also touches upon the ethical issues and systems development behind acute care surgery, including practical considerations for establishing an acute care surgery program, ethical considerations in acute care surgery, and the role of palliative care.Authored by respected experts in the field and illustrated throughout with detailed photographs, Common Problems in Acute Care Surgery is of great value to resident surgeons in training, fellows, and practicing surgeons in acute care surgery.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 548 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume contains a comprehensive compilation of chromogenic and fluorescent RNA in situ hybridization (ISH) technology in many of its various shades, forms,and applications.The book is organized into a number of parts and chapters focusing on the application of ISH methodologies to different animal species as used in Evolutionary Development (EvoDevo) and Biomedical research, and covering new developments in RNA visualization by fluorescent ISH (FISH). The described (F)ISH protocols employ effective strategies for signal enhancement and target amplification allowing for high signal intensities and drastically improved signal-to-noise ratios. Chromogenic and fluorescent ISH, as specified in the various chapters, are most essential for RNA expression profiling, applied to many fields of research including cellular, developmental, and evolutionary biology, neurobiology and neuropathology. Written for the popular Neuromethodsseries, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Essential and authoritative, In Situ Hybridization Methodsprovides detailed protocols for newcomers to ISH,and inspires researchers familiar with the technique to seek and find up-to-date methodology for new and specialized applications.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 612 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -As globalization causes profound changes in business, industry, and trade,it can also have significant effects on populations, environments, and individuals.These effectsmay beharmful, resulting in injury or illness, prompting the critical question: How best to correct wrongs caused to individuals, communities, and/or the environment of one country by the actions of individuals or corporations of another Possibleanswers lie in an emerging discipline. Forensic Epidemiology in the Global Context opens meaningful windows onto the processes of forensic epidemiology, the roles of the epidemiologist in civil disputes, and the potential contribution of the field to legal and justice efforts worldwide. Case examples from the U.K., Nigeria, Ecuador, Romania, and Australia illustrate commonly used methodologies and the challenges involved in their use in U.S. and international courts of law.Achapter on expert testimony takes readers through qualification and admissibility issues, report requirements, and working with attorneys. Included in the coverage:Forensic epidemiology in the international legal arena.The epidemiologist as an expert in litigation.Epidemiological evidence in tort law: dispatches from the U.K.Liability for occupational exposure: the role of epidemiology.Forensic epidemiology and environmental justice.Forensic epidemiology, pathology, ethnics, and human rights.By emphasizing both the scientific and legalcomponentsof the equation, Forensic Epidemiology in the Global Context gives researchers and graduate students in epidemiology a unique and timely guide to the present and future of an increasingly salient field.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 168 pp. Englisch.

Buch. Condizione: Neu. Neuware -Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria.Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 560 pp. Englisch.

Buch. Condizione: Neu. Neuware -This volume provides an overview on design PCR primers for successful DNA amplification. Chapters focus on primer design strategies for quantitative PCR, in silico PCR primer design, and primer design using software. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, PCR Primer Design, Second Edition seeks to aid molecular biology students, researchers, professors and PCR enthusiasts.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 228 pp. Englisch.

Buch. Condizione: Neu. Neuware -Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including determination of risk in longitudinal studies, assessment of therapy in randomized controlled clinical trials, and evaluation of diagnostic tests, and then delves into the more specialized area of clinical genetic research, before concluding with basic methods used in evidence-based decision making including critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and practical advice to ensure real world success.Comprehensive and authoritative, Clinical Epidemiology: Practice and Methods, Second Edition is intended to educate researchers on how to undertake clinical research and should be helpful not only to medical practitioners but also to basic scientists who want to extend their work to humans, to allied health professionals interested in scientific evaluation, and to trainees in clinical epidemiology.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 548 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since 1978, the opening up and reform in China has brought tremendous economic and social changes. While China's economic progress has been commendable, the social problems that go with economic changes have raised serious concerns. Some of those concerns are related to gender, ethnic, labor, and environmental issues. This book is about what has happened in these arenas in China since the opening up and reform in 1978. The study of gender, ethnicity, labor, and environment touches on some of the fundamental problems of modernization, especially the development of individuals and groups. So even though gender, ethnicity, labor, and environment seem to be separate issues, they are in fact related in some fundamental ways. That's what this book will explore as well. To understand is one thing and to do is another. This book also incorporates studies of NGO practices to see how NGOs have helped in transforming gender, ethnic, labor, and environment interplay. Our study of NGOs in helping improve such interplay sheds light on how specifically civil society can prod the state to transform social relations for the better. This book is an attempt to assess the changes, both positive and negative, in gender, ethnic, ethnic, and environmental relations in China especially in the past 30 years of opening up and reform, especially regarding national identity formation. 344 pp. Englisch.