springer us okt 1989 (19 risultati)

Buch. Condizione: Neu. Neuware -The Statistical Analysis of Discrete Data provides an introduction to cur rent statistical methods for analyzing discrete response data. The book can be used as a course text for graduate students and as a reference for researchers who analyze discrete data. The book's mathematical prereq uisites are linear algebra and elementary advanced calculus. It assumes a basic statistics course which includes some decision theory, and knowledge of classical linear model theory for continuous response data. Problems are provided at the end of each chapter to give the reader an opportunity to ap ply the methods in the text, to explore extensions of the material covered, and to analyze data with discrete responses. In the text examples, and in the problems, we have sought to include interesting data sets from a wide variety of fields including political science, medicine, nuclear engineering, sociology, ecology, cancer research, library science, and biology. Although there are several texts available on discrete data analysis, we felt there was a need for a book which incorporated some of the myriad recent research advances. Our motivation was to introduce the subject by emphasizing its ties to the well-known theories of linear models, experi mental design, and regression diagnostics, as well as to describe alterna tive methodologies (Bayesian, smoothing, etc. ); the latter are based on the premise that external information is available. These overriding goals, to gether with our own experiences and biases, have governed our choice of topics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 388 pp. Englisch.

Buch. Condizione: Neu. Neuware -Source coding theory has as its goal the characterization of the optimal performance achievable in idealized communication systems which must code an information source for transmission over a digital communication or storage channel for transmission to a user. The user must decode the information into a form that is a good approximation to the original. A code is optimal within some class if it achieves the best possible fidelity given whatever constraints are imposed on the code by the available channel. In theory, the primary constraint imposed on a code by the channel is its rate or resolution, the number of bits per second or per input symbol that it can transmit from sender to receiver. In the real world, complexity may be as important as rate. The origins and the basic form of much of the theory date from Shan non's classical development of noiseless source coding and source coding subject to a fidelity criterion (also called rate-distortion theory) [73] [74]. Shannon combined a probabilistic notion of information with limit theo rems from ergodic theory and a random coding technique to describe the optimal performance of systems with a constrained rate but with uncon strained complexity and delay. An alternative approach called asymptotic or high rate quantization theory based on different techniques and approx imations was introduced by Bennett at approximately the same time [4]. This approach constrained the delay but allowed the rate to grow large.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 206 pp. Englisch.

Buch. Condizione: Neu. Neuware -The first Stanford MIPS project started as a special graduate course in 1981. That project produced working silicon in 1983 and a prototype for running small programs in early 1984. After that, we declared it a success and decided to move on to the next project-MIPS-X. This book is the final and complete word on MIPS-X. The initial design of MIPS-X was formulated in 1984 beginning in the Spring. At that time, we were unsure that RISe technology was going to have the industrial impact that we felt it should. We also knew of a number of architectural and implementation flaws in the Stanford MIPS machine. We believed that a new processor could achieve a performance level of over 10 times a VAX 11/780, and that a microprocessor of this performance level would convince academic skeptics of the value of the RISe approach. We were concerned that the flaws in the original RISe design might overshadow the core ideas, or that attempts to industrialize the technology would repeat the mistakes of the first generation designs. MIPS-X was targeted to eliminate the flaws in the first generation de signs and to boost the performance level by over a factor of five.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 260 pp. Englisch.

Buch. Condizione: Neu. Neuware -Recently there has been increased interest in the development of computer-aided design programs to support the system level designer of integrated circuits more actively. Such design tools hold the promise of raising the level of abstraction at which an integrated circuit is designed, thus releasing the current designers from many of the details of logic and circuit level design. The promise further suggests that a whole new group of designers in neighboring engineering and science disciplines, with far less understanding of integrated circuit design, will also be able to increase their productivity and the functionality of the systems they design. This promise has been made repeatedly as each new higher level of computer-aided design tool is introduced and has repeatedly fallen short of fulfillment. This book presents the results of research aimed at introducing yet higher levels of design tools that will inch the integrated circuit design community closer to the fulfillment of that promise. 1. 1. SYNTHESIS OF INTEGRATED CmCUITS In the integrated circuit (Ie) design process, a behavior that meets certain specifications is conceived for a system, the behavior is used to produce a design in terms of a set of structural logic elements, and these logic elements are mapped onto physical units. The design process is impacted by a set of constraints as well as technological information (i. e. the logic elements and physical units used for the design).Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 324 pp. Englisch.

Buch. Condizione: Neu. Neuware -Fish lymphocystis disease virus (FLDV) has been tentatively classified as a separate genus of the iridovirus family. Iridoviruses were previously called icosahedral cytoplasmic deoxyriboviruses (ICDV). The Iridoviridae family contains four genera including lymphocystis disease virus (proposed name Lymphocystivirus, Willis, 1989 (1». FLDV is a causative agent of lymphocystis disease (LD) which frequently appears in Pleuronectidae (flatfish) such as Pleuronectes platessa (plaice), Platichtys flesus (flounder), Limanda limanda (dab), and Trigla gurnardus (gurnard). Fish lymphocystis disease is characterized by papilloma-like lesions, which can be induced experimentally in Lepomis macrochirus (bluegill) (2) and by subdermal injection of plaice and flounder (3). The mechanisms of this nonmalignant tumor induction are unknown. Since the discovery of LD in 1874 by Lowe (4), attempts have been made to isolate and propagate FLDV in vitro with limited success (5-7). As a first step towards understanding of the underlying mechanisms of this infectious disease the structure and properties of the causal virus must be eluciated. These basical molecular biological studies provide new facilities for investigation of virus host interactions which is necessary for understanding the molecular mechanisms of the viral pathogenesis. MATERIALS AND METHODS A total of 30 fish with LD lesions caught near the Doggerbank areas were analyzed individually, including 20 flounders, six dabs, and four plaice. Virions of FLDV from LD lesions of each species of fish were isolated, purified, and examined by electron microscopy as 205 described previously (8). Fig.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 324 pp. Englisch.

Buch. Condizione: Neu. Neuware - In breast cancer as in other cancers on the front line of modern interdisciplinary research we have crossed the threshhold of new understanding. Fueled by an awareness that breast cancer is a leading cause of morbidity and mortality in women and honed by rapid technological advances in molecular mechanisms, major inroads into the darkness of this scourge have been accomplished during the past several years. Basic laboratory and clinical research findings must influence and in turn be influenced by efforts to detect, to diagnose and to cure the human disease. It is indeed gratifying to note that the efforts of scientists and clinicians from throughout the world reported in this volume are achieving this objective. The first section of the book focuses on the molecular and genetic basis of breast cancer. The role of specific oncogenes in mammary tumorigenesis using transgenic mice and mammary glands correlating molecular events with specific stages in neoplastic development are described and discussed. Such topics as the nature of specific oncogenes, levels of oncogene expression, the alteration of expression of other growth regulatory genes and the state of the cell in which the oncogene is expressed are specifically addressed. This section of the book is rounded out with discussions on the potential of genetic alterations as indicators of prognosis, the characterization of full-length cDNA codes for breast cancer markers and the function of antigens in tuomorigenesis.

Buch. Condizione: Neu. Neuware - G. Petursson and Rikke Hoff-J0rgensen The concept of slow viral infections was first put forward in 1954 by Dr. Bjorn Sigurdsson, an Icelandic physician who had been studying some sheep diseases which were introduced into Iceland with the importation of a foreign breed of sheep in 1933. Sigurdsson's main criteria for defining slow infec tions were a very long initial period without clinical signs lasting months or even years following infection and a rather regular protracted, progres sive course, once clinical symptoms had appeared, usually ending in serious disease or death. Sigurdsson included in this list of slow infections maedi -visna, infectious adenomatosis of sheep, scrapie in sheep, Bittner's mam mary carcinoma and Gross' leukemia in mice. All of these diseases, except scrapie, are caused by retroviruses. The characteristics of slow infections as described above are of prac tical importance for epidemiology, diagnosis and control of these diseases. For many years the slow infections remained primarily a veterinary problem, mainly affecting sheep and goats in certain countries. In recent years, how ever, the human immunodeficiency virus (HIV) causing acquired immunodefici ency syndrome (AIDS), has suddenly appeared in many countries of the world and brought the slow infection concept forcefully to the attention of the medical profession. The disease problems and the economic effects of slow infections of sheep and goats are increasingly recognized in various coun tries. For the reasons stated above we feel that this book should be useful for veterinarians and physicians alike.

Buch. Condizione: Neu. Neuware - The prediction of the conformation of proteins has developed from an intellectual exercise into a serious practical endeavor that has great promise to yield new stable enzymes, products of pharmacological significance, and catalysts of great potential. With the application of predic tion gaining momentum in various fields, such as enzymology and immunology, it was deemed time that a volume be published to make available a thorough evaluation of present methods, for researchers in this field to expound fully the virtues of various algorithms, to open the field to a wider audience, and to offer the scientific public an opportunity to examine carefully its successes and failures. In this manner the practitioners of the art could better evaluate the tools and the output so that their expectations and applications could be more realistic. The editor has assembled chapters by many of the main contributors to this area and simultaneously placed their programs at three national resources so that they are readily available to those who wish to apply them to their personal interests. These algorithms, written by their originators, when utilized on pes or larger computers, can instantaneously take a primary amino acid sequence and produce a two-or three-dimensional artistic image that gives satisfaction to one's esthetic sensibilities and food for thought concerning the structure and function of proteins. It is in this spirit that this volume was envisaged.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Source coding theory has as its goal the characterization of the optimal performance achievable in idealized communication systems which must code an information source for transmission over a digital communication or storage channel for transmission to a user. The user must decode the information into a form that is a good approximation to the original. A code is optimal within some class if it achieves the best possible fidelity given whatever constraints are imposed on the code by the available channel. In theory, the primary constraint imposed on a code by the channel is its rate or resolution, the number of bits per second or per input symbol that it can transmit from sender to receiver. In the real world, complexity may be as important as rate. The origins and the basic form of much of the theory date from Shan non's classical development of noiseless source coding and source coding subject to a fidelity criterion (also called rate-distortion theory) [73] [74]. Shannon combined a probabilistic notion of information with limit theo rems from ergodic theory and a random coding technique to describe the optimal performance of systems with a constrained rate but with uncon strained complexity and delay. An alternative approach called asymptotic or high rate quantization theory based on different techniques and approx imations was introduced by Bennett at approximately the same time [4]. This approach constrained the delay but allowed the rate to grow large. 206 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -There has been an enormous growth in recent years in the literature on discrete optimal designs. The optimality problems have been formulated in various models arising in the experimental designs and substantial progress has been made towards solving some of these. The subject has now reached a stage of completeness which calls for a self-contained monograph on this topic. The aim of this monograph is to present the state of the art and to focus on more recent advances in this rapidly developing area. We start with a discussion of statistical optimality criteria in Chapter One. Chapters Two and Three deal with optimal block designs. Row-column designs are dealt with in Chapter Four. In Chapter Five we deal with optimal designs with mixed effects models. Repeated measurement designs are considered in Chapter Six. Chapter Seven deals with some special situations and Weighing designs are dis cussed in Chapter Eight. We have endeavoured to include all the major developments that have taken place in the last three decades. The book should be of use to research workers in several areas including combinatorics as well as to the experimenters in diverse fields of applications. Since the details of the construction of the designs are available in excellent books, we have only pointed out the designs which have optimality proper ties. We believe, this will be adequate for the experimenters.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 180 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In early 1986, one of us (D.M.S.) was constructing an artificial intelligence system to design algorithms, and the other (A.P.A.) was getting started in program transformations research. We shared an office, and exchanged a few papers on the systematic development of algorithms from specifications. Gradually we realized that we were trying to solve some of the same problems. And so, despite radical differences between ourselves in research approaches, we set out together to see what we could learn from these papers. That's how this book started: a couple of graduate students trying to cope with The Literature. At first, there was just a list of papers. One of us (D.M.S.) tried to cast the papers in a uniform framework by describing the problem spaces searched, an approach used in artificial intelligence for understanding many tasks. The generalized problem space descriptions, though useful, seemed to abstract too much, so we decided to compare papers by different authors dealing with the same algorithm. These comparisons proved crucial: for then we began to see similar key design choices for each algorithm.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 132 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Many of the diseases which afflict people in an affluent society like the United States seem to be related to food consumption (e.g., adult-onset diabetes mellitus, hyperlipidemia, and colon cancer). In recent years, the health-related professions have become aware that their exclusive aim of disease treatment must be expanded to include health promotion. Professionals in food and nutrition, health education, social marketing, and psychology, as well as others have become interested in finding ways to promote healthy behaviors such as appropriate food consumption patterns. To modify food-related behavior, knowledge about why people eat what they eat is required. Both biological and sociocultural factors determine people's consumption behavior. This monograph, however, examines only the sociocultural determinants of individuals' food-related behaviors within their zone of biological indifference. The sociocultural variables are divided into two major categories - sociodemographic and psychological. Sociodemographic variables are often called external variables and include income, ethnicity, age, and the like. Psychosocial variables are thought to reflect the individual's internal state, and commonly examined variables include knowledge, beliefs, and attitudes.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 200 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Recently there has been increased interest in the development of computer-aided design programs to support the system level designer of integrated circuits more actively. Such design tools hold the promise of raising the level of abstraction at which an integrated circuit is designed, thus releasing the current designers from many of the details of logic and circuit level design. The promise further suggests that a whole new group of designers in neighboring engineering and science disciplines, with far less understanding of integrated circuit design, will also be able to increase their productivity and the functionality of the systems they design. This promise has been made repeatedly as each new higher level of computer-aided design tool is introduced and has repeatedly fallen short of fulfillment. This book presents the results of research aimed at introducing yet higher levels of design tools that will inch the integrated circuit design community closer to the fulfillment of that promise. 1. 1. SYNTHESIS OF INTEGRATED CmCUITS In the integrated circuit (Ie) design process, a behavior that meets certain specifications is conceived for a system, the behavior is used to produce a design in terms of a set of structural logic elements, and these logic elements are mapped onto physical units. The design process is impacted by a set of constraints as well as technological information (i. e. the logic elements and physical units used for the design). 324 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The first Stanford MIPS project started as a special graduate course in 1981. That project produced working silicon in 1983 and a prototype for running small programs in early 1984. After that, we declared it a success and decided to move on to the next project-MIPS-X. This book is the final and complete word on MIPS-X. The initial design of MIPS-X was formulated in 1984 beginning in the Spring. At that time, we were unsure that RISe technology was going to have the industrial impact that we felt it should. We also knew of a number of architectural and implementation flaws in the Stanford MIPS machine. We believed that a new processor could achieve a performance level of over 10 times a VAX 11/780, and that a microprocessor of this performance level would convince academic skeptics of the value of the RISe approach. We were concerned that the flaws in the original RISe design might overshadow the core ideas, or that attempts to industrialize the technology would repeat the mistakes of the first generation designs. MIPS-X was targeted to eliminate the flaws in the first generation de signs and to boost the performance level by over a factor of five. 260 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -No other area of biology has grown as fast and become as relevant over the last decade as virology. It is with no little amount of amaze ment, that the more we learn about fundamental biological questions and mechanisms of diseases, the more obvious it becomes that viruses perme ate all facets of our lives. While on one hand viruses are known to cause acute and chronic, mild and fatal, focal and generalized diseases, on the other hand, they are used as tools for gaining an understanding of the structure and function of higher organisms, and as vehicles for carrying protective or curative therapies. The wide scope of approaches to different biological and medical virological questions was well rep resented by the speakers that participated in this year's Symposium. While the epidemic by the human immunodeficiency virus type 1 continues to spread without hope for much relief in sight, intriguing questions and answers in the area of diagnostics, clinical manifestations and therapeutical approaches to viral infections are unveiled daily. Let us hope, that with the increasing awareness by our society of the role played by viruses, not only as causative agents of diseases, but also as models for better understanding basic biological principles, more efforts and resources are placed into their study. Luis M. de la Maza Irvine, California Ellena M.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 348 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -No other area of biology has grown as fast and become as relevant over the last decade as virology. It is with no little amount of amaze ment, that the more we learn about fundamental biological questions and mechanisms of diseases, the more obvious it becomes that viruses perme ate all facets of our lives. While on one hand viruses are known to cause acute and chronic, mild and fatal, focal and generalized diseases, on the other hand, they are used as tools for gaining an understanding of the structure and function of higher organisms, and as vehicles for carrying protective or curative therapies. The wide scope of approaches to different biological and medical virological questions was well rep resented by the speakers that participated in this year's Symposium. While the epidemic by the human immunodeficiency virus type 1 continues to spread without hope for much relief in sight, intriguing questions and answers in the area of diagnostics, clinical manifestations and therapeutical approaches to viral infections are unveiled daily. Let us hope, that with the increasing awareness by our society of the role played by viruses, not only as causative agents of diseases, but also as models for better understanding basic biological principles, more efforts and resources are placed into their study. Luis M. de la Maza Irvine, California Ellena M. 348 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Fish lymphocystis disease virus (FLDV) has been tentatively classified as a separate genus of the iridovirus family. Iridoviruses were previously called icosahedral cytoplasmic deoxyriboviruses (ICDV). The Iridoviridae family contains four genera including lymphocystis disease virus (proposed name Lymphocystivirus, Willis, 1989 (1'. FLDV is a causative agent of lymphocystis disease (LD) which frequently appears in Pleuronectidae (flatfish) such as Pleuronectes platessa (plaice), Platichtys flesus (flounder), Limanda limanda (dab), and Trigla gurnardus (gurnard). Fish lymphocystis disease is characterized by papilloma-like lesions, which can be induced experimentally in Lepomis macrochirus (bluegill) (2) and by subdermal injection of plaice and flounder (3). The mechanisms of this nonmalignant tumor induction are unknown. Since the discovery of LD in 1874 by Lowe (4), attempts have been made to isolate and propagate FLDV in vitro with limited success (5-7). As a first step towards understanding of the underlying mechanisms of this infectious disease the structure and properties of the causal virus must be eluciated. These basical molecular biological studies provide new facilities for investigation of virus host interactions which is necessary for understanding the molecular mechanisms of the viral pathogenesis. MATERIALS AND METHODS A total of 30 fish with LD lesions caught near the Doggerbank areas were analyzed individually, including 20 flounders, six dabs, and four plaice. Virions of FLDV from LD lesions of each species of fish were isolated, purified, and examined by electron microscopy as 205 described previously (8). Fig. 324 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume comprises the proceedings of the sixth in a series of International Symposia devoted to basic and clinical aspects of urolithiasis. Previous symposia have been held at intervals of four years in Leeds, Madrid, Davos, Williamsburg, and Garmisch-Partenkirchen. The sixth symposium was held in Vancouver, British Columbia and was attended by over 250 participants from 26 countries around the world. As may be seen from the contents of this volume, the meeting covered many aspects of urolithiasis including the underlying physiology, crystal formation and the effects of inhibitors and promoters on crystallization, endocrinology and abnormalities of urinary composition, analyses, geography and epidemiology, and medical and surgical treatment with a special emphasis on extracorporeal lithotripsy. Internationally-recognized authorities gave invited talks in each of these areas, and from the submitted abstracts 30 were selected for oral presentation and the remainder were presented in either general or theme poster sessions. The nine theme-poster sessions provided a particularly valuable and successful feature of the meeting, giving an opportunity for a group of researchers working in related areas to present their posters and also to give a brief oral summary which was followed by discussion with the audience. Each of these poster sessions was chaired by two experts in the field who have provided an overview of each theme-poster session for this volume. 1108 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This volume comprises the proceedings of the sixth in a series of International Symposia devoted to basic and clinical aspects of urolithiasis. Previous symposia have been held at intervals of four years in Leeds, Madrid, Davos, Williamsburg, and Garmisch-Partenkirchen. The sixth symposium was held in Vancouver, British Columbia and was attended by over 250 participants from 26 countries around the world. As may be seen from the contents of this volume, the meeting covered many aspects of urolithiasis including the underlying physiology, crystal formation and the effects of inhibitors and promoters on crystallization, endocrinology and abnormalities of urinary composition, analyses, geography and epidemiology, and medical and surgical treatment with a special emphasis on extracorporeal lithotripsy. Internationally-recognized authorities gave invited talks in each of these areas, and from the submitted abstracts 30 were selected for oral presentation and the remainder were presented in either general or theme poster sessions. The nine theme-poster sessions provided a particularly valuable and successful feature of the meeting, giving an opportunity for a group of researchers working in related areas to present their posters and also to give a brief oral summary which was followed by discussion with the audience. Each of these poster sessions was chaired by two experts in the field who have provided an overview of each theme-poster session for this volume. 1108 pp. Englisch.