Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease: 65 - Rilegato

Rilegato

ISBN 10: 9400754159 ISBN 13: 9789400754157

Casa editrice: Springer Nature, 2012

Riassunto

This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.

Su questo libro

Contenuti:

I. Introduction

1. Introduction and Technical Survey; J. Robin Harris and Nathaniel G. Milton

II. Basic Science

2. Fibril Formation by Short Synthetic Peptides; Andrew Smith

3. In vitro Oligomerization and Fibrillogenesis of Amyloid-beta Peptides; Núria  Benseny-Cases, Oksana Klementieva and Josep Cladera

4. Tau Fibrillogenesis; Nitin Chaudhary and Ramakrishnan Nagaraj

5. Prion protein Aggregation and Fibrillogenesis In vitro; Jan Stöhr

6. α-Synuclein Aggregation and Modulating Factors; Katerina E. Paleologou and Omar M. A. El-Agnaf

7. Pathological Self-aggregation of β2-microglobulin: A Challenge for Protein Biophysics; Gennaro Esposito, Alessandra Corazza, and Vittorio Bellotti

8. Islet amyloid polypeptide – Aggregation and fibrillogenesis in vitro and its Inhibition; Janine Seeliger and Roland Winter

9. Mechanisms of Transthyretin Aggregation and Toxicity; Robert J. Gasperini, David W. Klaver, Xu Hou, Marie-Isabel Aguilar and David H. Small

10. Fibrillogenesis of Huntingtin and Other Glutamine Containing Proteins; Yuri L. Lyubchenko, Alexey V. Krasnoslobodtsev and Sorin Luca

11. Aggregation and Fibrillogenesis of Proteins not Associated with Disease – A few Case Studies; Moritz Lassé, Juliet A. Gerrard and  F. Grant Pearce

12. Experimental Inhibition of Peptide Fibrillogenesis by Synthetic Peptides, Carbohydrates and Drugs; Alagiri Srinivasan

13. Experimental inhibition of fibrillogenesis and neurotoxicity by amyloid-beta (Aβ) and other disease-related peptides/proteins by plant extracts and herbal compounds; Suresh Kumar, Edward  Okello and J. Robin Harris

III. Clinical Science: The Cerebral and Systemic Amyloid Diseases

Pathogenesis and therapeutic consideration of the major disorders

14. Alzheimer’s  Disease; Vanessa J. De-Paula, Marcia Radanovic, Breno S. Diniz, Orestes V. Forlenza

15. Modeling the Polyglutamine Aggregation Pathway in Huntington’s Disease: from Basic Studies to Clinical Applications;
 Keizo Sugaya

16. Parkinson’s Disease; Timothy R. Mhyre, James T. Boyd, Robert W.  Hamill, and Kathleen Maguire-Zeiss

17. Human Prion Diseases: From Kuru to Variant Creutzfeldt-Jakob Diseasae; Beata Sikorska and Paweł P. Liberski

18. Animal Prion Diseases; Otto Windl and Mike Dawson

19. β2-microglobulin Amyloidosis; Dorthe B. Corlin and Niels H.H. Heegaard

20. Systemic AA Amyloidosis; Jennifer H Pinney and Helen J Lachmann

21. Familial Amyloidotic Polyneuropathy and Transthyretin; Takamura Nagasaka 22. The Challenge of Systemic Immunoglobulin Light-chain Amyloidosis (AL); Giovanni Palladini and Raymond L Comenzo

Dalla quarta di copertina:

This volume of the Subcellular Biochemistry series is devoted to the aggregation and fibrillogenesis of the amyloid-forming peptides and proteins, including emphasis on oligomer formation as well as fibril formation. The diverse topics included here are presented within 22 chapters, covering many of the relevant topics from both a basic science and clinical perspective. The authorship of these chapters is thoroughly international, with authoritative contributions from active researchers. Fundamental structural and cellular studies using many different technical approaches are presented, leading through to clinical and therapeutic aspects of the amyloid diseases, considered from both pharmaceutical and natural product view points. It is hoped that this book will be of use to both biomedical scientists and clinicians wishing to keep abreast of this rapidly advancing field, of direct importance to the understanding of cerebral neurodegenerative disease and systemic amyloid disease.

Su questa edizione

• Editore: Springer Nature
• Data di pubblicazione: 2012
• ISBN 10: 9400754159
• ISBN 13: 9789400754157
• Rilegatura: Copertina rigida
• Numero di pagine: 648
• Redattore: Harris J. Robin