Practical Process Research and Development

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9780120594757: Practical Process Research and Development

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students.

  • Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules"
  • Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more
  • Includes over 100 tips for rapid process development
  • Presents guidelines for implementing and troubleshooting processes

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Book Description:

Foreword by K. Barry Sharpless, The Scripps Research Institute, La Jolla, CA and Dr. Jerome Moniot, Bristol-Myers Squibb

From the Back Cover:

Bringing a compound to market quickly and profitably requires efficient and
cost-effective processes for preparing large amounts of the target compound
and intermediates. The key to rapid and successful process development is avoiding scale-up problems. However, an understanding of scale-up issues is rarely
taught in academia and may take years of industrial experience to acquire.

Practical Process Research & Development teaches how to anticipate and
avoid these problems when processes are being scaled up from the research lab or
pilot plant. The approach is pragmatic, with a minimum of theory and over
100 practical scale-up tips. Many tables and detailed reaction schemes
allow the reader to identify critical processing steps quickly. This
practical guide is essential reading for chemists and chemical engineers
involved in industrial process research and/or process development and for
anyone seeking a clearer understanding of how and why process R&D is conducted in the pharmaceutical and fine chemicals industries.

KEY FEATURES

· Provides insights into generating rugged, practical, cost-effective
processes for the chemical preparation of "small molecules"
· Breaks down process optimization into route, reagent, and solvent
selection, development of reaction conditions, workup, crystallizations, and more
· Describes how to anticipate and avoid difficulties in scaling up reactions
· Discusses guidelines for the timely development of processes
· Illuminates principles with examples from the recent literature
· Includes over 100 tips for rapid process development
· Presents guidelines for implementing and troubleshooting processes
· Written by an author with over 22 years experience in process R&D in
the pharmaceutical industry

"... A must reference on every process chemists (both the novice and the experienced practitioner) desk. This will be required reading by all new chemists, engineers and analysts in my department."
--Sean T. Nugent, Searle Research & Development

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Anderson, Neal G.
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ISBN 10: 0120594757 ISBN 13: 9780120594757
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Descrizione libro Academic Press. Hardcover. Condizione libro: New. 0120594757 New Condition. Codice libro della libreria NEW6.0039734

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Descrizione libro Academic Press, 2017. Hardcover. Condizione libro: New. This item is printed on demand. Codice libro della libreria P110120594757

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Descrizione libro Elsevier Science Publishing Co Inc, United States, 2000. Hardback. Condizione libro: New. Language: English . Brand New Book. This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process RD describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process RD. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and green chemistry. Practical Process Research and Development will be a valuable resource for researchers, managers, and graduate students. Codice libro della libreria AA59780120594757

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Neal G. Anderson
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Descrizione libro Elsevier Science Publishing Co Inc, United States, 2000. Hardback. Condizione libro: New. Language: English . Brand New Book. This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process RD describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process RD. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and green chemistry. Practical Process Research and Development will be a valuable resource for researchers, managers, and graduate students. Codice libro della libreria AA59780120594757

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Descrizione libro Academic Pr, 2000. Hardcover. Condizione libro: Brand New. 1st edition. 354 pages. 9.25x6.25x0.75 inches. In Stock. Codice libro della libreria __0120594757

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Descrizione libro Academic Press, 2016. Paperback. Condizione libro: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Codice libro della libreria ria9780120594757_lsuk

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Descrizione libro Academic Press, 2000. Hardcover. Condizione libro: New. 1. Codice libro della libreria DADAX0120594757

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