General Chemistry Principles and Modern Applications 10th Ed. + Study Card 10th Ed. + Masteringchemistry Student Access Kit - Rilegato

Petrucci, Ralph H.; Herring, F. Geoffrey; Madura, Jeffry D.; Bissonnette, Carey

Rilegato

ISBN 10: 0136121497 ISBN 13: 9780136121497

Casa editrice: Pearson College Div, 2010

Riassunto

The Molecule on the Front Cover is Paclitaxel, C47H51NO14 a chemotherapy drug that has been successful in treating breast, lung, and ovatian cancer. It is extracted from the bark of the Pacific Yew tree (Taxus brevifolia). Unfortunately, the bark of a 100-year-old Pacific Yew tree yields about 3 kg of bark and only 300 mg of paclitaxel, barely enough for a single dose of the drug (Taxol).

The synthesis of this molecule engaged the attention of chemists for more than 20 years until finally, in 1994, chemists from Florida State University and from the University of California (San Diego) announced independently that they were able to synthesize it from simpler and readily available starting materials. A major challenge in the synthesis of paclitaxel is getting the spatial arrangement of atoms around 11 of the carbon atoms just right. These 11 carbon atoms are identified in the ball-and-stick structure by green or purple circles. If the synthesis is not done carefully, up to 2048 different possible paclitaxel-like structures could be obtained, but only one is known to have the desired anti-tumor activity. Because chemists can now synthesize paclitaxel, it is possible for researchers to explore how it works and design new chemotherapeutic drugs that are safer and more effective.

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Informazioni sull?autore

Ralph H. Petrucci

Ralph Petrucci received his B.S. in Chemistry from Union College, Schenectady, NY, and his Ph.D. from the University of Wisconsin—Madison. Following ten years of teaching, research, consulting, and directing the NSF Institutes for Secondary School Science Teachers at Case Western Reserve University, Cleveland, OH, Dr. Petrucci joined the planning staff of the new California State University campus at San Bernardino in 1964. There, in addition to his faculty appointment, he served as Chairman of the Natural Sciences Division and Dean of Academic Planning before retiring from teaching.

F. Geoffrey Herring

Geoff Herring received his B.Sc. and his Ph.D. in Physical Chemistry, both from the University of London. He is currently a Professor in the Department of Chemistry of the University of British Columbia, Vancouver. Dr. Herring has research interests in the area of biophysical chemistry and has published over 100 papers in the area of physical chemistry and chemical physics. Recently, Dr. Herring has undertaken studies in the use of information technology and interactive engagement methods in teaching general chemistry with a view to improving student comprehension and learning. Dr. Herring has taught chemistry from undergraduate to graduate levels for 30 years and has twice been the recipient of the Killam Prize for Excellence in Teaching.

Jeffry D. Madura

Jeffry D. Madura received his B.A. from Thiel College and his Ph.D. in Physical Chemistry from Purdue University. He is currently Professor and Chair in the Department of Chemistry and Biochemistry of Duquesne University in Pittsburgh, PA. Dr. Madura’s research interests are in the area of computational chemistry and biophysical chemistry, and he has published over 70 papers in the area of physical chemistry and chemical physics. Recently, Dr. Madura has undertaken studies in the use of technology and interactive personal response systems in teaching general and physical chemistry with the goal of improving student comprehension and learning. Dr. Madura has taught chemistry from undergraduate to graduate levels for 15 years and has been the recipient of a Dreyfus Teacher-Scholar Award.

Carey Bissonnette

Carey Bissonnette received his B.Sc. in Chemistry from the University of Waterloo, Ontario and his Ph.D. in Theoretical Chemistry from the University of Camridge. He is currently Continuing Lecturer in the Department of Chemistry at the University of Waterloo. He has won awards for excellence in teaching, including the University of Waterloo’s Distinguished Teacher Award in 2005. Dr. Bissonnette has made extensive use of technology in both the classroom and the laboratory in order to create an interactive environment for his students to learn and explore. For the past several years, he has been actively engaged in undergraduate curriculum development, high school liaison activities, and the coordination of the University’s high school chemistry contests that are written each year by thousands of students around the world.

Dettagli dell'edizione

• Editore: Pearson College Div
• Data di pubblicazione: 2010
• Lingua: Inglese
• ISBN 10: 0136121497
• ISBN 13: 9780136121497
• Rilegatura: Copertina rigida
• Numero di pagine: 1303
• Contatto del produttore: non disponibile
• Persona responsabile: Pearson; riccardo.bacigalupo@sanoma.it; ; Sanoma Italia Via Arconati, 1 �; Milano; Italia