Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.
With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders--such as Werner's syndrome--that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning.
This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century.
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Professor Emeritus of Immunology at UCLA and an internationally recognized authority on cellular immune reactions,William R. Clark is the author of The New Healers: Molecular Medicine in the Twenty-First Century, Sex and the Origins of Death, andAt War Within: The Double Edged Sword of Immunity, all published by OUP.
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Da: BooksRun, Philadelphia, PA, U.S.A.
Hardcover. Condizione: Very Good. It's a well-cared-for item that has seen limited use. The item may show minor signs of wear. All the text is legible, with all pages included. It may have slight markings and/or highlighting. Codice articolo 0195125932-11-1
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Da: World of Books (was SecondSale), Montgomery, IL, U.S.A.
Hardback. Condizione: Very Good. This work covers ageing from a fundamental cell biological perspective. The evolution and developmental genetics of senescence are explained clearly. All the various theories of ageing - the Hayflick limit and telomeric shortening as a possible biological clock, the impacts of somatic mutations, oxidative stress, accumulation of waste materials in cells with age - are explained and critically assessed. The author presents vivid case accounts about disorders that open windows on to the ageing process. The impacts of ageing on the brain and nervous system are given special attention, as are the effects of caloric restriction on maximum lifespan. Codice articolo 00087973557
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Da: Wonder Book, Frederick, MD, U.S.A.
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Da: Better World Books, Mishawaka, IN, U.S.A.
Condizione: Very Good. Former library copy. Pages intact with possible writing/highlighting. Binding strong with minor wear. Dust jackets/supplements may not be included. Includes library markings. Stock photo provided. Product includes identifying sticker. Better World Books: Buy Books. Do Good. Codice articolo GRP101974344
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Da: Better World Books, Mishawaka, IN, U.S.A.
Condizione: Good. Pages intact with minimal writing/highlighting. The binding may be loose and creased. Dust jackets/supplements are not included. Stock photo provided. Product includes identifying sticker. Better World Books: Buy Books. Do Good. Codice articolo 3142128-6
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Da: World of Books Inc, Montgomery, IL, U.S.A.
Hardback. Condizione: Very Good. This work covers ageing from a fundamental cell biological perspective. The evolution and developmental genetics of senescence are explained clearly. All the various theories of ageing - the Hayflick limit and telomeric shortening as a possible biological clock, the impacts of somatic mutations, oxidative stress, accumulation of waste materials in cells with age - are explained and critically assessed. The author presents vivid case accounts about disorders that open windows on to the ageing process. The impacts of ageing on the brain and nervous system are given special attention, as are the effects of caloric restriction on maximum lifespan. Codice articolo CIN0195125932VG
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Da: Steven Edwards, Coalmont, TN, U.S.A.
Hard cover. Sewn binding. Cloth over boards. 234 p. Contains: Illustrations. Audience: General/trade. Clean, tight copy. Very good in very good dust jacket. Codice articolo Alibris0009788
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Da: Granada Bookstore, IOBA, Woodlawn, IL, U.S.A.
Hardcover. Condizione: Very Good. Condizione sovraccoperta: Very Good. The Number Line Indicates A Third Printing Of This Hardcover Edition. Minor Wear With No Chips, Tears Or Writing. Codice articolo 020589
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