Top Drugs: Top Synthetic Routes

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9780198501008: Top Drugs: Top Synthetic Routes

Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis.

Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

L'autore:

Dr John Saunders, Neurocrine Biosciences, 10555 Science Center Drive, San Diego, CA 92121, USA.

Contenuti:

  • 1: Inhibitors of angiotensin converting enzyme as effective antihypertensive agents
  • 2: Blockade of angiotensin-II receptors
  • 3: Calcium channel blockers in the treatment of angina and hypertension
  • 4: Antagonists of histamine receptors (H2) as anti-ulcer remedies
  • 5: Proton pump inhibitors as gastric acid secretion inhibitors
  • 6: Modulation of central serotonin in the treatment of depression
  • 7: Hypnotic, anxiolytic, anticonvulsant and muscle relaxant agents: ligands for benzodiazepine receptors
  • 8: Another histamine receptor: blockers of the H1 receptor for the treatment of seasonal allergic rhinitis
  • 9: Nucleoside analogues which inhibit HIV reverse transcriptase
  • 10: Quinolones as anti-bacterial DNA gyrase inhibitors

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John Saunders
Editore: Oxford University Press, United Kingdom (2012)
ISBN 10: 0198501005 ISBN 13: 9780198501008
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Descrizione libro Oxford University Press, United Kingdom, 2012. Paperback. Condizione libro: New. 241 x 183 mm. Language: English . Brand New Book. Today s top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis. Codice libro della libreria AAU9780198501008

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Saunders, John
Editore: Oxford University Press (2012)
ISBN 10: 0198501005 ISBN 13: 9780198501008
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Descrizione libro Oxford University Press, 2012. Condizione libro: New. This title allows students to see how the organic chemistry taught in undergraduate courses is applied by medicinal chemists in industry. This book describes briefly how each drug works and then reviews the most efficient routes to their synthesis. Series: Oxford Chemistry Primers. Num Pages: 96 pages, numerous line illustrations. BIC Classification: PN; TDCW. Category: (U) Tertiary Education (US: College). Dimension: 245 x 189 x 6. Weight in Grams: 198. . 2012. 1st Edition. Paperback. . . . . . Codice libro della libreria V9780198501008

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Descrizione libro Oxford University Press 2000-05-18, Oxford, 2000. paperback. Condizione libro: New. Codice libro della libreria 9780198501008

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John Saunders
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Descrizione libro Oxford University Press, United Kingdom, 2012. Paperback. Condizione libro: New. 241 x 183 mm. Language: English . Brand New Book. Today s top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis. Codice libro della libreria AAU9780198501008

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Descrizione libro Oxford University Press. Condizione libro: New. This title allows students to see how the organic chemistry taught in undergraduate courses is applied by medicinal chemists in industry. This book describes briefly how each drug works and then reviews the most efficient routes to their synthesis. Series: Oxford Chemistry Primers. Num Pages: 96 pages, numerous line illustrations. BIC Classification: PN; TDCW. Category: (U) Tertiary Education (US: College). Dimension: 245 x 189 x 6. Weight in Grams: 198. . 2012. 1st Edition. Paperback. . . . . Books ship from the US and Ireland. Codice libro della libreria V9780198501008

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Descrizione libro OUP Oxford, 2000. PAP. Condizione libro: New. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Codice libro della libreria BB-9780198501008

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Descrizione libro Oxford University Press. Paperback. Condizione libro: new. BRAND NEW, Top Drugs: Top Synthetic Routes, John Saunders, Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis. Codice libro della libreria B9780198501008

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Descrizione libro Condizione libro: New. Bookseller Inventory # ST0198501005. Codice libro della libreria ST0198501005

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Descrizione libro OUP Oxford, 2000. Condizione libro: New. Codice libro della libreria EH9780198501008

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Descrizione libro Condizione libro: New. Depending on your location, this item may ship from the US or UK. Codice libro della libreria 97801985010080000000

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