Targeted Therapy for Cancer - Rilegato

Rilegato

ISBN 10: 0198508964 ISBN 13: 9780198508960

Casa editrice: OUP Oxford, 2003

Riassunto

The quest for therapeutic specificity is implicit in all branches of medicine. In cancer treatment, where the therapeutic modality is a cytotoxic agent such as radiotherapy or chemotherapy, such specificity is of paramount importance. The growing realisation that current therapeutic options are likely to yield no more than incremental improvements in outcome has fuelled the search for more active targeted approaches.

This book discusses the more archetypal systemic targeted therapies, such as those employing monoclonal antibodies or liposomes, but also includes strategies, such as photodynamic therapy and boron neutron capture therapy, that rely on direct physical targeting of disease. The explosion in our understanding of the molecular biology of cancer in recent years has led to the identification of a number of new potential therapeutic targets.

These factors, combined with the likelihood that yet more valuable information will be gleaned from the Human Genome Project, mean that inevitably, significant clinical activity in this arena is anticipated in the coming years with the very real prospect that gene therapy approaches may find an established role in the standard treatment of some of the common cancers.

This book brings together the very latest research in this field from an international group of experts and will prove invaluable for molecular oncologists, cancer researchers and those involved with clinical trials as well as providing a reference for oncologists who are beginning to use some of these therapies in everyday clinical practice.

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Recensione

Targeted Therapy for Cancer brings together the very latest research in this field from an international group of experts and will prove invaluable for molecular oncologists, cancer researchers and those involved with clinical trials, as well as providing a reference for oncologists who are beginning to use some of these therapies in everyday clinical practice. (Anticancer Research 23)

Contenuti

• Section I
• 1: Bagshawe: The history of targeted therapy for cancer
• 2: Rowlinson-Busza: Preclinical models for the study of targeted therapy
• Section II
• 3: Francis & Begent: Monoclonal antibody targeting therapy: an overview
• 4: Syrigos & Harrington: Antibody-directed enzyme prodrug therapy (ADEPT)
• 5: Batra, Goel, Pavlinkova & Colcher: Monoclonal antibody targeted radionuclide therapy
• 6: Raben & Buchsbaum: Combined external beam radiotherapy and radioimmunotherapy
• Section III
• 7: Pandha: Genetic immunotherapy for cancer
• 8: Harrington & Vile: Targeting of cancer gene therapy
• 9: Rigg & Pandha: Targeted genetic prodrug activation therapy
• 10: Waters & Cunningham: Antisense therapy as a targeted modality
• 11: Melcher, Vile, Bateman & Harrington: Dendritic cells-targeting the antitumor immune response
• 12: Diaz, Chong & Vile: Cell carriers for cancer gene therapy: bridging the gap between targeted vectors and systemic delivery?
• 13: Harrington & Syrigos: Liposomal targeting of cytotoxic drugs
• 14: Vidal, Cardó-Vila, Lahdenranta, Arap & Pasqualini: Targeting blood vessels in vivo by using phage display libraries
• Section IV
• 15: Hamblin: Photodynamic therapy
• 16: Morris & Coderre: Boron neutron capture therapy: a chemically targeted radiation modality
• Section V
• 17: Sela, Schecheter & Yarden: Cancer immunotherapy directed at growth factor receptors: the ErbB/HER network as a prototype
• 18: Culp, Lin, Kleinman, Kogerman, Judware, Miller & Holleran: Targeting the metastatic process

Dettagli dell'edizione

• Editore: OUP Oxford
• Data di pubblicazione: 2003
• Lingua: Inglese
• ISBN 10: 0198508964
• ISBN 13: 9780198508960
• Rilegatura: Copertina rigida
• Numero di pagine: 366
• Redattore: Syrigos Konstantinos N., Harrington Kevin
• Contatto del produttore: non disponibile
• Persona responsabile: Oxford University Press España S.A. of El Parque Empresarial; product.safety@oup.com; ; San Fernando de Henares, Avenida de Castilla, 2 - 28830 Madrid; Madrid; Spagna