The Statistical Evaluation of Medical Tests for Classification and Prediction: 28 - Rilegato

Pepe, Margaret Sullivan

Rilegato

ISBN 10: 0198509847 ISBN 13: 9780198509844

Casa editrice: OUP Oxford, 2003

Riassunto

The use of clinical and laboratory information to detect conditions and predict patient outcomes is a mainstay of medical practice. Modern biotechnology offers increasing potential to develop sophisticated tests for these purposes. This book describes the statistical concepts and techniques for evaluating the accuracy of medical tests. Worked examples include applications to cancer biomarker studies, prospective disease screening studies, diagnostic radiology studies and audiology testing studies. The statistical methodology can be broadly applied for evaluating classifiers and to problems beyond medical settings.

Several measures for quantifying test accuracy are described including the Receiver Operating Characteristic Curve. Pepe presents statistical procedures for the estimation and comparison of those measures among tests. Regression frameworks for assessing factors that influence test accuracy and for comparing tests while adjusting for such factors are presented. The sequence of research steps involved in the development of a test is considered in some detail. Sample size calculations and other issues pertinent to study design are described for tests at various phases of development. In addition, the impacts of missing data and imperfect reference data are addressed. These problems often occur in practice, and modern statistical procedures for dealing with them are discussed. Additional topics that are covered include: meta-analysis for summarizing the results of multiple studies of a test; the evaluation of markers for predicting event time data; and procedures for combining the results of multiple tests to improve classification.

This book should be of interest to quantitative researchers and practicing statisticians. The book also covers the theoretical foundations for statistical inference and should therefore be of interest to academic statisticians including those involved in statistical methodological research in this field.

Su questo libro

Recensione

It is a clear and authorative work which will be invaluable for anyone trying to establish a new diagnostic test. (Derek Robinson, University of Sussex, Brighton)

Statistical results are given a methodical treatment. In each chapter statistical results are motivated, stated and usually proven, and then illustrated on a variety of datasets based on actual trials. Many of the results were developed by Pepe and her colleagues, who have advanced the field in seminal ways. Chapters end with a concluding remarks section, a set of exercises, and proofs of more involved theoretical results, when needed. Concluding remarks sections nicely summarize results and discuss open research questions. References to key papers are given throughout. This structure allows the book to serve as both a classroom text and an excellent reference to the current literature. (Journal of Biopharmaceutical Studies)

I very much recommend this book to a range of audiences, from those wanting an introduction to diagnostic test concepts and methods to active researchers in the area. This book is likely to stimulate considerable progress in development of new statistical methods for diagnostic tests, an area that relative to therapeutics has received little attention from biostatisticians. (Journal of Biopharmaceutical Studies)

L'autore

Margaret Sullivan Pepe is a Professor of Biostatistics, University of Washington; Fred Hutchinson Cancer Research Center, Washington, U.S.A. . Margaret Sullivan Pepe is a Professor of Biostatistics, University of Washington; Fred Hutchinson Cancer Research Center, Washington, U.S.A. .

Dettagli dell'edizione

• Editore: OUP Oxford
• Data di pubblicazione: 2003
• Lingua: Inglese
• ISBN 10: 0198509847
• ISBN 13: 9780198509844
• Rilegatura: Copertina rigida
• Numero di pagine: 318
• Contatto del produttore: Messaggerie Libri; ufficio.anagrafiche@meli.it; ; Via Verdi, 8.; Assago Milano; 20090; Italia