Gene Genealogies, Variation and Evolution: A primer in coalescent theory - Rilegato

Hein, Jotun; Schierup, Mikkel; Wiuf, Carsten

Rilegato

ISBN 10: 0198529953 ISBN 13: 9780198529958

Casa editrice: OUP Oxford, 2004

Riassunto

Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation. Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies. Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia

Su questo libro

Recensione

an excellent and timely book that should appeal to a variety of people in genetics and applied mathematics. (Professor Montgomery Slatkin (Berkeley))

the authors are outstanding experts in the field, and the book is topical and timely. (Professor David Balding (Imperial College))

Hein, Schierup and Wiuf have written the first general book on the coalescent. It is an engaging combination of clear mathematical derivation and real data examples. (Professor Joe Felsenstein (University of Washington))

L'autore

Jotun Hein is a Professor of Bioinformatics Department of Statistics, University of Oxford. Mikkel Schierup and Carsten Wiuf are both at the Bioinformatics Research Center, University of Aarhus, Denmark.

Dettagli dell'edizione

• Editore: OUP Oxford
• Data di pubblicazione: 2004
• Lingua: Inglese
• ISBN 10: 0198529953
• ISBN 13: 9780198529958
• Rilegatura: Copertina rigida
• Numero di pagine: 296
• Contatto del produttore: non disponibile
• Persona responsabile: Ufficio Anagrafiche Messaggerie; ufficio.anagrafiche@meli.it; ; Via Verdi, 8; Assago Milano; 20090; Italia