Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics

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9780199577170: Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics

Cells in our body undergo tightly regulated replication to enable growth to occur in a precise, and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms; it is when these mechanisms fail, and regulation is lost, that cancer can result. Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail.

The third edition of The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents.

Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal processes that become altered in cancer cells, and explains how the failure of these processes can lead to the onset of cancer. Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies.

Written with the student learner in mind, the book features a variety of learning features to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the field, but on acquiring a solid understanding of the essentials of the subject - and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit.

The Molecular Biology of Cancer is an invaluable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control.

Online Resource Centre
The Online Resource Centre to accompany The Molecular Biology of Cancer features:

For students:
· Hyperlinks to primary literature articles featured in the text
· News feeds relevant to cancer biology, drawn from a variety of publications

For registered adopters of the book:
· Figures from the book, available to download
· A test bank of questions, with feedback linked to the book, for use in formative or summative assessment

Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

Recensione:

Dr. Pecorino has done a fantastic job... The book's engaging writing-style and well thought out structure welcomes anyone with an interest in studying cancer in thorough, interesting detail. Reading this text was a pleasure, benefited me greatly educationally and made me feel like being a real part of the teaching - as though things were being explained to me in a one-on-one tutorial, an experience that most other medical textbooks don't provide! ( Amazon.co.uk reviewer)

Reviews of previous edition: Pecorino gets the balance right between cell and molecular biology, focusing on mechanism rather than disease. Importantly the students like the text and can afford to buy the book. Therefore it is a real support to our learning program and actually used by the students. ( Dr Bernard Mahon, Biology Department/Institute of Immunology, National University of Ireland)

Review from first edition The author's infectious enthusiasm as a teacher comes across on every page of this beautifully illustrated book. To guide her readers through this increasingly complex field, she introduces some novel features, including "Special interest" boxes, sections labelled, "Pause to think," well-designed chapter highlights and aids to "Memory refreshment." Given the speed of development of this field, the book is remarkably up to date. ( Sir David Weatherall, Emeritus Regius Professor of Medicine, Oxford University in THES Textbook Guide - February 2006)

Contenuti:

  • 1: Introduction
  • 2: DNA structure and stability: mutations versus repair
  • 3: Regulation of gene expression
  • 4: Growth factor signaling and oncogenes
  • 5: The cell cycle
  • 6: Growth inhibition and tumour suppressor genes
  • 7: Apoptosis
  • 8: Stem cells and differentiation
  • 9: Metastasis
  • 10: The immune system, infections, and inflammation
  • 11: Nutrients, hormones, and gene interactions
  • 12: The cancer industry: drug development, pharmacogenomics, and clinical trial design
  • 13: Cancer in the future: focus on cancer vaccines and technology

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