The Biology and Clinical Applications of Interleukin-2 - Rilegato

Rilegato

ISBN 10: 0199631379 ISBN 13: 9780199631377

Casa editrice: IRL Press, 1990

Riassunto

This publication presents the proceedings of the international symposium held at the University of Sheffield in 1989. It provides an up-to-date account of many important aspects of interleukin-2 (IL-2), and its clinical application. The molecular structure of IL-2 and its receptor subunits provide a basis for understanding lymphocyte activation by IL-2 and the generation of effector cells capable of mediating cytotoxicity towards tumours. Researchers of international standing present authoritative views on the molecular aspects of cell signalling, allowing speculation of the in vivo pathways of activation likely to be important in determining clinical responses. Attention has focussed on the use of cytokines, particularly IL-2, for the treatment of cancer. The recent results from clinical trials using IL-2 and adoptive cellular therapy provide a clear account of the clinical progress, and of the problems encountered in attempting to improve the therapeutic benefit of IL-2. The importance of mechanisms which subverse IL-2 responses is also given.

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Recensione

'All articles are fully illustrated and very extensively referenced. This book will be a valuable source of information for researchers, clinicians and students in the fields of immunology, pharmacology, oncology, biochemistry and molecular biology.'Drugs of Today

'This is a major update of the molecular biology of IL-2 and its receptor.' Aslib Book List, Vol.56, No.4, April 1991

'...the great virtue of this book is that it includes the most important findings on the basic as well as on the clinical aspects of IL-2. ...there is no doubt that researchers, clinicians and students in immunology or oncology will find this volume to be a valuable source of information relevant to the structure and function of IL-2, from both the research and clinical perspectives.'Molecular Immunology

'this book provides a useful guide to this interesting area of experimental cancer therapy, particularly for those clinicians and scientists who are not familiar with the field.'F. Balkwill, Imperial Cancer Research Fund, European Journal of Cancer, Vol. 28A, No. 4/5. 1992

Contenuti

B. Altrock, W.C. Kenney, T. Boone, & P. Hunt: Molecular structure and biology of interleukin-2; G. Ju, K. Sauve, P. Bailon, W.-H. Tsien, P. Lin, J. Hakimi, & V. Toome : Structure-activity relationships of human IL-2: identification of residues that bind the IL-2 receptor; T. Diamanstein: Interleukin-2 and the interleukin-2 receptor complex; J. Ortaldo: Lymphokine-activated killer cells: regulation of activity; N.A. Mitchison: IL-2 as a short range physiological mediator; F. Triebel & T. Hercend: A reconciled view of the non-MHC requiring cytotoxicity phenomenon; K. Karre: Specificities involved in recognition of tumour target cells by IL-2 activated NK cells and T cells: "one receptor" versus "multiple choice" models; J.C. Hiserdot: Adherent lymphokine-activated killer cells (A-LAK cells): anti-tumour activity in vitro and in vivo; J. Graves, S. Lucas, & D. Cantrell: The regulation of protein kinase C in T Lymphocytes; R.H. Wiltrout, H. Futami, H.A. Young, R.L. Hurnung, & T.J. Sayers: Involvement of cytokines in combined modality preclinical approaches to cancer treatment; S.P. Creekmore, D.L. Longo, & W.J. Urba: The development of regimens for combination immunotherapy; R.B. Herberman, P. Basse, R. Jain, R.J. Melder, R.H. Goldfarb, E. Gorelik, M.S. Ernstoff, J.M. Kirkwood, & T.L. Whiteside: Approaches to immunotherapy with defined populations of IL-2 cultured NK cells, immune T cells, or tumour infiltrating lymphocytes; J. Yannelli, J. Maleckar, W. West, & R. Oldham: Cellular biotherapy of cancer: generation, characterization, and use of anti-tumour effector cells; J.T. Rubin, S.A. Rosenberg, & M.T. Lotze: The efficacy of high dose recombinant interleukin-2 based immunotherapy in man; P.A. Palmer & C.R. Franks: Prospects of IL-2 in cancer therapy; P.J. Guillou: Tumour escape mechanisms; G. Gallagher & P.J. Guillou: Open paper and poster sections.

Dettagli dell'edizione

• Editore: IRL Press
• Data di pubblicazione: 1990
• Lingua: Inglese
• ISBN 10: 0199631379
• ISBN 13: 9780199631377
• Rilegatura: Copertina rigida
• Numero di pagine: 200
• Redattore: Rees Robert C.
• Contatto del produttore: non disponibile
• Persona responsabile: Ufficio Anagrafiche Messaggerie; ufficio.anagrafiche@meli.it; ; Via Verdi, 8; Assago Milano; 20090; Italia