Randomised Response-Adaptive Designs in Clinical Trials - Brossura

Atkinson, Anthony C; Biswas, Atanu

Brossura

ISBN 10: 0367378973 ISBN 13: 9780367378974

Casa editrice: Routledge, 2019

Riassunto

Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training.

After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.

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Informazioni sull'autore

Anthony C. Atkinson is an Emeritus Professor of Statistics at the London School of Economics and Political Science.

Atanu Biswas is a professor in the Applied Statistics Unit at the Indian Statistical Institute, Kolkata.

Dettagli dell'edizione

• Editore: Routledge
• Data di pubblicazione: 2019
• Lingua: Inglese
• ISBN 10: 0367378973
• ISBN 13: 9780367378974
• Rilegatura: Copertina flessibile
• Numero edizione: 1
• Numero di pagine: 340
• Contatto del produttore: Taylor and Francis, GPSR Taylor and Francis; gpsr@taylorandfrancis.com; ; Taylor & Francis Verlag GmbH, Kaufingerstraße 24; München; 80331; Germania