Statistical Methods in Drug Combination Studies - Brossura

Libro 50 di 151: Chapman & Hall/CRC Biostatistics
 
9780367738624: Statistical Methods in Drug Combination Studies
Brossura
ISBN 10: 0367738627 ISBN 13: 9780367738624
Casa editrice: Routledge, 2020

Sinossi

The growing interest in using combination drugs to treat various complex diseases has spawned the development of many novel statistical methodologies. The theoretical development, coupled with advances in statistical computing, makes it possible to apply these emerging statistical methods in in vitro and in vivo drug combination assessments. However, despite these advances, no book has served as a single source of information for statistical methods in drug combination research, nor has there been any guidance for experimental strategies.

Statistical Methods in Drug Combination Studies fills that gap, covering all aspects of drug combination research, from designing in vitro drug combination studies to analyzing clinical trial data. Featuring contributions from researchers in industry, academia, and regulatory agencies, this comprehensive reference:



  • Describes statistical models used to characterize dose–response patterns of monotherapies and evaluate the combination drug synergy


  • Offers guidance for estimating interaction indices and constructing their associated confidence intervals to assess drug interaction


  • Introduces a practical and innovative Bayesian approach to Phase I cancer trials, including actual trial examples to illustrate use


  • Examines strategies in the fixed-dose combination therapy clinical development via case studies stemming from regulatory reviews


  • Evaluates computational tools and software packages used to apply novel statistical methods in combination drug development

Statistical Methods in Drug Combination Studies provides researchers with a solid understanding of the available statistical methods and computational tools and how to apply them in drug combination studies. The book is equally useful for statisticians to become better equipped to deal with drug combination study design and analysis in their practice.

Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

Informazioni sull?autore

Wei Zhao, Harry Yang

Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.

Editore
Routledge
Data di pubblicazione
2020
Lingua
Inglese
ISBN 10 
0367738627
ISBN 13 
9780367738624
Rilegatura
Copertina flessibile
Numero edizione
1
Numero di pagine
240
Redattore
Zhao Wei, Yang Harry
Contatto del produttore
non disponibile
Persona responsabile
non disponibile

Altre edizioni note dello stesso titolo

9781482216745: Statistical Methods in Drug Combination Studies

Edizione in evidenza

ISBN 10:  1482216744 ISBN 13:  9781482216745
Casa editrice: Chapman and Hall/CRC, 2014
Rilegato