Cancer Metastatis and the Lymphovascular System: Bases for Rational Therapy: Basis for Rational Therapy: 135 - Rilegato

Rilegato

ISBN 10: 0387692185 ISBN 13: 9780387692180

Casa editrice: Springer Verlag, 2007

Riassunto

This book details the anatomy and physiology of the lymphovascular system as well as describes the mechanisms of metastasis. It provides readers with an understanding of immune responses of draining lymph nodes against cancer. Coverage also explains the rationale of adopting molecular therapeutics against growth factor receptors, apoptotic factors, signaling pathways and angiogenesis.

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Sentinel lymph node (SLN) procedures have opened a window of opportunity for the study of micrometastasis. In eighty percent (80%) of metastasis there lies an orderly pattern of progression via the lymphatic network, while 20% of the time systemic metastasis occurs, bypassing the lymphatic system. During the past two decades, significant progress has been achieved in understanding the anatomical, functional, cellular and molecular aspects of the lymphovascular system and the metastasis process.

· Molecular imaging advances help to localize early cancers more precisely.

· Current status of the immune responses in the draining lymph nodes against cancer is summarized.

· New paradigms of early cancer growth, proliferation, overcoming apoptosis are exploited in the development of anticancer treatment.

In this book, basic scientists and clinicians exchange ideas so that laboratory findings can be applied to clinical dilemmas, and clinical problems can be targeted for research in the laboratory.

 

Series editor's comments:

"Cancer metastasis remains the greatest challenge for oncologists. The role of the lymphovascular system is critical and a focus of intense investigations. This text covers a spectrum of relevant research and clinical issues that impact on our understanding of this process."

Steven T. Rosen, MD

Series Editor

Dettagli dell?edizione

• Editore: Springer Verlag
• Data di pubblicazione: 2007
• ISBN 10: 0387692185
• ISBN 13: 9780387692180
• Rilegatura: Copertina rigida
• Lingua: Inglese
• Numero edizione: 1
• Numero di pagine: 309
• Redattore: Leong Stanley P. L.
• Contatto del produttore: non disponibile