Structural and Functional Organization of the Synapse - Rilegato

Rilegato

ISBN 10: 0387772316 ISBN 13: 9780387772318

Casa editrice: Springer Verlag, 2008

Riassunto

This new Springer volume, which comes complete with a free DVD, is a comprehensive and detailed overview of the synapse with emphasis on the glutamatergic synapse. Most chapters relate the synapse’s functional aspects to its molecular mechanisms. This approach shows which mechanisms are characterized on both the functional and structural level and can thus be considered firmly established. It’s an important text for neuroscientists and disease-oriented clinicians in neurology.

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Contenuti

Diversity in Synapse Structure and Composition.- The Role of Glutamate Transporters in Synaptic Transmission.- Structure and Function of Vertebrate and Invertebrate Active Zones.- Neurotransmitter Release Machinery: Components of the Neuronal SNARE Complex and Their Function.- The Molecular Machinery for Synaptic Vesicle Endocytosis.- Initiation and Regulation of Synaptic Transmission by Presynaptic Calcium Channel Signaling Complexes.- Adhesion Molecules at the Synapse.- Dendritic Organelles for Postsynaptic Trafficking.- Structure and Mechanism of Action of AMPA and Kainate Receptors.- Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity.- Structure and Function of the NMDA Receptor.- Molecular Properties and Cell Biology of the NMDA Receptor.- Surface Trafficking of Membrane Proteins at Excitatory and Inhibitory Synapses.- Scaffold Proteins in the Postsynaptic Density.- Ca2+ Signaling in Dendritic Spines.- Postsynaptic Targeting of Protein Kinases and Phosphatases.- Long-Term Potentiation.- Homeostatic Synaptic Plasticity.- Ubiquitin and Protein Degradation in Synapse Function.- Signaling from Synapse to Nucleus.- Molecular Organization of the Postsynaptic Membrane at Inhibitory Synapses.- Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology.- Glia as Active Participants in the Development and Function of Synapses.- Plasticity of Dentate Granule Cell Mossy Fiber Synapses: A Putative Mechanism of Limbic Epileptogenesis.- Stroke – A Synaptic Perspective.- and Pathological Pain.

Dalla quarta di copertina

Synapses play a central role in the brain by mediating signal transmission between neurons. This book provides a fundamental description of the synapse by leading experts in the field. Each individual synapse carries out its numerous functions in a tiny space, thereby requiring an exquisite molecular and functional arrangement. This book describes the molecular structure and cellular function of central synapses in the brain, providing a detailed view of the brain’s fundamental unit of information storage.

Dettagli dell?edizione

• Editore: Springer Verlag
• Data di pubblicazione: 2008
• ISBN 10: 0387772316
• ISBN 13: 9780387772318
• Rilegatura: Copertina rigida
• Lingua: Inglese
• Numero edizione: 1
• Numero di pagine: 801
• Redattore: Hell Johannes W., Ehlers Michael D.