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"Cancer viruses" have played a paradoxical role in the history of cancer research. Discovered in 1911 by Peyton Rous (1) at the Rockefeller Institute, they were largely ignored for several decades. Witness his eventual recognition for a Nobel Prize, but not until 1966-setting an all time record for latency, and testimony to one more advantage of longevity. In the 1950s, another Rockefeller Nobelist, Wendell Stanley, spearheaded a campaign to focus attention on viruses as etiological agents in cancer, his plat form having been the chemical characterization of the tobacco mosaic virus as a pure protein-correction, ribonucleoprotein-in 1935 (2). This doctrine was a centerpiece of the U.S. National Cancer Crusade of 1971: if human cancers were caused by viruses, the central task was to isolate them and prepare vaccines for immunization. At that point, many observers felt that perhaps too much attention was being devoted to cancer viruses. It was problematic whether viruses played an etiological role in more than a handful of human cancers.
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Contenuti
1 Introduction.- 2 Assays: Tools of the New Biology.- 3 Viruses and Oncogenes.- 4 Human T Cell Lymphotropic/Leukemia Viruses.- 5 Cellular Proto-oncogenes.- 6 Oncogenes and Human Cancers.- 7 src and Related Protein Kinases.- 8 Growth Factors and Receptors.- 9 ras Family of Oncogenes.- 10 myc and Other Nuclear Oncogenes.- 11 Additional Oncogenes.- 12 Transgenic Mice: Direct In Vivo Assay for Oncogenes.- 13 Potential Diagnostic Uses of Oncogenes.- 14 Potential Therapeutic Applications of Oncogenes.- 15 Oncogene Paradigm: Contribution to a Fundamental Understanding of Malignancy.- Appendix: Oncogenes and Related Genes.
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Book by Burck Kathy B Liu Edison T Larrick James W
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Oncogenes: An Introduction to the Concept of Cancer Genes
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Oncogenes. an introduction to the concept of cancer genes.
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Oncogenes : An Introduction to the Concept of Cancer Genes
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Oncogenes: An Introduction to the Concept of Cancer Genes
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Oncogenes - An Introduction To The Concept Of Cancer Genes
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Oncogenes: An Introduction to the Concept of Cancer Genes
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Springer, 1989
ISBN 10: 0387964231
ISBN 13: 9780387964232
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Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Cancer viruses have played a paradoxical role in the history of cancer research. Discovered in 1911 by Peyton Rous (1) at the Rockefeller Institute, they were largely ignored for several decades. Witness his eventual recognition for a Nobel Prize, but not. Codice articolo 5912732
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Oncogenes
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -'Cancer viruses' have played a paradoxical role in the history of cancer research. Discovered in 1911 by Peyton Rous (1) at the Rockefeller Institute, they were largely ignored for several decades. Witness his eventual recognition for a Nobel Prize, but not until 1966-setting an all time record for latency, and testimony to one more advantage of longevity. In the 1950s, another Rockefeller Nobelist, Wendell Stanley, spearheaded a campaign to focus attention on viruses as etiological agents in cancer, his plat form having been the chemical characterization of the tobacco mosaic virus as a pure protein-correction, ribonucleoprotein-in 1935 (2). This doctrine was a centerpiece of the U.S. National Cancer Crusade of 1971: if human cancers were caused by viruses, the central task was to isolate them and prepare vaccines for immunization. At that point, many observers felt that perhaps too much attention was being devoted to cancer viruses. It was problematic whether viruses played an etiological role in more than a handful of human cancers. 320 pp. Englisch. Codice articolo 9780387964232
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