Molecular and Cellular Aspects of the Drug Addictions - Rilegato

Rilegato

ISBN 10: 038796827X ISBN 13: 9780387968278

Casa editrice: Springer Verlag, 1989

Riassunto

In 1970 I gave up the chairmanship of the Department of Pharmacology at Stanford University Schoel of Medicine to devote full time to basic and clinical research on problems of drug addiction. In 1971 I developed the method of radioligand binding that led to the important characterization of opioid receptors in several laboratories. The extraordinary specificity of these receptors for morphine and related opiates suggested the likelihood that there were naturally occurring morphine-like molecules in the brain and other tissues. The systematic search for these molecules culminated in 1979 in the discovery, by my group, ofthe dynorphin peptides-one of the three families of opioid peptides, the first of which (the enkephalin family) had been discovered in Aberdeen, Scotland, in 1975. I also became involved in clinical research on the pharmacologic treatment of heroin addicts, for which I established the first large methadone mainte­ nance treatment program in California. My basic and clinical research experience convinced me that an institution encompassing laboratory research, studies on normal human volunteers, and treatment research, under a single roof, could expedite progress in understanding the drug addictions. That concept was transformed into reality by the founding, in 1974, of the Addiction Research Foundation of Palo Alto, California. The funds for construction of a laboratory were provided by a generous grant from the Drug Abuse Council (a consortium of several foundations), the president of which was Thomas L. Bryant.

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Contenuti

Contents: The Nature of Addiction: An Analysis of the Problem.- Neuroanatomical and Neurochemical Substrates of Drug-Seeking Behavior: Overview and Future Directions.- Bradykinin and Pain.- Neurochemical Aspects of Addiction: Opioids and Other Drugs of Abuse.- Which Molecular and Cellular Actions of Ethanol Mediate Reinforcement?.- Presynaptic Inhibition, Presynaptic Facilitation and the Molecular Logic of Second-Messenger Systems.- Applications of Molecular Genetics to Neuropsychiatric Disorders.- Index.

Dettagli dell'edizione

• Editore: Springer Verlag
• Data di pubblicazione: 1989
• Lingua: Inglese
• ISBN 10: 038796827X
• ISBN 13: 9780387968278
• Rilegatura: Copertina rigida
• Numero di pagine: 238
• Redattore: Goldstein Avram
• Contatto del produttore: non disponibile
• Persona responsabile: CMN Printpool Inh. Mathis Neumann; https://www.also.com/ec/cms5/en_6000/6000/index.jsp; ; Friedrich-Karl-Str. 9; Hamburg; Germania