Regulation of the Ras Signalling Network: 6 - Rilegato

Maruta, Hiroshi; Burgess, Antony

Rilegato

ISBN 10: 0412118610 ISBN 13: 9780412118616

Casa editrice: SPRINGER NATURE, 1996

Riassunto

This book, which was written by the current leaders in the field of Ras research, provides the readers with the most comprehensive and up-to-date view of the major oncogene Ras. This volume is valuable not only for university students in molecular biology, biochemistry or medicine, but also for senior scientists currently conducting cancer research.

Su questo libro

Contenuti

1. Genetics of RAS Signaling in Drosophila.- I. Introduction.- II. Background to the Experimental Systems.- III. Protein Tyrosine Kinase Receptors.- IV. Linking RAS with Tyrosine Kinase Receptors.- V. A Kinase Cascade Downstream of RAS.- VI. Nuclear Events.- VII. Concluding Remarks.- 2. RAS-Mediated Signal Transduction in C. elegans.- I. Introduction.- II. Genetic Approaches Used to Study Vulval Signal Transduction.- III. Genetic and Molecular Analysis of the let-60 RAS Gene.- IV. Genes Acting Upstream of RAS.- V. Genes Acting Downstream of RAS.- VI. Multiple Functions of the let-60 RAS-mediated Signal Transduction Pathway During C elegans Development.- 3. Mammals I: Regulation of RAS Activation.- I. Introduction.- II. Growth Factor/Cytokine Signaling.- III. Growth Factor Cascades: Autocrine Stimulation.- 4. Prenylation of RAS and Inhibitors of Prenyltransferases.- I. Introduction.- II. C-Terminal Modification of RAS Proteins.- III. Farnesyltransferase and Geranylgeranyltransferases.- IV. Mutational Analyses of Prenyltransferases.- V. Inhibitors of Prenylation.- VI. Biological Effects of Prenyltransferase Inhibitors.- 5. Mammals II: Downstream of RAS and Actin-Cytoskeleton.- I. RAS GAPs.- II. Oncogenic Mutations of RAS.- III. Effectors of RAS.- IV. Actin-Cytoskeleton.- V. G Proteins in the Rho Family (Rho, Rac and CDC42).- VI. RAS-Activated or -Repressed Genes.- 6. From RAS to MAPK: Cell-Free Assay System for RAS- and Rap 1-Dependent B-Raf Activation.- I. Introduction.- II. Cell-free Assay System for the RAS-dependent Activation of the MAP Kinase Cascade in Xenopus Oocyte Cytosol.- III. REKS.- IV. Raf Activation.- V. Conclusion.

Dettagli dell'edizione

• Editore: SPRINGER NATURE
• Data di pubblicazione: 1996
• Lingua: Inglese
• ISBN 10: 0412118610
• ISBN 13: 9780412118616
• Rilegatura: Copertina rigida
• Numero di pagine: 202
• Contatto del produttore: non disponibile
• Persona responsabile: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3; Heidelberg; 69115; Germania