9780412131608: Metals in Biochemistry

Sinossi

We must ignore, on the one hand, the gross physiological effects of metal deficiency or toxicity, and on the other, the many model studies which have been stimulated by the unusual properties of metals in biological systems.

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Contenuti

1 The essential metals and their evolution.- 1.1 The major metals.- 1.2 The minor metals.- 1.3 Metals and early biochemical evolution.- 2 The non-redox roles of metals ions.- 2.1 Active sites of the non-redox metals.- metal activity, specificity and selectivity.- the alkali metals.- magnesium.- calcium.- zinc and other metals.- 2.2 Regulatory and trigger roles of metal ions.- metal ions and regulatory enzymes.- the trigger roles of calcium.- secretion from cytoplasmic granules.- activation of muscle contraction.- 3 Electron transfer and redox reactions.- 3.1 Metals as redox catalysts.- 3.2 Electron carrier proteins.- cytochromes.- the blue copper site.- iron-sulphur proteins.- 3.3 Some enzymes containing molybdenum, cobalt and iron.- molybdenum.- cobalt.- ribonucleotide reductases.- 3.4 Electron transfer in respiration and photosynthesis.- 4 Dealing with oxygen.- 4.1 The activation and toxicity of oxygen.- 4.2 Oxygen carriers.- myoglobin and haemoglobin.- haemo-cyanin.- haemerythrin.- 4.3 Superoxide dismutases.- 4.4 Oxidases.- cytochrome oxidase.- the blue oxidases.- 4.5 Oxygenases.- monoxygenases.- dioxygenases.- 4.6 Hydroperoxidases.- 4.7 Some oxygen-activating groups.- 5 Metal metabolism.- 5.1 Microbial ion carriers.- ionophores.- siderophores.- 5.2 The major metals.- translocation across membranes.- the internal fluid media of animals.- 5.3 The minor metals.- iron.- zinc.- copper.- other metals.- Suggestions for further reading.

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