As knowledge of biological systems and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. Smith and Williams' Introduction to the Principles of Drug Design and Action, 4th Edition provides an introduction to the principles of rational drug design, including both novel and established approaches. This new edition adopts a 'from-bench-to-marketplace' approach, using real examples where possible. In addition to a comprehensive update of the previous edition, new advances in molecular techniques, biotechnological applications and computer-aided design have been added.
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Processes of Drug Handling by the Body. The Design of Drug Delivery Systems. Experimental Pharmacokinetics: Design and Analysis. Intermolecular Forces and Molecular Modeling. Drug Chirality and its Pharmacological Consequences. Quantitative Structure - Activity Relationships and Drug Design. From Programme Sanction to Clinical Trials: A Partial View of the Quest for Arimidex (TM), a Potent, Selective Inhibitor of Aromatase. Pro-drugs. Design of Enzyme Inhibitors as Drugs. Stabilisation of Peptide Drugs by Chemical Manipulation. Combinational Chemistry: High-throughput Screening. Recombinant DNA Technology: Monoclonal Antibodies. Human Genome and its Implications to Drug Design: Pharmacogenetics and Pharmacogenomics. The Chemotherapy of Cancer. Neurotransmitters, Agonists and Antagonist. Design of Antimicrobial and Anti-fungal Agents. Bio-inorganic Chemistry and its Pharmaceutical Applications.
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