The fourth edition of this leading text reflects the new direction and growth of the field of hematology as an academic and clinical discipline. Edited and written by practitioners who are the leaders of the field, the book covers both the basic scientific foundations of hematology and its clinical aspects. It provides practitioners with the most comprehensive, authoritative, up-to-date information in hematology. The table of contents has been thoroughly revised with many new chapters added, reflecting the rapidly changing nature of the molecular and cellular areas of the specialty. This definitive resource is the one comprehensive book needed by every practicing hematologist.
Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.
Part I. MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY
Chapter 1 Anatomy and Physiology of the Gene
Edward J. Benz, Jr., Andrew Wagner, Nancy Berliner
Chapter 2 Genomic Approaches to the Study of Hematologic Science
Todd Golub and Scott Armstrong
Chapter 3 Protein Synthesis, Processing, and Degradation
Garabet G. Toby and David L. Wiest
Chapter 4 Protein Architecture: Relationship of Form and Function
Alan C. Rigby and Barbara C. Furie
Chapter 5 Regulation of Cellular Response
Benjamin G. Neel and Christopher Carpenter
Chapter 6 Cell Adhesion
Rodger P. McEver
Chapter 7 Control of Cell Division
William M.F. Lee and Chi V. Dang
Chapter 8 Cell Death
David M. Hockenbery and Stanley J. Korsmeyer
Chapter 9 Pharmacogenomics and Hematological Diseases
Loe Kager and William E. Evans
Part II. IMMUNOLOGIC BASIS OF HEMATOLOGY
Chapter 10 Overview and Compartmentalization of the Immune System
Leland D. Powell and Linda G. Baum
Chapter 11 B-Cell Development
Kenneth Dorshkind and David J. Rawlings
Chapter 12 T-Cell and NK-Cell Immunity
Carol Clayberger and Alan M. Krensky
Chapter 13 Dendritic Cell Biology
Zbigniew M. Szczepiorkowski and Nina Bhardwhaj
Chapter 14 Regulation of Activation of B and I Lymphocytes
John C. Monroe and Lawrence Turka
Chapter 15 Leukocyte Trafficking
James J. Campbell, Steven Sloan, and Leslie E. Silberstein
Chapter 16 Tolerance and Autoimmunity
Mark J. Shlomchik
Part III. BIOLOGY OF STEM CELLS AND DISORDERS OF HEMATOPOIESIS
Chapter 17 Stem Cell Model of Hematopoiesis
Anskar YH Leung and Catherine M. Verafaillie
Chapter 18 Bone Marrow Microenvironment
Mo Dao and Catherine M. Verfaillie
Chapter 19 The Humeral Regulation of Hematopoiesis
Montaser Shaheen and Hal Broxmeyer
Chapter 20 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
Thalia Papayannopoulou, Alan D'Andrea, Janis Abkowitz, and Anna Rita Migliaccio
Chapter 21 Granulopoiesis and Monocytopoiesis
Arati Khanna-Gupta and Nancy Berliner
Chapter 22 Thrombocytopoiesis
Michael W. Long and Ronald Hoffman
Chapter 23 Thrombocytopenia Due to Decreased Platelet Production
J. B. Opalinska and Alan M. Gewirtz
Chapter 24 Inherited Forms of Bone Marrow Failure
Melvin H. Freedman
Chapter 25 Aplastic Anemia
Neal S. Young and Jaroslaw P. Maciejewski
Chapter 26 Paroxysmal Nocturnal Hemoglobinuria
Rob A. Brodsky
Chapter 27 Pure Red Cell Aplasia
Emmanuel N. Dessypris
Part IV. RED BLOOD CELLS
Chapter 28 Pathobiology of the Human Erythrocyte and Its Hemoglobins
Martin H. Steinberg, Edward J. Benz, Jr., Henry Adewoye, and Ben Ebert
Chapter 29 Approach to Anemia in the Adult and Child
Peter Marks and Bertil Glader
Chapter 30 Anemia of Chronic Diseases
Lawrence B. Gardner and Edward J. Benz, Jr.
Chapter 31 Pathology of Iron Metabolism
Nancy C. Andrews
Chapter 32 Disorders of Iron Metabolism : Iron Deficiency and Overload
Gary M. Brittenham
Chapter 33 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
James S. Wiley and Michael R. Moore
Chapter 34 Megablastic Anemias
Aook C. Anthony
Chapter 35 Thalassemia Syndromes
Bernard G. Forget and Alan R. Cohen
Chapter 36 Pathology of Sickle Cell Disease
Robert P. Hebbel
Chapter 37 Sickle Cell Disease
Stephen H. Embury, Elliot Vichinsky, and Yogen Saunthararajah
Chapter 38 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and
Methemoglobinemias
Edward J. Benz, Jr.
Chapter 39 Red Cell Enzymopathies
Xylina T. Gregg and Josef T. Prchal
Chapter 40 Red Cell Membrane Disorders
Patrick G. Gallagher and Petr Jarolim
Chapter 41 Autoimmune Hemolytic Anemias
Melody J. Cunningham and Leslie E. Silberstein
Chapter 42 Extrinsic Nonimmune Hemolytic Anemias
Stanley L. Schrier and Erin Gourley Reid
Part V. HOST DEFENSE AND ITS DISORDERS
Chapter 43 Complement Biology and Immunoglobulin
Gregory Kline, Robert Barrington, and Michael C. Carroll
Chapter 44 Normal Phagocyte Structure and Function
Robert L. Baehner
Chapter 45 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes
Steven J. Ackerman and Joseph H. Butterfield
Chapter 46 Disorders of Phagocyte Function and Number
Mary C. Dinauer and Thomas D. Coates
Chapter 47 Disorders of Lymphocyte Function
Aileen M. Cleary, Richard A. Insel, and David B. Lewis
Chapter 48 Histiocytic Disorders
Jeffrey M. Lipton and Robert J. Arceci
Chapter 49 Lysosomal Storage Diseases: Perspective and Principles
Gregory A. Grabowski and Nancy Leslie
Chapter 50 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
Stephen Gottschalk, Cliona M. Rooney, and Helen E. Heslop
Chapter 51 The Spleen and Its Disorders
Susan B. Shurin
Chapter 52 Basophils, Mast Cells, and Systemic Mastocytosis
Robert I. Parker and Dean D. Metcalfe
Part VI. HEMATOLOGIC MALIGNANCIES
Chapter 53 Conventional Cytogenetics and Molecular Cytogenetics in Hematological
Malignancies
Gordon Dewald and Rhett P. Ketterling
Chapter 54 The Molecular Basis of Neoplasia
Carol Westbrook
Chapter 55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
Stanton Gerson, Kapil N. Bhalla, Steven Grant, Richard Creeger, Nizar Bahlis
Chapter 56 Radiation Therapy in the Treatment of Hematologic Malignancies
Andrea K. Ng and Peter M. Mauch
Chapter 57 Clinical Use of Hematopoietic Growth Factors
Jacob M. Rowe and Irit Avivi
Chapter 58 Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma
Thomas E. Witzig
Chapter 59 Pathobiology of Acute Myeloid Leukemia
Brian Huntly and D. Gary Gilliland
Chapter 60 Clinical Manifestations of Acute Myeloid Leukemia
Kenneth B. Miller and Philip R. Daoust
Chapter 61 Therapy for Acute Myeloid Leukemia
Elihu H. Estey and Hagop Kantarijan
Chapter 62 Acute Myeloid Leukemia in Children
Gary V. Dahl and Howard J. Weinstein
Chapter 63 Pathobiology of Acute Lymphoblastic Leukemia
A. Thomas Look and Adolpho Ferrando
Chapter 64 Clinical Manifestations of Acute Lymphoblastic Leukemia
Stacey L. Berg, C. Philip Steuber, and David G. Poplack
Chapter 65 Treatment of Childhood Acute Lymphoblastic Leukemia
Lewis B. Silverman, Stephen E. Sallan, and Harvey J. Cohen
Chapter 66 Acute Lymphoblastic Leukemia in Adults
Dieter Hoelzer and Nicola Gokbudget
Chapter 67 Myelodysplastic Syndrome: Biology and Treatment
Richard Stone and Daniel DeAngelo
Chapter 68 Polycythemia Vera
Ronald Hoffman, Kelty R. Baker and Joe Prchal
Chapter 69 Chronic Myeloid Leukemia
Charles Sawyers and Neil P. Shah
Chapter 70 Myelofibrosis with Myeloid Metaplasia
Ronald Hoffman and Farhad Ravandi-Kashani
Chapter 71 Essential Thrombocythemia
Steven Fruchtman and Ronald Hoffman
Chapter 72 Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children
David M. Loeb, Robert P. Castleberry, and Cindy L. Schwartz
Chapter 73 Pathobiology of Non-Hodgkin Lymphomas
Gianluca Gaidano and Riccardo Dalla-Favera
Chapter 74 Patho-Biology of Hodgkin's Lymphoma
Stefano A. Pileri, Brunangelo Falini and Harold Stein
Chapter 75 Hodgkin's Disease: Clinical Manifestations, Staging, and Therapy
Volker Diehl, Daniel Re, and Andreas Josting
Chapter 76 The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas
Elaine Jaffe and Stefania Piltaluga
Chapter 77 Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma John G. Gribben and Ann S. La Casce
Chapter 78 Malignant Lymphomas in Childhood
John T. Sandlund, Jr.Michael P. Link
Chapter 79 Chronic Lymphocytic Leukemia
Dilip V. Patel and Kanti R. Rai
Chapter 80 Hairy Cell Leukemia
Annaadriana Zakanja, LoAnne C. Petersen, and Martin S. Tallman
Chapter 81 Cutaneous T-Cell Lymphomas
Timothy M. Kuzel, Joan Guitart, and Steven T. Rosen
Chapter 82 AIDS-Related Lymphomas
David T. Scadden
Chapter 83 Multiple Myeloma and Other Plasma Cell Disorders
Guido Tricot
Chapter 84 Immunoglobulin Light Chain Amyloidosis (Primary Amyloidosis, AL)
Morrie A. Gertz, Martha Q. Lacy, Angela Dispenzien
Chapter 85 Atypical Immune Lymphoproliferations
Timothy C. Greiner and Thomas G. Gross
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