Heart Failure: Scientific Principles and Clinical Practice - Rilegato

 
9780443075018: Heart Failure: Scientific Principles and Clinical Practice

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A substantial international reference on heart failure. This volume will address the major management issues for patients with acute and chronic heart failure and will guide professional diagnosis.

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L'autore

Philip A Poole-Wilson BA, MB, BChir, MA, MD, FRCP, FACC, FESC, FMedSci is the British Heart Foundation Simon Marks Professor of Cardiology and Head of Cardiovascular Sciences, National Heart & Lung Institute (NHLI), Imperial College London and Honorary Consultant Physician at the Royal Brompton & Harefield Hospitals, London, UK. He qualified (MB) in 1967. He held clinical positions until 1972 at various hospitals in London and was a British American Travelling Research Fellow at the University of California in Los Angeles (UCLA) from 1973 to 1974. His thesis was accepted for MD (Cantab) in 1975. After holding positions as Senior Lecturer (National Heart Hospital) and Reader in Cardiology he was appointed as Professor of Cardiology at the University of London in 1983. In the period 1990-2000 he served as Clinical Director, Research Director, and Non-Executive Board Director of the Royal Brompton Hospital. He was Head of the Division (National Heart and Lung Institute (NHLI)) in the Faculty of Medicine of Imperial College London from 1997 to 2000. He has been a member of the Council and Senate of Imperial College London. Professor Poole-Wilson's other appointments include President of the European Society of Cardiology (1994-1996) and President of the World Heart Federation (2003-2005) of which he is currently the Past-President. He has served on many committees within the Department of Health, MRC, Research Assessment Exercise, British Heart Foundation and Welcome Trust in the UK. He is on the Editorial Board of several leading journals and is Chairman/Member of the Steering or Monitoring Committees of several large clinical trials. He was awarded Le Prix Europe et Medecine 2001 de l'Institut des Sciences de la Sante, Paris and has received many other awards. As of March 2006 he had 459 citations in PubMed. His specialist interests are heart failure, coronary heart disease and the global prevention of heart disease and stroke.

Contenuti

Introduction: Heart Failure as a Public Problem SECTION 1 PATHOPHYSIOLOGY of the MYOCARDIUM: Cellular Physiology of the Myocyte Contraction. Cardiac Interstitium. Biological Determinents of Myocardial Function. Cellular and Molecular Biology of the Myocardium, Growth & Hypertrophy. Molecular Genetics of Cardiomyopathies. ATP Synthesis in the Normal and Failing Heart. Myocardial Mechanics. Remodelling, Hibernation and Stunning. Neurohormonal Receptors in the Failing Heart. SECTION II PATHOPHYSIOLOGY of the CIRCULATION: Humoral Control of the Kidney During Congestive Heart Failure: Role of Cardiac Natriuretic Peptides and Angiotensin II. Pathogenesis of Salt and Water Retention in the Congestive Heart Failure Syndrome. Endothelial Factors. Regional Vascular Control. Sympathetic Nervous System. Vasoactive Hormone Systems. Skeletal Muscle Abnormalities. Involvement of the Lungs. Syndrome of Cardiac Cachexia. SECTION III CLINICAL ASPECTS of HEART FAILURE: History, Definition and Classification of Heart Failures. Epidemiology of Heart Failure in the United States. Epidemiology of Heart Failure in Europe . Syndrome of Chronic Heart Failure: Origin of Symptoms. Valvular Heart Disease. Hypertension and Cardiac Hypertrophy. Diastolic Heart Failure. Heart Failure During Pregnancy. Hyperactive Cardiomyopathy. Dilated Cardiomyopathy. Cardiomyopathies and Specific Heart Muscle Diseases SECTION IV DIAGNOSIS, EVALUATION and PROGNOSIS: Prognostic Factors. Roleof Exercise Testing. Role of Echocardiography in the Diagnosis and Treatment of Cardiomyopathies. Radionuclide Methods. Endomyocardial Biopsy. Magnetic Resonance Imaging, Computed Tomogrpahy and Positron Emission Tomography. SECTION V THERAPY: Acute Ischemic Heart Failure. Chronic Heart Failure: Diagnosis and Management. Pediatric Heart Failure: Pathophysiology, Clinical Presentation, And Treatment. Heart Failure in Elderly Patients: Focus on Diastolic Dysfunction. Large Trials an D Meta-Analysis. Nonpharmacologic Interventions. Diuretic Therapy. Cardiac Glycosides. Vasodilator Therapy. Drugs for Heart Failure that Interfere with the Renin-Angiotensin System. Positive Inotropic Therapy. Beta-Adrenoceptor Antagonists. Calcium Channel Blockers. Management of Arrhythmias in Patients with Heart Failure: Evaluation and Treatment with Drugs and Devices. Anticoagulants and Antiplatelet Agents. Surgery for Chronic Heart Failure. Candidates for Heart Transplantation: Selectionand Management. Managing Heart Failure with Transplantation, Ventricular Assist Devices, And Cardiomyoplasty. Management of Refractory Heart Failure. Future Directions in the Treatment of Heart Failure

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