This publication is the fourth proceedings volume in a series of "Symposia on Tissue Engineering for Therapeutic Use", sponsored by the Japan Society for Promotion of Science (JSPS). The previous three volumes have all been published as part of the "ICS" series. The successful growth of the interdisciplinary field of modern tissue engineering requires a focused integration of biomedical engineering, life science, and clinical medicine. As we enter the new millennium, it is particularly appropriate to discuss the different hurdles tissue engineering has to identify, define and act upon to substantially contribute to clinical medicine. Current trends covered in this volume include: physiological roles of connective tissue growth factor (CTGF), bone tissue engineering on biodegradable scaffolds, strategies for mesenchymal or skeletal tissues, artificial nerve connection, and xenogeneic extracorporeal liver perfusion. Lessons are learnt from regeneration in animals and steps made towards developing clinical application from these.
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Physiological roles of Connective Tissue Growth Factor (CTGF/Hcs24): Promotion of endochondral ossification, angiogenesis and tissue remodeling (M. Takigawa). Bone tissue engineering on biodegradable scaffolds (J.E. Davies, D. Baksh). Synthesis design of functionally graded fluoridated apatite and CO3 apatite (M. Okazaki). Mechanisms of platelet thrombus formation (Z.M. Ruggeri). Tissue interactions and genetic regulations in gut differentiation (S. Yasugi, K. Fukuda). Establishment of cardiomyogenic cell line from marrow stroma (K. Fukuda et al.). Tissue engineering strategies for mesenchymal or kkeletal tissues (A.I. Caplan). Regulatory mechanism of osteoblast differentiation (A. Yamaguchi). Bone regeneration by bone morphogenetic protein (I. Asahina et al.). Brain barrier function: Its analysis and reconstitution (T. Terasak et al.). Cell sheet engineering (M. Yamato et al.). Selection of primary hemopoietic cells using chemical inducers of dimerization (A.C. Blau). Mechanical stress and actin filament dynamics in cultured endothelial cell (M. Sato et al.). Generation of molecular probes for hematopoietic cell purification (S. Takahashi et al.). What do we learn from regeneration in lower animals? (S. Tochinai). Artificial nerve connection - an interface for controlling prosthesis and organ functions (H.A. Richter, U. Schnakenberg, C. Ziegmann). Neural repair of spinal cord injury (S. Kawaguchi). Efficacy of hepatocyte-based bioartificial liver on hepatic failure in pigs and several attempts towards clinical application (H. Fujioka et al.). Xenogeneic extracorporeal liver perfusion as a liver assist device (I. Ikai et al.). Index of authors. Keyword index.
Book by Ikada Yoshito Shimizu Yoshihiko Shimizu Y Ikada Y
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