In developing annual 20 the goal of the editors was to offer a timely critical review of the literature that has appeared in 2001 focusing mainly on novel therapeutic approaches in the areas of drugs and biologics.
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Giuseppe Giaccone is Head of the Department of Medical Oncology at the Free University Medical Center in Amsterdam, The Netherlands. He graduated at the Medical School in Turin, Italy, in 1980, before specializing in internal medicine and medical oncology at the same institution until 1988. From 1988 to 1990, he pursued a 2-year basic science fellowship at the US National Cancer Institute, studying the biology of lung cancer. From 1990, he held a senior position as a medical oncologist at the Free University Medical Center in Amsterdam. He was appointed Professor of Medical Oncology in 2000 and became Head of the Department of Medical Oncology in January 2003. Between 1993 and 2000 he was chairman of the EORTC Lung Cancer Group.
Section 1: Drugs.
Thymidylate Synthase Inhibitors (S. Ackland); New Nucleoside Analogues in Clinical Development (W. Plunkett); Anthracyclines (L. Gianni); Tubulin Targeting Agents (W.N. Hait); Topoismerase I Interactive Agents (C.F. Stewart); Topoisomerase II Inhibitors (K. Hande); Farnesyltransferase Inhibitors (A.A. Adjei); Cyclin-Dependent Kinases as Targets for Cancer Therapy (A.M. Senderowicz); DNA-Binding Agents (Y. Nieto); The Evolving Role of Endocrine Therapy for the Treatment and Prevention of Breast Cancer (W. Gradishar); New Targets for Cancer Chemotherapy (A.J. Murgo)
Section 2: Biological Response Modifiers.
The Graft-versus-Tumor Effect and the Escape of Maliganancy from Immune Regulation (A.J. Barrett); Donor Lymphocyte Infusions for Hematopoitic Malignancy (S. Slavin); Diptheria Toxin Conjugate Therapy of Cancer (A.E. Frankel); Genetically Engineered T Cells as Adoptive Immunotherapy of Cancer (R.P. Junghans); Integrating IL-12 into Therapeutic Cancer Vaccines (T. Grajewski); Immunotherapy for Breast Cancer (K.L. Knutson); Immunotherapy of Melanoma (P.B. Chapman); CEA Loaded Dendritic Cell Vaccines (M.A. Morse).
Section 3: Tumours.
Leukemias and Plasma Cell Myeloma (P. Wiernik); Lymphomas (A. Santoro); Head and Neck Cancer (M. Al-Sarraf); Upper Gastrointestinal Tumors (K. Aiba).
Cancers of the Large Bowel and Hepatobiliary Tract (T.S. d'Entremont); Malignant Neuroendocrine Tumors (E. Tiensuu); Genitourinary Malignancies (M.D. Michaelson); Breast Cancer (G. Bonadonna); Melanoma (A. Schneeberger); Sarcomas (J. Verweij); Brain Tumors (L. Ashby); Biology and Therapy of Malignant Solid Tumors in Childhood (H. van den Berg); Supportive Care (M. Markman); Aids-Associated Malignancies (M.H. Shah).
Section 4: Lung Cancer.
CT Screening for Lung Cancer (C. Henschke); Biology of Lung Cancer (A. Guzdar); Combined Modality of Treatment of Lung Cancer (NSCLC and SCLC) (T. Le Chevalier); Update on the Systemic Treatment of Lung Cancer (G. Giaccone); Novel Therapeutics for Advanced Non-small Cell Lung Cancer (R. Herbst); Novel therapies for the Treatment of Non-small Cell Lung Cancer (D. Johnson).
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