Multiple Aspects of DNA and RNA: from Biophysics to Bioinformatics: Lecture Notes of the Les Houches Summer School 2004 - Brossura

Brossura

ISBN 10: 0444550623 ISBN 13: 9780444550620

Casa editrice: Elsevier Science, 2014

Riassunto

This book is dedicated to the multiple aspects, that is, biological, physical and computational of DNA and RNA molecules. These molecules, central to vital processes, have been experimentally studied by molecular biologists for five decades since the discovery of the structure of DNA by Watson and Crick in 1953. Recent progresses (e.g. use of DNA chips, manipulations at the single molecule level, availability of huge genomic databases . . . have revealed an imperious need for theoretical modelling. Further progresses will clearly not be possible without an integrated understanding of all DNA and RNA aspects and studies. The book is intended to be a desktop reference for advanced graduate students or young researchers willing to acquire a broad interdisciplinary understanding of the multiple aspects of DNA and RNA. It is divided in three main sections: The first section comprises an introduction to biochemistry and biology of nucleic acids. The structure and function of DNA are reviewed in R. Lavery's chapter. The next contribution, by V. Fritsch and E. Westhof, concentrates on the folding properties of RNA molecules. The cellular processes involving these molecules are reviewed by J. Kadonaga, with special emphasis on the regulation of transcription. These chapters does not require any preliminary knowledge in the field (except that of elementary biology and chemistry). The second section covers the biophysics of DNA and RNA, starting with basics in polymer physics in the contribution by R. Khokhlov. A large space is then devoted to the presentation of recent experimental and theoretical progresses in the field of single molecule studies. T. Strick's contribution presents a detailed description of the various micro-manipulation techniques, and reviews recent experiments on the interactions between DNA and proteins (helicases, topoisomerases, . . . The theoretical modeling of single molecules is presented b

Su questo libro

L'autore

Didier Chatenay activities since 1995 is devoted to experimental research at the frontiers between physics and biology. His first contributions were in the field of single molecule experiments and particulary in the micromanipulation of single nucleic acid molecules (DNA, RNA). In particular he evidenced new structural transitions of a single DNA molecule submitted to an external force.

Dettagli dell'edizione

• Editore: Elsevier Science
• Data di pubblicazione: 2014
• Lingua: Inglese
• ISBN 10: 0444550623
• ISBN 13: 9780444550620
• Rilegatura: Copertina flessibile
• Numero di pagine: 378
• Redattore: Chatenay Didier
• Contatto del produttore: non disponibile
• Persona responsabile: Barbara Criscuolo; b.criscuolo@lswr.it; ; Via Spadolini, 7; Milano; 20141; Italia