Structural Bioinformatics - Rilegato

Rilegato

ISBN 10: 0471202002 ISBN 13: 9780471202004

Casa editrice: Wiley-Liss, 2003

Riassunto

From the Foreword...
"[A] must read for all of us committed to understanding the interpla of structure and function...[T]he individual chapters outline the suit of major basic life science questions such as the status of effort to predict protein structure and how proteins carry out cellula functions, and also the applied life science questions such as ho structural bioinformatics can improve health care through acceleratin drug discovery."

This book provides a basic understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics. The reader emerges with the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Moreover, it draws a clear connection between structural studies and the rational design of new therapies

Su questo libro

L'autore

PHILIP E. BOURNE, PhD, is a professor in the Department of Pharmacology at the University of California, San Diego, and Director of Integrated Biosciences at the San Diego Supercomputer Center. He is also President of the International Society for Computational Biology (ISCB). Dr. Bourne is the author of over 100 peer-reviewed scientific papers and three previous books.

HELGE WEISSIG, PhD, is a Project Leader in Bioinformatics at ActivX Biosciences, a proteomics company, and also co-coordinates the Bioinformatics Certificate program for UCSD Extension. After doing his postdoctoral work with Professor Bourne at the San Diego Supercomputer Center, he became the Technical Project Manager for the RCSB Protein Data Bank (PDB) at UCSD.

Dalla seconda/terza di copertina

The emerging discipline of structural bioinformatics comprises the development of computational technologies for methods of storage, retrieval, and analysis of the three-dimensional structure of biological macromolecules. Edited by Philip Bourne and Helge Weissig, this groundbreaking text provides a thorough understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics.

Structural Bioinformatics begins with chapters on the fundamentals of protein structure, DNA/RNA structure, carbohydrates, and techniques including X-ray crystallography, NMR, cryo-electron microscopy, and molecular visualization. The next section addresses data representation and databases, followed by information on structure classification of proteins (SCOP) and class, architecture, topology, and homology (CATH) classification. Later chapters cover structure-function assignment, protein interactions, and proteins as drug targets. Structural Bioinformatics also:

• Covers the theory, biology, resources, and practical applications for computational approaches to biomolecular structural studies
• Provides broad-based, concise coverage with a consistent direction
• Offers detailed coverage for practitioners while remaining accessible to the novice
• Presents computational analysis of growing masses of structural data as the key to advances in pharmacogenomics

The book concludes with several chapters on structure prediction methods, and discussion of the future of high-throughput structure determination in drug design.

Readers will gain the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Molecular biologists, biochemists, biophysicists, and bioinformaticians in basic and clinical research, as well as undergraduate and graduate students in biology, medicine, and computer science, will find Structural Bioinformatics to be an essential addition to their professional and academic libraries.

Dettagli dell?edizione

• Editore: Wiley-Liss
• Data di pubblicazione: 2003
• ISBN 10: 0471202002
• ISBN 13: 9780471202004
• Rilegatura: Copertina rigida
• Lingua: Inglese
• Numero di pagine: 649
• Redattore: Bourne Philip E., Weissig Helge