Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels - Rilegato

 
9780471930136: Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels
Rilegato
ISBN 10: 047193013X ISBN 13: 9780471930136
Casa editrice: John Wiley & Sons Inc, 2009

Sinossi

This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.

Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

Informazioni sull?autore

VALENTIN K. GRIBKOFF, PHD, is the Chief Scientific Officer and Senior Vice President of Discovery Research at Knopp Neurosciences. He is also an Adjunct Associate Professor in the Department of Pharmacology at Yale University School of Medicine. Dr. Gribkoff has published 100 articles and holds twelve patents.

LEONARD K. KACZMAREK, PHD, is a Professor in the Departments of Pharmacology and Molecular and Cellular Physiology at Yale University School of Medicine. Dr. Kaczmarek has edited or authored two books and over 200 articles. He has served on the editorial boards of The Journal of Neuroscience, Journal of Molecular Neuroscience, The Journal of Experimental Biology, and New Biologist.

Dalla quarta di copertina

New promising tools for drug development and discovery researchers

This contributed work features state-of-the-science reviews of the structure, function, and modulation of neuronal voltage-gated ion channels, with an emphasis on their new and emerging applications to drug discovery and development. The reviews, written by leading experts in the field, are either comprehensive reviews of particular voltage-gated ion channel members or in-depth reviews of topics relevant to multiple voltage-gated ion channel subfamilies.

Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels is divided into three logical sections:

  • Section One: Neuronal Voltage-Gated Ion Channel Functions
  • Section Two: Modulatory Mechanisms and Influences on Neuronal Voltage-Gated Ion Channel Function
  • Section Three: Drug Discovery Targets and Technology
Among the key topics addressed are:
  • Biochemical and molecular mechanisms and pathways in neuronal voltage-gated ion channel regulation
  • Physiological bases of targeting ion channels in disease
  • Advances in screening technologies, and methods for regulating neuronal voltage-gated ion channels
  • Custom-developed technologies for ion channel drug discovery
  • Utility of neuronal voltage-gated ion channel targets for the development of new medicines in traditional and emerging therapeutic areas

Collectively, this book's reviews provide students and researchers with many new tools and approaches for their current ion channel and drug discovery research. Moreover, the book points the direction to promising areas of investigation worthy of further study.

Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.

Editore
John Wiley & Sons Inc
Data di pubblicazione
2009
Lingua
Inglese
ISBN 10 
047193013X
ISBN 13 
9780471930136
Rilegatura
Copertina rigida
Numero di pagine
475
Redattore
Gribkoff Valentin K., Kaczmarek Leonard K.
Contatto del produttore
non disponibile
Persona responsabile
non disponibile