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The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world.
The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era.
The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets.
In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches.Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists.
The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.
Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.
Contenuti
List of Contributors. Editorial; R. Pochet. Overview: From Genes to drugs; J. Haiech, M. Hilbert. Part One: Basic Mechanisms of Action of Calcium. Calcium and apoptosis: M. Maki, S. Christakos, F. Barletta, M. Huening, J. Kohut, M. Raval-Pandya. Calcium and cellular aging: A. Verkhratsky, E. Toescu. Calcium and growth factor: A. Villalobo, M.J. Ruano, P.I. Palomo-Jiménez, H. Li, J. Martín-Nieto, J. Heemskerk. Calcium signalling in excitable cells: N. Macrez, J. Mironneau, S.J. Marsh, N. Wanaverbecq, A.A. Selyanko, D. Brown. Calcium signalling in extracellular matrix: A. Koch, J. Engel, P. Maurer, D.T. Wardm D. Riccardi. Calcium signalling in non-excitable cells: A. Guse, G.J. Barritt, K.-H. Braunewell, C. Reissner, E.D. Gundelfinger, L. Combettes, C. Clair, M. Claret, T. Tordjmann. Calcium storage and release: J. Parys, I. Sienaert, S. Vanlingen, G. Callewaert, P. De Smet, L. Missiaen, H. de Smedt, M. Michalak, K. Nakamura, S. Papp, M. Opas, D. Rossi, V. Barone, I. Simeoni, V. Sorrentino, H. Kawamichi, A. Nakamura, M. Kohama. Part Two: Calcium Related Diseases: R. Valenta, A. Twardosz, I. Swoboda, B. Hayek, S. Spitzauer, D. Kraft, H. Pollard, M. Srivastava, P. Eggleton, D. Llewellyn, P. van Zwieten, D. Pietrobon, S. Islam, F. Rodriguez de Fonseca, M. Angel Gorriti, M. Navarro. Calcium and Muscle disease: Y. Ono, S. Hata, H. Sorimachi, K. Suzuki. Cancer: R.L. Gee, L. Subramanian, T.S. Walker, P.R. van Ginekl, A.S. Polans, P. Paterlini-Bréchot, M. Chami, D. Gozuachik, D.J. Weber, R.R. Rustandi, F. Carrier, D.B. Zimmer, K.Y. Chun, D. Sacks, E. Brown, N. Chattopadhyay,M. Bai. Inflammatory diseases: G. Hagens, G. Siegenthaler. Liver diseases: K. Kobayashi, M. Iijima, T. Yasuda, D.S. Sinasac, N. Yamaguchi, L.-C. Tsui, S. Scherer, T. Saheki. Neurodegeneration: M.E. Spira, N. Ziv, R. Oren, A. Dormann, D. Gitler. Neurodegenerative diseases: M. Monteiro, S. Stabler, B. Keller. Part Three: Methodological Chapters: J. Haiech, J.-L. Galzi, M. Hibert, V. Dupriez. Calcium imaging, fluorescence microscopy, confocal microscopy: A. Nadal, B. Soria, A. Pesty, J. Pocock, G. Evans, G. Monteith, V. Dedov, B. Roufogalis. Index.
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Calcium: The molecular basis of calcium action in biology and medicine
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches.Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument. 776 pp. Englisch. Codice articolo 9780792364221
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Taschenbuch. Condizione: Neu. Calcium: The molecular basis of calcium action in biology and medicine | R. Pochet (u. a.) | Taschenbuch | xxxix | Englisch | 2000 | Springer | EAN 9780792364221 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu Print on Demand. Codice articolo 105649753
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Condizione: New. The first section of this text introduces the reader to the role of calcium in cell biology. The second section discusses the role of calcium and its partners in common diseases such as migraine and drug dependence. The final section gives information on new methods and devices for calcium imaging. Editor(s): Pochet, Roland; Donato, Rosario; Haiech, J.; Heizmann, Claus W.; Gerke, Volker. Num Pages: 732 pages, 32 black & white tables. BIC Classification: MFG; MFN. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 240 x 160 x 39. Weight in Grams: 1343. . 2000. Softcover reprint of the original 1st ed. 2000. Paperback. . . . . Codice articolo V9780792364221
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Calcium: The molecular basis of calcium action in biology and medicine
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Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world.The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era.The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets.In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches.Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists.The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 776 pp. Englisch. Codice articolo 9780792364221
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Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches.Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument. Codice articolo 9780792364221
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Condizione: New. The first section of this text introduces the reader to the role of calcium in cell biology. The second section discusses the role of calcium and its partners in common diseases such as migraine and drug dependence. The final section gives information on new methods and devices for calcium imaging. Editor(s): Pochet, Roland; Donato, Rosario; Haiech, J.; Heizmann, Claus W.; Gerke, Volker. Num Pages: 732 pages, 32 black & white tables. BIC Classification: MFG; MFN. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 240 x 160 x 39. Weight in Grams: 1343. . 2000. Softcover reprint of the original 1st ed. 2000. Paperback. . . . . Books ship from the US and Ireland. Codice articolo V9780792364221
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