Tumor Angiogenesis and Microcirculation - Rilegato

Voest, Emile E.; D'Amore, Patricia A.

Rilegato

ISBN 10: 0824702646 ISBN 13: 9780824702649

Casa editrice: CRC Press, 2001

Riassunto

Compiling the latest developments in anticancer therapies based on the connection between tumor and capillary growth, Tumor Angiogenesis and Microcirculation presents a comprehensive overview of diverse aspects of angiogenesis-related cancer research.
Highlights the role angiogenesis and its inhibitors play in the growth, metastasis, and dormancy of tumors!
Facilitating the progress of clinical practice with insights from methodological and scientific results, Tumor Angiogenesis and Microcirculation

summarizes biological principles of angiogenesis and microcirculation, from endothelial cells and pericytes, and extracellular matrix regulation to matrix metalloproteinases (MMPs) and plasmin and plasmin inhibitors

examines proangiogenic factors such as vascular endothelial (VEGF) and basic fibroblast (bFGF) growth factors, tie receptors, and cytokines

outlines methods for discovering angiogenesis stimulators and inhibitor peptides, particularly the clinical development of thrombospondin, angiostatin, endostatin, and MMP inhibitors

reveals the link between oncogenes and neoplastic angiogenesis and its regulation by the organ microenvironment

investigates tumor vascularity in relation to tumor growth and the spread of cancer

details promising future applications, including perspectives in vascular cancer therapy

and more!
Combining the resources of 60 recognized experts and nearly 3000 pertinent literature references, drawings, photographs, and x-rays, Tumor Angiogenesis and Microcirculation profits oncologists, pathologists, hematologists, and radiation and hemato-oncologists; surgeons and internists; cardiologists; immunologists; cell, molecular, and developmental biologists; rheumatologists; ophthalmologists; dermatologists; and medical school students in these disciplines.

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Contenuti

Biological Principles of Angiogenesis

Endothelial Cells and Pericytes in Tumor Vasculature
Diane C. Darland and Patricia A. D'Amore
The Extracellular Matrix and the Regulation of Angiogenesis
Joseph A. Madri
Matrix Metalloproteinases (Matrixins) and Their Inhibitors (TIMPS) in Angiogenesis
Teresa A. Bennett and William G. Stetler-Stevenson
Regulation of Cell Migration in the Process of Angiogenesis
Bela Anand-Apte and Bruce R. Zetter
Plasmin, Plasmin Inhibitors, and Angiogenesis
Martijn F. B. G. Gebbink

Assays to Study Angiogenesis

Assays to Study Angiogenesis
Robert Auerbach and Wanda Auerbach
Screening for Angiogenesis Inhibitors with the Chick Chorioallantoic Membrane and the Mouse Corneal Micropocket Assays
Robert J. D'Amato
Capillary Morphogenesis In Vitro: Cytokine Interactions and Balanced Proteolysis
Roberto Montesano and Michael S. Pepper
Skin Fold Chamber Models
Michael Leunig and Konrad Messmer
Protease Assays and Their Use in the Discovery of Novel Regulators of Angiogenesis
Li Yan, Inmin Wu, and Marsha A. Moses

Angiogenic Factors

Vascular Endothelial Growth Factor/Vascular Permeability Factor: Multiple Biological Activities for Promoting Angiogenesis
Donald R. Senger
Tie Receptors, Ang Ligands
Yuji Gunji, Arja Kaipainen, Kristiina Iljin, Eola Kukk-Valdre, Berndt Enholm, and Kari Alitalo
Vascular Endothelial Growth Factor Receptors
Arja Kaipainen, Eija Korpelainen, and Kari Alitalo
Regulation of Vascular Endothelial Growth Factor (VEGF) Expression
Ilan Stein and Eli Keshet
Fibroblast Growth Factors
David A. Moscatelli and Daniel B. Rifkin
Role of Proangiogenic Cytokines and Inhibitors of Neovascularization in Tumor Angiogenesis
Peter J. Polverini and Robert M. Strieter

Regulation of Angiogenesis

The Link Between Oncogenes, Signal Transduction Therapy, and Tumor Angiogenesis
Robert S. Kerbel, Alicia Viloria-Petit, Futoshi Okada, and Janusz Rak
Genetic Control of Angiogenesis by Tumor Suppressor Genes
Maartje Los and Emile E. Voest
Regulation of Neoplastic Angiogenesis by the Organ Microenvironment
Rakesh Kumar and Isaiah J. Fidler
Role of Macrophages in Tumor Angiogenesis
Peter J. Polverini
Phenotypic Analysis of Endothelium from the Tumor Vasculature
Gerard Groenewegen and Arjan W. Griffioen

Angiogenesis Inhibitors: Preclinical and Clinical Drugs

Drug Delivery and Angiogenesis Inhibition in the Treatment of Brain Tumors
Laurence D. Rhines, Matthew G. Ewend, and Henry Brem
Matrix-Associated Endogenous Inhibitors of Angiogenesis
Raghu Kalluri and Vikas P. Sukhatme
vß? and Its Antagonists in the Control of Angiogenesis
Brian P. Eliceiri and David A. Cheresh
The Role of Vascular Endothelial Growth Factor in Angiogenesis
Napoleone Ferrara
TNP-470: Preclinical and Clinical Development
Deborah M. Milkowski and Rachelle A. Weiss
Matrix Metalloproteinase Inhibitors
Peter D. Brown
Tumoral Vascularity: What Does It Tell Us About the Growth and Spread of Cancer?
Noel Weidner
The Prognostic and Diagnostic Value of Circulating Angiogenic Factors in Cancer Patients
Olaf A. J. Kerckhaert and Emile E. Voest

Future Perspectives

Perspectives in Vascular Cancer Therapy: An Introduction
Geert H. Blijham
The Combination of Antiangiogenic Therapy with Cytotoxic Therapy: A Systems Approach
Beverly A. Teicher
Targeting the Vasculature of Solid Tumors
Philip E. Thorpe and Sophia Ran
Combining Antivascular Approaches with Radiotherapy: A Perspective
Juliana Denekamp
Antiangiogenic Gene Therapy
Jaap C. Reijneveld and Emile E. Voest

Dettagli dell'edizione

• Editore: CRC Press
• Data di pubblicazione: 2001
• Lingua: Inglese
• ISBN 10: 0824702646
• ISBN 13: 9780824702649
• Rilegatura: Copertina rigida
• Numero edizione: 1
• Numero di pagine: 648
• Contatto del produttore: non disponibile
• Persona responsabile: non disponibile