Drug Permeation Enhancement: Theory and Applications - Rilegato

Rilegato

ISBN 10: 0824790154 ISBN 13: 9780824790158

Casa editrice: CRC Press, 1993

Riassunto

Providing a comprehensive review of drug permeation enhancement, this reference covers the fundamental aspects of physical and chemical enhancement for the transport of both peptides and nonpeptides through the skin, mucosae, and cornea.;Expanding the frontiers of drug delivery research, drug permeation enhancement details the barrier properties of skin; examines skin penetration enhancers; investigates the transdermal delivery of proteins and peptides by iontophoresis; describes electrically mediated transdermal drug delivery; analyzes obstacles to the transmucosal delivery of peptides and proteins; and discusses ocular peptide absorption mechanisms.;Written by 35 internation authorities working in academia, government, and industry, Drug Permeation Enhancement is for pharmaceutical scientists, research dermatologists, biotechnologists, toxicologists, and graduate students in these disciplines.

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Contenuti

Part 1 General introduction to drug permeation enhancement: understanding permeation enhancement technologies, Dean S. Hsieh; skin penetration enhancers - scientific perspectives, Vinod P. Shah; basic mechanisms in transepithelium transport enhancement, Wei-Chiang Shen and Yi-Jing Lin. Part 2 Drug permeation enhancement via the skin-chemical means: skin permeation enhancement reversibility, Margo B. Haberkamp; visualization of drug transport across human skin and the influence of penetration enhancers, H.E. Junginger et al; compatibility and synergy of permeation enhancers with solvents, excipients, and drugs, Shirley M. Ng; a general method for assessing skin permeation enhancement mechanisms and optimization, Charan R. Behl et al; permeation enhancement with ethanol - mechanism of action through skin, S. Yum et al; Liposomes as penetration promoters and localizers of topically applied drugs, Michael Mezei; barrier properties of skin-skin development and permeation, Tamie Kurihara-Bergstrom and William Good. Part 3 Drug permeation enhancement via the skin-physical means: Iontophoresis-fundamentals, Ooi Wong; transdermal delivery of proteins and peptides by Iontophoresis-development, challenges, and opportunities, Jue-Chen Liu and Ying Sun; In Vivo experience with electrically mediated transdermal drug delivery, B. Robert Meyer; In Vivo and In Vitro characteristics of electro-transermal drug delivery, Mary Martin and John Devane; transdermal drug delivery by phonophoresis-basics, mechanism, and techniques of application, Ying Sun and Jue-Chen Liu. Part 4 Drug permeation enhancement via the nasal route: permeability and metabolism as barriers to transmucosal delivery of peptides and proteins, Bruce J. Aungst; toxicological evaluation of intranasal peptide and protein drugs, Michael A. Dorato. Part 5 Drug permeation enhancement via the ocular route: permeation enhancement for ocular route of polypeptide administration, George C.Y. Chiou and Yu-Qun Zheng; mechanisms of ocular peptide absorption and its enhancement, Yongyut Rojanasakul.

Product Description

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Dettagli dell?edizione

• Editore: CRC Press
• Data di pubblicazione: 1993
• Lingua: Inglese
• ISBN 10: 0824790154
• ISBN 13: 9780824790158
• Rilegatura: Copertina rigida
• Numero edizione: 1
• Numero di pagine: 448
• Redattore: Hsieh Dean S.
• Contatto del produttore: non disponibile
• Persona responsabile: non disponibile