Library Design, Search Methods, and Applications of Fragment-Based Drug Design: 1076 - Rilegato

Rilegato

ISBN 10: 0841224927 ISBN 13: 9780841224926

Casa editrice: OUP USA, 2012

Riassunto

Fragment based ligand design is a promising technique for identifying novel lead compounds for drug discovery. Fragment based discovery involves identifying small low molecular weight compounds with low affinity to the target to use as the foundation for growing and linking to create high affinity lead compounds with high selectivity. Fragment based discovery has facilitated the incorporation of greater chemical diversity in libraries for more efficient novel lead identification This book discusses computational methods for fragment library design, computational docking ranking and screening of fragments and computational methods for linking and growing fragments to yield lead compounds.

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Informazioni sull'autore

Dr. Rachelle J. Bienstock, received her undergraduate degree in Chemical Engineering from The Cooper Union in New York City and her Ph.D. in Chemistry from The University of Michigan in Ann Arbor, Michigan. Following postdoctoral studies at the University of Texas Southwestern Medical Center (Dallas), involving NMR and molecular modeling of constrained peptide analogs and peptidomimetics, she joined The National Institute of Environmental Health Sciences, (NIEHS), Research Triangle Park, NC, as a molecular modeler and computational chemist. Her main research interests are protein structure and protein complex prediction methodologies, computational and structure based ligand design methods and protein-protein and protein-ligand docking studies.

Dettagli dell'edizione

• Editore: OUP USA
• Data di pubblicazione: 2012
• Lingua: Inglese
• ISBN 10: 0841224927
• ISBN 13: 9780841224926
• Rilegatura: Copertina rigida
• Numero di pagine: 216
• Redattore: Bienstock Rachelle
• Contatto del produttore: non disponibile
• Persona responsabile: Messaggerie Libri ; ufficio.anagrafiche@meli.it; ; Via Verdi, 8; Assago Milano; Italia