Endothelin Receptors: From the Gene to the Human: 21 - Rilegato

Libro 16 di 16: Handbooks in Pharmacology and Toxicology

Ruffolo Jr., Robert R.

 
9780849359385: Endothelin Receptors: From the Gene to the Human: 21
Rilegato
ISBN 10: 0849359384 ISBN 13: 9780849359385
Casa editrice: CRC Press, 1995

Sinossi

Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans. This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.

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Informazioni sull?autore

Robert R. Ruffolo Jr.

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Editore
CRC Press
Data di pubblicazione
1995
Lingua
Inglese
ISBN 10 
0849359384
ISBN 13 
9780849359385
Rilegatura
Copertina rigida
Numero edizione
1
Numero di pagine
304
Contatto del produttore
non disponibile
Persona responsabile
non disponibile