Articoli correlati a IL-4
Sinossi
The Structure and Function of Interleukin-4 provides a detailed summary of the pleiotrophic effects of IL-4. In Section I, the structure of the IL-4 gene, IL-4R gene, and IL-4 protein are described. In Section II, in vitro effects of IL-4 are reviewed and focus is on particular cell lineage, as well as the role of IL-4 in hemopoiesis. Section III features chapters that discuss the effects of IL-4 in vivo, highlighting the dramatic ability of IL-4 to induce the switch of B cells to produce IgE. The Structure and Function of Interleukin-4 is an important book for immunologists, cell biologists, and pharmacologists who need a succinct description of the role of IL-4 in the development of different cell types and in cell-cell communication in the immune system.
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Contenuti
Preface. STRUCTURE OF IL-4 AND ITS RECEPTOR. IL-4 Gene: Regulation of Expression (N. Arai and K.-I. Arai). Physicochemical and Structural Characteristics of IL-4 (P.P. Trotta). IL-4 Receptor (N. Harada, M. Howard, and A. Miyajima). IN VITRO EFFECTS OF IL-4. The Role of IL-4 in the Regulation of B Cell Development, Growth and Differentiation (W.E. Paul). Mechanisms of Murine Isotype Regulation by IL-4 (C.L. Schultz and R.L. Coffman). Regulation of IgE Synthesis (J.-F. Gauchat, G. Aversa, H. Gascan, R. de Waal Malefyt, and J.E. de Vries). Role of IL-4 in Thymic Development (A. Zlotnik). IL-4 Production by Murine T Cells (T.R. Mosmann). Human T. Cells and IL-4 (H. Yssel and H. Spits). IL-4 and Hematopoiesis (D.M. Rennick, J.G. Moore, and L.-A. Thompson-Snipes). Immunomodulating Effects of IL-4 on Human Natural Killer Cells (J.H. Phillips, A. Nagler, H. Spits, and L.L. Lanier). Regulation of Human Monocyte Phenotype and Function by IL-4 (C.G. Figdor and A.A. te Velde). IN VIVO EFFECTS OF IL-4. Immunological Effects of IL-4 In Vivo: Studies with Transgeneic Mice (R.I. Tepper, H.J. Burstein, P. Leder, and A.K. Abbas). Cytokine Regulation of Murine Immunoglobulin Isotype Expression In Vivo (F.D. Finkelman, J.F. Urban, Jr., W.E. Paul, and I.M. Katona). Role of IL-4 in the Antitumor Response (M.T. Lotze). Index.
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