An All-Inclusive Review of the Achievements and Trends in the Fast-Growing Protein Engineering Field
From humble beginnings like making fire for mere survival, engineering now steadfastly penetrates all aspects of our lives and even life itself at the molecular level. Protein engineering is a molecular biological discipline focused on designing and constructing novel proteins with desired properties. The currently limited understanding of the relationship between protein structure and function greatly hinders rational protein design. However, despite great challenges, protein engineering has become a major molecular discipline with a large array of successful applications to many complex medicinal problems.
Medicinal Protein Engineering sheds light on this largely unchartered field, covering major strategies for engineering of proteins with predetermined biological properties. It discusses computational approaches to protein design and experimental approaches to protein construction. This volume also explores the tight connection between protein and genetic engineering. It moves researchers beyond experimental protein construction and theoretical protein design to the medicinal applications of engineered proteins.
Examines Medicinal Applications of Protein Engineering for the Diagnosis, Treatment, and Prevention of Diseases
Focusing on the application of protein engineering to medicine, this seminal work outlines the appropriate techniques for studying protein properties and building mathematical engineering models of novel vaccines, diagnostic reagents, and therapeutic treatments. As a truly comprehensive assessment of the medical protein engineering research available and its future implications for disease control and prevention, this is an indispensable reference for biological researchers in this groundbreaking field.
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Computational Approaches
Web Resources for Protein Analysis, S. A. Cammer and M. Czar
Artificial Neural Networks for Therapeutic Protein Engineering, J. Lara
Phylogenetics and Medicinal Protein Engineering, M.A. Purdy
Clustering and Classification Approaches to Identifying Protein Properties, L.M. Ganova-Raeva and Z.E. Dimitrova
Analysis of Coordinated Substitutions in Proteins, D. Campo
Protein Engineering Targets: Vaccine Tuning the Immune Response to Our Advantage: Design of Vaccines with Tailored Functions, M.F. Bachmann and T.A. Röhn
Modification of HIV-1 Envelope Glycoprotein to Enhance Immunogenicity, M. Aidoo, S. Butera, and D. Ellenberger
Engineering Better Influenza Vaccines: Traditional and New Approaches, P.M. Pushko, R.A. Bright, T.M. Tumpey, and G.E. Smith
Construction of Novel Vaccines on the Basis of Virus-Like Particles: Hepatitis B Virus Proteins as Vaccine Carriers, P. Pumpens, R.G. Ulrich, K. Sasnauskas, A. Kazaks, V. Ose, and E. Grens
Polyomavirus-Derived Virus-Like Particles, R.G. Ulrich, A. Gedvilaite, T. Voronkova, A. Kazaks, R. Johne, and K. Sasnauskas
Papillomavirus-Derived Virus-Like Particles, A. Kazaks and T. Voronkova
Recombinant Vaccines Against Hepatitis Viruses, J. Yokosawa, N.O. Perez, and L.M.G. Rossi
Protein Engineering Targets: Diagnostics and Therapy Designer Diagnostic Reagents and Allergens, A. Obriadina
Peptide-Based Diagnostic Assays, M.J. Gómara and I. Haro
Recombinant Antibodies, A. Likhacheva and T. Ulanova
Protein Engineering for HIV Therapeutics, J.M. Smith, D. Ellenberger, and S. Butera
Recombinant Enzymes with New and Improved Properties, L.M. Ganova-Raeva
Special Expression Systems
Production of Pharmaceutical Compounds in Plants, M.A. Gómez Lim
Plant Virus Biotechnology Platforms for Expression of Medicinal Proteins, A. Zeltins
Alphaviruses: Multiplicity of Vectors and Their Promising Application as Vaccines and Cancer Therapy Agents, A. Zajakina, B. Niedre-Otomere, J. Alekseeva, and T. Kozlovska
Index
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