Protein Structure Prediction: Methods and Protocols: v. 143 - Rilegato

Rilegato

ISBN 10: 0896036375 ISBN 13: 9780896036376

Casa editrice: Humana Pr Inc, 2000

Riassunto

Protein Structure Prediction is aimed at the novice, as well as experienced researchers in this field who all need detailed information that combines theoretical and practical aspects. Its major intent is to include information relevant to the daily work of a research scientist, but may not always be obvious in the original scientific literature. Covers many aspects, from sequence analysis, which is often the starting point for algorithms, through secondary and tertiary methods, to the prediction of docked complexes, which are essential to fully understand biological function. Also covers the development of suitable folding potentials essential for many of the methods presented in the volume. Expert knowledge of protein structure prediction from the contributors is applied to many disciplines, such as the identification of domains and motifs; the comparative modeling of proteins; and ab initio approaches to protein loop, side chain, and protein prediction. This is an essential resource to both the expert and non-expert in the field, as the need for accurate and useful predicted structures continues to increase due to advances in technology and the understanding of the principles of protein structure folding.

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The deeper understanding of protein structure now emerging from cutting-edge research is not only illuminating evolutionary and biochemical mechanisms, but also promises enormous ramifications for molecular medicine, as well as for biotechnology, biophysics, biology, genetics, and other molecular sciences. In Protein Structure Prediction: Methods and Protocols, world-class investigators detail their most successful methods-and the theory behind them-for delineating the shape, form, and function of proteins. The protocols range from basic to advanced and include sequence alignment, the prediction of transmembrane protein structure, and the development of suitable folding potentials. There are also techniques for receptor site prediction, the identification of motifs and domains, the comparative modeling of proteins, the docking of peptides and ligands, and ab initio approaches to protein loop and side-chain prediction. To ensure robust and successful experimental results, each protocol contains step-by-step instructions, as well as tips on pitfalls to avoid and how procedures may be optimized for different systems.
Comprehensive, accessible, and highly practical, Protein Structure Prediction: Methods and Protocols offers protein researchers, structural biologists, and other investigators a critical synthesis of the latest research results, as well as the vital guidance needed to understand the structure and interaction of proteins and peptides.

Dettagli dell'edizione

• Editore: Humana Pr Inc
• Data di pubblicazione: 2000
• Lingua: Inglese
• ISBN 10: 0896036375
• ISBN 13: 9780896036376
• Rilegatura: Copertina rigida
• Numero edizione: 1
• Numero di pagine: 422
• Redattore: Webster David M.
• Contatto del produttore: non disponibile
• Persona responsabile: non disponibile