Probabilistic Boolean Networks: The Modeling and Control of Gene Regulatory Networks

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9780898716924: Probabilistic Boolean Networks: The Modeling and Control of Gene Regulatory Networks

The first comprehensive treatment of probabilistic Boolean networks (an important model class for studying genetic regulatory networks), this book covers basic model properties, including the relationships between network structure and dynamics, steady-state analysis, and relationships to other model classes. As the PBN model can serve as a mathematical framework for studying the basic issues of systems-based genomics, the book builds a rigorous mathematical foundation for exploring these issues, which include long-run dynamical properties and how these correspond to therapeutic goals; the effect of complexity on model inference and the resulting consequences of model uncertainty; altering network dynamics via structural intervention, such as perturbing gene logic; optimal control of regulatory networks over time; limitations imposed on the ability to achieve optimal control owing to model complexity; and the effects of asynchronicity. The authors unify different strands of current research and address emerging issues such as constrained control, greedy control, and asynchronicity.

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Descrizione del libro:

This book is the first comprehensive treatment of probabilistic Boolean networks, an important model class for studying genetic regulatory networks. The PBN model is well-suited to serve as a mathematical framework to study basic issues of systems-based genomics and this book builds a rigorous mathematical foundation for exploring these issues.

L'autore:

Ilya Shmulevich is a Professor at the Institute for Systems Biology, Seattle, WA. Dr Shmulevich received his Ph.D. degree in Electrical and Computer Engineering from Purdue University, West Lafayette, IN, USA, in 1997. He has since worked at the University of Nijmegen, the University of Amsterdam, Tampere University of Technology, the University of Texas and Rice University.

Edward R. Dougherty is a Professor and Director of the Genomic Signal Processing Laboratory at Texas A & M University, College Station, TX. He is also Co-Director of the Computational Biology Division of the Translational Genomics Research Institute, Phoenix, AZ.

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Ilya Shmulevich, Edward R. Dougherty
Editore: SIAM-Society for Industrial and Applied Mathematics (2009)
ISBN 10: 0898716926 ISBN 13: 9780898716924
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Descrizione libro SIAM-Society for Industrial and Applied Mathematics, 2009. Paperback. Condizione libro: New. Codice libro della libreria DADAX0898716926

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Shmulevich, Ilya; Dougherty, Edward R.
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Descrizione libro SIAM-Society for Industrial and Applied Mathematics, 2009. Paperback. Condizione libro: New. book. Codice libro della libreria 0898716926

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Shmulevich, Ilya; Dougherty, Edward R.
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Descrizione libro Condizione libro: New. Depending on your location, this item may ship from the US or UK. Codice libro della libreria 97808987169240000000

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Ilya Shmulevich, Edward R. Dougherty
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Descrizione libro Society for Industrial Applied Mathematics,U.S., United States, 2010. Paperback. Condizione libro: New. New.. 254 x 176 mm. Language: English . Brand New Book. This is the first comprehensive treatment of probabilistic Boolean networks (PBNs), an important model class for studying genetic regulatory networks. This book covers basic model properties, including the relationships between network structure and dynamics, steady-state analysis, and relationships to other model classes. It also discusses the inference of model parameters from experimental data and control strategies for driving network behavior towards desirable states. The PBN model is well suited to serve as a mathematical framework to study basic issues dealing with systems-based genomics, specifically, the relevant aspects of stochastic, nonlinear dynamical systems.The book builds a rigorous mathematical foundation for exploring these issues, which include long-run dynamical properties and how these correspond to therapeutic goals; the effect of complexity on model inference and the resulting consequences of model uncertainty; altering network dynamics via structural intervention, such as perturbing gene logic; optimal control of regulatory networks over time; limitations imposed on the ability to achieve optimal control owing to model complexity; and the effects of asynchronicity. The authors attempt to unify different strands of current research and address emerging issues such as constrained control, greedy control, and asynchronicity. Codice libro della libreria AAN9780898716924

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Ilya Shmulevich, Edward R. Dougherty
Editore: Society for Industrial Applied Mathematics,U.S., United States (2010)
ISBN 10: 0898716926 ISBN 13: 9780898716924
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Descrizione libro Society for Industrial Applied Mathematics,U.S., United States, 2010. Paperback. Condizione libro: New. New.. 254 x 176 mm. Language: English . Brand New Book. This is the first comprehensive treatment of probabilistic Boolean networks (PBNs), an important model class for studying genetic regulatory networks. This book covers basic model properties, including the relationships between network structure and dynamics, steady-state analysis, and relationships to other model classes. It also discusses the inference of model parameters from experimental data and control strategies for driving network behavior towards desirable states. The PBN model is well suited to serve as a mathematical framework to study basic issues dealing with systems-based genomics, specifically, the relevant aspects of stochastic, nonlinear dynamical systems.The book builds a rigorous mathematical foundation for exploring these issues, which include long-run dynamical properties and how these correspond to therapeutic goals; the effect of complexity on model inference and the resulting consequences of model uncertainty; altering network dynamics via structural intervention, such as perturbing gene logic; optimal control of regulatory networks over time; limitations imposed on the ability to achieve optimal control owing to model complexity; and the effects of asynchronicity. The authors attempt to unify different strands of current research and address emerging issues such as constrained control, greedy control, and asynchronicity. Codice libro della libreria AAN9780898716924

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ILYA SHMULEVICH , EDWARD R. DOUGHERTY
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Descrizione libro 2010. Paperback. Condizione libro: NEW. 9780898716924 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. Codice libro della libreria HTANDREE0484215

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Descrizione libro Society for Industrial and Applied Mathematics, 2010. PAP. Condizione libro: New. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Codice libro della libreria CE-9780898716924

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Descrizione libro Society for Industrial & Applied Mathematics,U.S. Paperback. Condizione libro: new. BRAND NEW, Probabilistic Boolean Networks: The Modeling and Control of Gene Regulatory Networks, Ilya Shmulevich, Edward R. Dougherty, The first comprehensive treatment of probabilistic Boolean networks (an important model class for studying genetic regulatory networks), this book covers basic model properties, including the relationships between network structure and dynamics, steady-state analysis, and relationships to other model classes. As the PBN model can serve as a mathematical framework for studying the basic issues of systems-based genomics, the book builds a rigorous mathematical foundation for exploring these issues, which include long-run dynamical properties and how these correspond to therapeutic goals; the effect of complexity on model inference and the resulting consequences of model uncertainty; altering network dynamics via structural intervention, such as perturbing gene logic; optimal control of regulatory networks over time; limitations imposed on the ability to achieve optimal control owing to model complexity; and the effects of asynchronicity. The authors unify different strands of current research and address emerging issues such as constrained control, greedy control, and asynchronicity. Codice libro della libreria B9780898716924

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Shmulevich, Ilya, Dougherty, Edward R.
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Descrizione libro SIAM-Society for Industrial an, 2009. Paperback. Condizione libro: New. Codice libro della libreria P110898716926

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Descrizione libro Society for Industrial & Applied, 2010. Paperback. Condizione libro: Brand New. 267 pages. 9.75x7.00x0.75 inches. In Stock. Codice libro della libreria __0898716926

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