SCN2A-Related Disorders - Brossura

Brossura

ISBN 10: 1009530372 ISBN 13: 9781009530378

Casa editrice: Cambridge University Press, 2025

Riassunto

SCN2A encodes a voltage-gated sodium channel (designated NaV1.2) vital for generating neuronal action potentials. Pathogenic SCN2A variants are associated with a diverse array of neurodevelopmental disorders featuring neonatal or infantile onset epilepsy, developmental delay, autism, intellectual disability and movement disorders. SCN2A is a high confidence risk gene for autism spectrum disorder and a commonly discovered cause of neonatal onset epilepsy. This remarkable clinical heterogeneity is mirrored by extensive allelic heterogeneity and complex genotype-phenotype relationships partially explained by divergent functional consequences of pathogenic variants. Emerging therapeutic strategies targeted to specific patterns of NaV1.2 dysfunction offer hope to improving the lives of individuals affected by SCN2A-related disorders. This Element provides a review of the clinical features, genetic basis, pathophysiology, pharmacology and treatment of these genetic conditions authored by leading experts in the field and accompanied by perspectives shared by affected families. This title is also available as Open Access on Cambridge Core.

Dettagli dell'edizione

• Editore: Cambridge University Press
• Data di pubblicazione: 2025
• Lingua: Inglese
• ISBN 10: 1009530372
• ISBN 13: 9781009530378
• Rilegatura: Copertina flessibile
• Numero di pagine: 96
• Redattore: George Jr. Alfred L.
• Contatto del produttore: Cambridge University Press; https://www.cambridge.org/; ; Via Honduras,15; Pomezia; Italia; 71; Italia