Genes, Development, and Cancer: The Life and Work of Edward B. Lewis - Rilegato

Lewis, Edward B.; Lipshitz, Howard D.

Rilegato

ISBN 10: 140207591X ISBN 13: 9781402075919

Casa editrice: Kluwer Academic Pub, 2004

Riassunto

- For the first time, Nobel Prize winner, Edward B. Lewis' research papers are published within one volume

- Papers are organized into sections that reflect the focus of the research

- Commentaries by Howard Lipshitz highlight key methods and results by explaining the science so it is accessible to upper-level undergraduates, graduate students, and professional researchers

Su questo libro

Contenuti

Background -Invention of the cis-trans test for position effects -Position pseudoalleles -The bithorax pseudoalleles and the concept of developmental control -Gene evolution by tandem duplication -From cisvection to transvection- Extending the bithorax pseudoallelic series -Genetic versus functional models -From genes to gene complexes -Developmental genetics -Gain-of-function and loss-of-function alleles, and the operon model -Genetic mosaics: spatial and temporal aspects of bithorax function -The 1978 paper: a paradigm for the genetic control of development -Trans-acting regulators: positive and negative control of the homeotic complexes -Cis-regulation within the BX-C: the rules of engagement -Positional cloning of the BX-C -Completing the bithorax mutant series -The molecular basis of developmental control -Bithorax and the evolution of sexually dimorphic traits -DNA sequence motifs in the cis-regulatory regions of the BX-C -Evolution of the HOX complexes -Genetic and somatic effects of ionizing radiation -The political and social context -Leukemia and ionizing radiation -Political fallout -Thyroid radiation doses from weapons fallout -Best estimates of risk: leukemia in populations exposed to low doses of radiation -Estimates of lung cancer risk: the Batelle beagles

Dettagli dell'edizione

• Editore: Kluwer Academic Pub
• Data di pubblicazione: 2004
• Lingua: Inglese
• ISBN 10: 140207591X
• ISBN 13: 9781402075919
• Rilegatura: Copertina rigida
• Numero di pagine: 572
• Contatto del produttore: non disponibile
• Persona responsabile: CMN Printpool Inh. Mathis Neumann; https://www.also.com/ec/cms5/en_6000/6000/index.jsp; ; Friedrich-Karl-Str. 9; Hamburg; Germania